| Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules HO Sintim, JAI Smith, J Wang, S Nakayama, L Yan Future medicinal chemistry 2 (6), 1005-1035, 2010 | 185 | 2010 |
| AI-2 analogs and antibiotics: a synergistic approach to reduce bacterial biofilms V Roy, MT Meyer, JAI Smith, S Gamby, HO Sintim, R Ghodssi, WE Bentley Applied microbiology and biotechnology 97, 2627-2638, 2013 | 127 | 2013 |
| Synthetic analogs tailor native AI-2 signaling across bacterial species V Roy, JAI Smith, J Wang, JE Stewart, WE Bentley, HO Sintim Journal of the American Chemical Society 132 (32), 11141-11150, 2010 | 92 | 2010 |
| Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogues S Gamby, V Roy, M Guo, JAI Smith, J Wang, JE Stewart, X Wang, ... ACS chemical biology 7 (6), 1023-1030, 2012 | 59 | 2012 |
| Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules K Kamaraju, J Smith, J Wang, V Roy, HO Sintim, WE Bentley, S Sukharev Biochemistry 50 (32), 6983-6993, 2011 | 55 | 2011 |
| Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous JAI Smith, J Wang, SM Nguyen-Mau, V Lee, HO Sintim Chemical communications, 7033-7035, 2009 | 51 | 2009 |
| Tyrosine kinase inhibition reverses TDP‐43 effects on synaptic protein expression, astrocytic function and amino acid dis‐homeostasis L Heyburn, ML Hebron, J Smith, C Winston, J Bechara, Z Li, I Lonskaya, ... Journal of Neurochemistry 139 (4), 610-623, 2016 | 39 | 2016 |
| Remote C H Functionalization: Using the N O Moiety as an Atom‐Economical Tether to Obtain 1, 5‐and the Rare 1, 7‐C H Insertions J Wang, B Stefane, D Jaber, JAI Smith, C Vickery, M Diop, HO Sintim Angewandte Chemie International Edition 49 (23), 3964-3968, 2010 | 35 | 2010 |
| Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogues reveal distinct mechanisms for ligand recognition JH Ha, Y Eo, A Grishaev, M Guo, JAI Smith, HO Sintim, EH Kim, ... Journal of the American Chemical Society 135 (41), 15526-15535, 2013 | 30 | 2013 |
| A pro-drug approach for selective modulation of AI-2-mediated bacterial cell-to-cell communication M Guo, S Gamby, S Nakayama, J Smith, HO Sintim Sensors 12 (3), 3762-3772, 2012 | 27 | 2012 |
| Development of a novel near-infrared fluorescent theranostic combretastain A-4 analogue, YK-5-252, to target triple negative breast cancer Y Kong, J Smith, K Li, J Cui, J Han, S Hou, ML Brown Bioorganic & Medicinal Chemistry 25 (7), 2226-2233, 2017 | 24 | 2017 |
| Phosphorylated and Branched Dihydroxy-Pentane-Dione (DPD) analogs as quorum sensing inhibitors in bacteria HO Sintim, WE Bentley, V Roy, J Smith, R Ghodssi, MT Meyer US Patent 8,952,192, 2015 | 6 | 2015 |
| Acyclic amidines in the Strecker-like Groebke-Blackburn-Bienayme’(GBB) reaction J Smith, M Osunsanya, I Nwadike, B Tankeu Tetrahedron Letters 100, 153876, 2022 | 4 | 2022 |
| Striving Towards Improving Underrepresented Minority Success in Organic Chemistry: Self-Efficacy and Deep-Learning Strategies J Smith, M Russell Understanding Interventions, 2020 | 2 | 2020 |
| The synthesis of a diverse library of AI-2 analogs to investigate bacterial quorum sensing JA Smith | 1 | 2011 |
| Small molecule, nanoparticle and liposomal strategies for LAT1-mediated chemotherapy delivery JL Bullock, DD Gillette, JA Smith Results in Chemistry 6, 101056, 2023 | | 2023 |
| Small molecule inhibitors of XBP1 splicing S Dakshanamurthy, ML Brown, R Clarke, AN Shajahan-Haq, J Smith US Patent 10,806,725, 2020 | | 2020 |
| Glutathione-cleavable prodrug and methods of use thereof ML Brown, Y Kong, J Smith, K Wang, S Hou US Patent 10,023,551, 2018 | | 2018 |
| Small molecules for treating breast cancer S Dakshanamurthy, ML Brown, R Clarke, AN Shajahan-Haq, J Smith US Patent 9,359,299, 2016 | | 2016 |
| Treating Tamoxifen resistant breast cancer by inhibiting protein degradation J Smith ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015 | | 2015 |
Herman O. SintimRichard B. Wetherill Distinguished Professor, Purdue UniversityVerified email at purdue.edu