Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts M Pupo, A Pisano, R Lappano, MF Santolla, EM De Francesco, ... Environmental health perspectives 120 (8), 1177-1182, 2012 | 323 | 2012 |
HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs) EM De Francesco, R Lappano, MF Santolla, S Marsico, A Caruso, ... Breast Cancer Research 15, 1-18, 2013 | 260 | 2013 |
Cancer stem cells (CSCs): metabolic strategies for their identification and eradication EM De Francesco, F Sotgia, MP Lisanti Biochemical Journal 475 (9), 1611-1634, 2018 | 234 | 2018 |
Copper activates HIF-1α/GPER/VEGF signalling in cancer cells DC Rigiracciolo, A Scarpelli, R Lappano, A Pisano, MF Santolla, ... Oncotarget 6 (33), 34158, 2015 | 154 | 2015 |
GPER mediates activation of HIF1α/VEGF signaling by estrogens EM De Francesco, M Pellegrino, MF Santolla, R Lappano, E Ricchio, ... Cancer research 74 (15), 4053-4064, 2014 | 151 | 2014 |
Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells R Lappano, C Rosano, P De Marco, EM De Francesco, V Pezzi, ... Molecular and cellular endocrinology 320 (1-2), 162-170, 2010 | 143 | 2010 |
Crosstalk between Notch, HIF-1α and GPER in breast cancer EMT EM De Francesco, M Maggiolini, AM Musti International journal of molecular sciences 19 (7), 2011, 2018 | 136 | 2018 |
The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1α (HIF-1α) in breast cancer cells and cardiomyocytes AG Recchia, EM De Francesco, A Vivacqua, D Sisci, ML Panno, S Ando, ... Journal of Biological Chemistry 286 (12), 10773-10782, 2011 | 135 | 2011 |
The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes R Lappano, AG Recchia, EM De Francesco, T Angelone, MC Cerra, ... PloS one 6 (1), e16631, 2011 | 123 | 2011 |
GPER mediates the Egr-1 expression induced by 17β-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells A Vivacqua, E Romeo, P De Marco, EM De Francesco, S Abonante, ... Breast cancer research and treatment 133, 1025-1035, 2012 | 113 | 2012 |
Cross-talk between GPER and growth factor signaling R Lappano, P De Marco, EM De Francesco, A Chimento, V Pezzi, ... The Journal of steroid biochemistry and molecular biology 137, 50-56, 2013 | 100 | 2013 |
Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) EM De Francesco, G Bonuccelli, M Maggiolini, F Sotgia, MP Lisanti Oncotarget 8 (40), 67269, 2017 | 95 | 2017 |
GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment EM De Francesco, AH Sims, M Maggiolini, F Sotgia, MP Lisanti, ... Breast Cancer Research 19, 1-14, 2017 | 91 | 2017 |
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer MF Santolla, S Avino, M Pellegrino, EM De Francesco, P De Marco, ... Cell death & disease 6 (7), e1834-e1834, 2015 | 88 | 2015 |
GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response P De Marco, R Lappano, EMD Francesco, F Cirillo, M Pupo, S Avino, ... Scientific reports 6 (1), 24354, 2016 | 86 | 2016 |
NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness” G Bonuccelli, EM De Francesco, R de Boer, HB Tanowitz, MP Lisanti Oncotarget 8 (13), 20667, 2017 | 82 | 2017 |
GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells DC Rigiracciolo, A Scarpelli, R Lappano, A Pisano, MF Santolla, S Avino, ... Oncotarget 7 (1), 94, 2016 | 74 | 2016 |
Pregnancy augments G protein estrogen receptor (GPER) induced vasodilation in rat uterine arteries via the nitric oxide-cGMP signaling pathway T Tropea, EM De Francesco, D Rigiracciolo, M Maggiolini, M Wareing, ... PLoS One 10 (11), e0141997, 2015 | 73 | 2015 |
GPER, IGF‐IR, and EGFR transduction signaling are involved in stimulatory effects of zinc in breast cancer cells and cancer‐associated fibroblasts A Pisano, MF Santolla, EM De Francesco, P De Marco, DC Rigiracciolo, ... Molecular carcinogenesis 56 (2), 580-593, 2017 | 69 | 2017 |
Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy EM De Francesco, M Maggiolini, HB Tanowitz, F Sotgia, MP Lisanti Oncotarget 8 (34), 56126, 2017 | 65 | 2017 |