ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs J Ye, RB Rawson, R Komuro, X Chen, UP Davé, R Prywes, MS Brown, ... Molecular cell 6 (6), 1355-1364, 2000 | 2219 | 2000 |
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans MS Brown, J Ye, RB Rawson, JL Goldstein Cell 100 (4), 391-398, 2000 | 1707 | 2000 |
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment J Sakai, EA Duncan, RB Rawson, X Hua, MS Brown, JL Goldstein Cell 85 (7), 1037-1046, 1996 | 682 | 1996 |
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs RB Rawson, NG Zelenski, D Nijhawan, J Ye, J Sakai, MT Hasan, ... Molecular cell 1 (1), 47-57, 1997 | 596 | 1997 |
Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells J Sakai, RB Rawson, PJ Espenshade, D Cheng, AC Seegmiller, ... Molecular cell 2 (4), 505-514, 1998 | 531 | 1998 |
Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. DH Castrillon, P Gönczy, S Alexander, R Rawson, CG Eberhart, ... Genetics 135 (2), 489-505, 1993 | 445 | 1993 |
The SREBP pathway—insights from Insigs and insects RB Rawson Nature reviews Molecular cell biology 4 (8), 631-640, 2003 | 422 | 2003 |
Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila IY Dobrosotskaya, AC Seegmiller, MS Brown, JL Goldstein, RB Rawson Science 296 (5569), 879-883, 2002 | 369 | 2002 |
Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis JL Goldstein, RB Rawson, MS Brown Archives of biochemistry and biophysics 397 (2), 139-148, 2002 | 334 | 2002 |
The SREBP pathway in Drosophila: regulation by palmitate, not sterols AC Seegmiller, I Dobrosotskaya, JL Goldstein, YK Ho, MS Brown, ... Developmental cell 2 (2), 229-238, 2002 | 224 | 2002 |
Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage … RB Rawson, R DeBose-Boyd, JL Goldstein, MS Brown Journal of Biological Chemistry 274 (40), 28549-28556, 1999 | 202 | 1999 |
UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior. G Cenci, RB Rawson, G Belloni, DH Castrillon, M Tudor, R Petrucci, ... Genes & development 11 (7), 863-875, 1997 | 165 | 1997 |
Dual roles for cholesterol in mammalian cells F Xu, SD Rychnovsky, JD Belani, HH Hobbs, JC Cohen, RB Rawson Proceedings of the National Academy of Sciences 102 (41), 14551-14556, 2005 | 164 | 2005 |
Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins NG Zelenski, RB Rawson, MS Brown, JL Goldstein Journal of Biological Chemistry 274 (31), 21973-21980, 1999 | 144 | 1999 |
COPI activity coupled with fatty acid biosynthesis is required for viral replication S Cherry, A Kunte, H Wang, C Coyne, RB Rawson, N Perrimon PLoS pathogens 2 (10), e102, 2006 | 143 | 2006 |
Fatty acid auxotrophy in Drosophila larvae lacking SREBP AS Kunte, KA Matthews, RB Rawson Cell metabolism 3 (6), 439-448, 2006 | 141 | 2006 |
Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols D Yabe, ZP Xia, CM Adams, RB Rawson Proceedings of the National Academy of Sciences 99 (26), 16672-16677, 2002 | 131 | 2002 |
Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1 RB Rawson, D Cheng, MS Brown, JL Goldstein Journal of Biological Chemistry 273 (43), 28261-28269, 1998 | 126 | 1998 |
The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport J Sakai, RB Rawson Current opinion in lipidology 12 (3), 261-266, 2001 | 96 | 2001 |
The site-2 protease RB Rawson Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (12), 2801-2807, 2013 | 81 | 2013 |