Articles with public access mandates - Assistant Professor Inge R. Holtman, PhDLearn more
Not available anywhere: 2
CD 14 is a key organizer of microglial responses to CNS infection and injury
H Janova, C Böttcher, IR Holtman, T Regen, D van Rossum, A Götz, ...
Glia 64 (4), 635-649, 2016
Mandates: US National Institutes of Health, German Research Foundation
Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types
IR Holtman, CK Glass, A Nott
Microglia: Physiology, Pathophysiology and Therapeutic Potential, 531-544, 2024
Mandates: UK Medical Research Council
Available somewhere: 25
An environment-dependent transcriptional network specifies human microglia identity
D Gosselin, D Skola, NG Coufal, IR Holtman, JCM Schlachetzki, E Sajti, ...
Science 356 (6344), eaal3222, 2017
Mandates: US National Institutes of Health, Canadian Institutes of Health Research …
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
IR Holtman, DD Raj, JA Miller, W Schaafsma, Z Yin, N Brouwer, PD Wes, ...
Acta neuropathologica communications 3, 1-18, 2015
Mandates: Netherlands Organisation for Scientific Research
Brain cell type–specific enhancer–promoter interactome maps and disease-risk association
A Nott, IR Holtman, NG Coufal, JCM Schlachetzki, M Yu, R Hu, CZ Han, ...
Science 366 (6469), 1134-1139, 2019
Mandates: US National Institutes of Health, American Heart Association, Netherlands …
A novel microglial subset plays a key role in myelinogenesis in developing brain
A Wlodarczyk, IR Holtman, M Krueger, N Yogev, J Bruttger, R Khorooshi, ...
The EMBO journal 36 (22), 3292-3308, 2017
Mandates: Danish Council for Technology and Innovation, Danish Council for Independent …
Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1
F Szulzewsky, A Pelz, X Feng, M Synowitz, D Markovic, T Langmann, ...
PloS one 10 (2), e0116644, 2015
Mandates: US National Institutes of Health, German Research Foundation
Transcriptional control of microglia phenotypes in health and disease
IR Holtman, D Skola, CK Glass
The Journal of clinical investigation 127 (9), 3220-3229, 2017
Mandates: US National Institutes of Health
Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function
VM Link, SH Duttke, HB Chun, IR Holtman, E Westin, MA Hoeksema, ...
Cell 173 (7), 1796-1809. e17, 2018
Mandates: US National Institutes of Health, German Research Foundation
Priming of microglia in a DNA-repair deficient model of accelerated aging
DDA Raj, D Jaarsma, IR Holtman, M Olah, FM Ferreira, W Schaafsma, ...
Neurobiology of aging 35 (9), 2147-2160, 2014
Mandates: US National Institutes of Health, European Commission, Royal Netherlands …
Diet-regulated production of PDGFcc by macrophages controls energy storage
N Cox, L Crozet, IR Holtman, PL Loyher, T Lazarov, JB White, E Mass, ...
Science 373 (6550), eabe9383, 2021
Mandates: US National Institutes of Health
Identification of a conserved and acute neurodegeneration‐specific microglial transcriptome in the zebrafish
N Oosterhof, IR Holtman, LE Kuil, HC van der Linde, EWGM Boddeke, ...
Glia 65 (1), 138-149, 2017
Mandates: Netherlands Organisation for Health Research and Development
Enhanced microglial pro‐inflammatory response to lipopolysaccharide correlates with brain infiltration and blood–brain barrier dysregulation in a mouse model of telomere shortening
DDA Raj, J Moser, SMA van der Pol, RP van Os, IR Holtman, N Brouwer, ...
Aging cell 14 (6), 1003-1013, 2015
Mandates: German Research Foundation, Netherlands Organisation for Scientific Research
Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model
A Scheffold, IR Holtman, S Dieni, N Brouwer, SF Katz, BMC Jebaraj, ...
Acta neuropathologica communications 4, 1-17, 2016
Mandates: German Research Foundation, Federal Ministry of Education and Research, Germany
Heritability enrichment implicates microglia in Parkinson's disease pathogenesis
MS Andersen, S Bandres‐Ciga, RH Reynolds, J Hardy, M Ryten, L Krohn, ...
Annals of neurology 89 (5), 942-951, 2021
Mandates: US National Institutes of Health, Alzheimers's UK, UK Medical Research …
Mechanisms underlying divergent responses of genetically distinct macrophages to IL-4
MA Hoeksema, Z Shen, IR Holtman, A Zheng, NJ Spann, I Cobo, ...
Science advances 7 (25), eabf9808, 2021
Mandates: US National Institutes of Health, American Heart Association, Netherlands …
Type I interferon‐activated microglia are critical for neuromyelitis optica pathology
A Wlodarczyk, R Khorooshi, J Marczynska, IR Holtman, M Burton, ...
Glia 69 (4), 943-953, 2021
Mandates: Danish Council for Independent Research, European Commission
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity
BR Fixsen, CZ Han, Y Zhou, NJ Spann, P Saisan, Z Shen, C Balak, ...
Nature immunology 24 (7), 1188-1199, 2023
Mandates: US National Institutes of Health
Genetic insights into immune mechanisms of Alzheimer’s and Parkinson’s disease
A Nott, IR Holtman
Frontiers in immunology 14, 1168539, 2023
Mandates: Alzheimers's UK, UK Medical Research Council
Aging, microglia and cytoskeletal regulation are key factors in the pathological evolution of the APP23 mouse model for Alzheimer's disease
L Janssen, ML Dubbelaar, IR Holtman, J de Boer-Bergsma, BJL Eggen, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (2), 395-405, 2017
Mandates: Research Foundation (Flanders)
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