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Senthilvelrajan Kaniyappan
Senthilvelrajan Kaniyappan
Lab head/Group leader at Neural Signalling section at Roche
Verified email at roche.com
Title
Cited by
Cited by
Year
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
108992021
The release and trans-synaptic transmission of Tau via exosomes
Y Wang, V Balaji, S Kaniyappan, L Krüger, S Irsen, K Tepper, ...
Molecular neurodegeneration 12, 1-25, 2017
6472017
Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity
S Kumar, K Tepper, S Kaniyappan, J Biernat, S Wegmann, ...
Journal of biological chemistry 289 (29), 20318-20332, 2014
912014
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability
S Kaniyappan, RR Chandupatla, EM Mandelkow, E Mandelkow
Alzheimer's & Dementia 13 (11), 1270-1291, 2017
862017
FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
S Kaniyappan, K Tepper, J Biernat, RR Chandupatla, S Hübschmann, ...
Molecular Neurodegeneration 15 (1), 39, 2020
502020
Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates
J Hochmair, C Exner, M Franck, A Dominguez‐Baquero, L Diez, ...
The EMBO Journal 41 (11), e108882, 2022
432022
A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications
F Drepper, J Biernat, S Kaniyappan, HE Meyer, EM Mandelkow, ...
Journal of Biological Chemistry 295 (52), 18213-18225, 2020
432020
C3G (RapGEF1), a regulator of actin dynamics promotes survival and myogenic differentiation of mouse mesenchymal cells.
RV Sasi Kumar K, Ramadhas A, Nayak SC, Kaniyappan S, Dayma K
Biochim Biophys Acta., 2015
38*2015
Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems
V Balaji, S Kaniyappan, E Mandelkow, Y Wang, EM Mandelkow
Autophagy 14 (12), 2139-2154, 2018
332018
Potent Tau aggregation inhibitor D‐peptides selected against Tau‐repeat 2 using mirror image phage display
M Malhis, S Kaniyappan, I Aillaud, RR Chandupatla, LM Ramirez, ...
ChemBioChem 22 (21), 3049-3059, 2021
242021
Novel antibody against low‐n oligomers of tau protein promotes clearance of tau in cells via lysosomes
RR Chandupatla, A Flatley, R Feederle, EM Mandelkow, S Kaniyappan
Alzheimer's & Dementia: Translational Research & Clinical Interventions 6 (1 …, 2020
222020
Suppressing tau aggregation and toxicity by an anti-aggregant tau fragment
GJ Pir, B Choudhary, S Kaniyappan, RR Chandupatla, E Mandelkow, ...
Molecular neurobiology 56, 3751-3767, 2019
172019
The plasma factor XIII heterotetrameric complex structure: unexpected unequal pairing within a symmetric complex
S Singh, A Nazabal, S Kaniyappan, JL Pellequer, AS Wolberg, D Imhof, ...
Biomolecules 9 (12), 765, 2019
162019
A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro
I Aillaud, S Kaniyappan, RR Chandupatla, LM Ramirez, S Alkhashrom, ...
Alzheimer's Research & Therapy 14 (1), 15, 2022
142022
Disruption of structural disulfides of coagulation FXIII-B subunit; functional implications for a rare bleeding disorder
S Singh, MS Akhter, J Dodt, A Sharma, S Kaniyappan, H Yadegari, ...
International Journal of Molecular Sciences 20 (8), 1956, 2019
82019
Spreading of tau protein does not depend on aggregation propensity
S Rodrigues, M Anglada-Huguet, K Hochgräfe, S Kaniyappan, ...
Journal of Molecular Neuroscience 73 (9), 693-712, 2023
52023
Purification and characterization of low-n tau oligomers
S Kaniyappan, RR Chandupatla, E Mandelkow
Amyloid Proteins: Methods and Protocols, 99-111, 2018
32018
Discovery of Orally Available and Brain Penetrant AEP Inhibitors
D Krummenacher, W He, B Kuhn, C Schnider, A Beurier, V Brom, ...
Journal of Medicinal Chemistry 66 (24), 17026-17043, 2023
22023
Reversal of tau-dependent cognitive decay by blocking adenosine A1 receptors: comparison of transgenic mouse models with different levels of tauopathy
M Anglada-Huguet, H Endepols, A Sydow, R Hilgers, B Neumaier, ...
International journal of molecular sciences 24 (11), 9260, 2023
22023
Pre-stress of actin cortices is important for the viscoelastic response of living cells
A Cordes, H Witt, A Gallemí-Pérez, B Brückner, F Grimm, M Vache, ...
BioRxiv, 783613, 2019
12019
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Articles 1–20