Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells HF Farin, JH Van Es, H Clevers Gastroenterology 143 (6), 1518-1529. e7, 2012 | 728 | 2012 |
Replacement of lost Lgr5-positive stem cells through plasticity of their enterocyte-lineage daughters PW Tetteh, O Basak, HF Farin, K Wiebrands, K Kretzschmar, H Begthel, ... Cell stem cell 18 (2), 203-213, 2016 | 615 | 2016 |
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny X Yin, HF Farin, JH Van Es, H Clevers, R Langer, JM Karp Nature methods 11 (1), 106-112, 2014 | 589 | 2014 |
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche HF Farin, I Jordens, MH Mosa, O Basak, J Korving, DVF Tauriello, ... Nature 530 (7590), 340-343, 2016 | 572 | 2016 |
Controlled gene expression in primary Lgr5 organoid cultures BK Koo, DE Stange, T Sato, W Karthaus, HF Farin, M Huch, JH Van Es, ... Nature methods 9 (1), 81-83, 2012 | 370 | 2012 |
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ HF Farin, WR Karthaus, P Kujala, M Rakhshandehroo, G Schwank, ... Journal of Experimental Medicine 211 (7), 1393-1405, 2014 | 295 | 2014 |
3D model for CAR‐mediated cytotoxicity using patient‐derived colorectal cancer organoids TE Schnalzger, MHP de Groot, C Zhang, MH Mosa, BE Michels, J Röder, ... The EMBO journal 38 (12), e100928, 2019 | 274 | 2019 |
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis C Heichler, K Scheibe, A Schmied, CI Geppert, B Schmid, S Wirtz, ... Gut 69 (7), 1269-1282, 2020 | 246 | 2020 |
TTC7A mutations disrupt intestinal epithelial apicobasal polarity AE Bigorgne, HF Farin, R Lemoine, N Mahlaoui, N Lambert, M Gil, ... The Journal of clinical investigation 124 (1), 328-337, 2014 | 211 | 2014 |
Plasticity within stem cell hierarchies in mammalian epithelia PW Tetteh, HF Farin, H Clevers Trends in cell biology 25 (2), 100-108, 2015 | 193 | 2015 |
Pooled in vitro and in vivo CRISPR-Cas9 screening identifies tumor suppressors in human colon organoids BE Michels, MH Mosa, BI Streibl, T Zhan, C Menche, K Abou-El-Ardat, ... Cell Stem Cell 26 (5), 782-792. e7, 2020 | 169 | 2020 |
Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation R Singh, WM Hoogaars, P Barnett, T Grieskamp, MS Rana, H Buermans, ... Cellular and Molecular Life Sciences 69, 1377-1389, 2012 | 166 | 2012 |
Generation of L cells in mouse and human small intestine organoids N Petersen, F Reimann, S Bartfeld, HF Farin, FC Ringnalda, RGJ Vries, ... Diabetes 63 (2), 410-420, 2014 | 157 | 2014 |
Tbx20 Interacts With Smads to Confine Tbx2 Expression to the Atrioventricular Canal R Singh, T Horsthuis, HF Farin, T Grieskamp, J Norden, M Petry, ... Circulation research 105 (5), 442-452, 2009 | 132 | 2009 |
Transcriptional Repression by the T-box Proteins Tbx18 and Tbx15 Depends on Groucho Corepressors*♦ HF Farin, M Bussen, MK Schmidt, MK Singh, K Schuster-Gossler, ... Journal of Biological Chemistry 282 (35), 25748-25759, 2007 | 109 | 2007 |
Intestinal inflammation and dysregulated immunity in patients with inherited caspase-8 deficiency AS Lehle, HF Farin, B Marquardt, BE Michels, T Magg, Y Li, Y Liu, ... Gastroenterology 156 (1), 275-278, 2019 | 106 | 2019 |
Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells R Forster, K Chiba, L Schaeffer, SG Regalado, CS Lai, Q Gao, S Kiani, ... Stem cell reports 2 (6), 838-852, 2014 | 101 | 2014 |
YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis K Taniguchi, T Moroishi, PR De Jong, M Krawczyk, BM Grebbin, H Luo, ... Proceedings of the National Academy of Sciences 114 (7), 1643-1648, 2017 | 95 | 2017 |
A Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer MH Mosa, BE Michels, C Menche, AM Nicolas, T Darvishi, FR Greten, ... Cancer research 80 (24), 5569-5582, 2020 | 91 | 2020 |
TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in Cousin syndrome E Lausch, P Hermanns, HF Farin, Y Alanay, S Unger, S Nikkel, ... The American Journal of Human Genetics 83 (5), 649-655, 2008 | 90 | 2008 |