EditR: a method to quantify base editing from Sanger sequencing MG Kluesner, DA Nedveck, WS Lahr, JR Garbe, JE Abrahante, ... The CRISPR journal 1 (3), 239-250, 2018 | 380 | 2018 |
TALEN-based gene correction for epidermolysis bullosa MJ Osborn, CG Starker, AN McElroy, BR Webber, MJ Riddle, L Xia, ... Molecular Therapy 21 (6), 1151-1159, 2013 | 328 | 2013 |
Evaluation of TCR gene editing achieved by TALENs, CRISPR/Cas9, and megaTAL nucleases MJ Osborn, BR Webber, F Knipping, C Lonetree, N Tennis, AP DeFeo, ... Molecular Therapy 24 (3), 570-581, 2016 | 265 | 2016 |
Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors BR Webber, C Lonetree, MG Kluesner, MJ Johnson, EJ Pomeroy, ... Nature communications 10 (1), 5222, 2019 | 190 | 2019 |
A genetically engineered primary human natural killer cell platform for cancer immunotherapy EJ Pomeroy, JT Hunzeker, MG Kluesner, WS Lahr, BA Smeester, ... Molecular Therapy 28 (1), 52-63, 2020 | 146 | 2020 |
Fanconi anemia gene editing by the CRISPR/Cas9 system MJ Osborn, R Gabriel, BR Webber, AP DeFeo, AN McElroy, J Jarjour, ... Human gene therapy 26 (2), 114-126, 2015 | 126 | 2015 |
Efficient targeted integration directed by short homology in zebrafish and mammalian cells WA Wierson, JM Welker, MP Almeida, CM Mann, DA Webster, ME Torrie, ... Elife 9, e53968, 2020 | 112 | 2020 |
Rapid DNA replication origin licensing protects stem cell pluripotency JP Matson, R Dumitru, P Coryell, RM Baxley, W Chen, K Twaroski, ... Elife 6, e30473, 2017 | 100 | 2017 |
Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome) J Tolar, IH Park, L Xia, CJ Lees, B Peacock, B Webber, RT McElmurry, ... Blood, The Journal of the American Society of Hematology 117 (3), 839-847, 2011 | 96 | 2011 |
CRISPR/Cas9-based genetic correction for recessive dystrophic epidermolysis bullosa BR Webber, MJ Osborn, AN McElroy, K Twaroski, C Lonetree, AP DeFeo, ... NPJ Regenerative medicine 1 (1), 1-11, 2016 | 95 | 2016 |
Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments ED Tabdanov, NJ Rodríguez-Merced, AX Cartagena-Rivera, VV Puram, ... Nature communications 12 (1), 2815, 2021 | 92 | 2021 |
Base editor correction of COL7A1 in recessive dystrophic epidermolysis bullosa patient-derived fibroblasts and iPSCs MJ Osborn, GA Newby, AN McElroy, F Knipping, SC Nielsen, MJ Riddle, ... Journal of Investigative Dermatology 140 (2), 338-347. e5, 2020 | 92 | 2020 |
CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells MG Kluesner, WS Lahr, C Lonetree, BA Smeester, X Qiu, NJ Slipek, ... Nature communications 12 (1), 2437, 2021 | 77 | 2021 |
Engineering of primary human B cells with CRISPR/Cas9 targeted nuclease MJ Johnson, K Laoharawee, WS Lahr, BR Webber, BS Moriarity Scientific Reports 8 (1), 12144, 2018 | 70 | 2018 |
Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent stem cells MG Angelos, PN Ruh, BR Webber, RH Blum, CD Ryan, L Bendzick, ... Blood, The Journal of the American Society of Hematology 129 (26), 3428-3439, 2017 | 64 | 2017 |
Highly multiplexed genome engineering using CRISPR/Cas9 gRNA arrays M Kurata, NK Wolf, WS Lahr, MT Weg, MG Kluesner, S Lee, K Hui, ... PLoS one 13 (9), e0198714, 2018 | 63 | 2018 |
Intracellular genomic transplant and methods of therapy B Moriarity, B Webber, RS McIvor, M Choudhry, SA Rosenberg, ... US Patent 10,166,255, 2019 | 61 | 2019 |
Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade DC Palmer, BR Webber, Y Patel, MJ Johnson, CM Kariya, WS Lahr, ... Med 3 (10), 682-704. e8, 2022 | 51 | 2022 |
Modified cells and methods of therapy B Moriarity, B Webber, M Choudhry, RS McIvor, D Largaespada, ... US Patent 11,147,837, 2021 | 48 | 2021 |
Rapid generation of Col7a1−/− mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells BR Webber, KT O'Connor, RT McElmurry, EN Durgin, CR Eide, CJ Lees, ... Laboratory investigation 97 (10), 1218-1224, 2017 | 45 | 2017 |