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Christian M. Metallo
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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
CM Metallo, PA Gameiro, EL Bell, KR Mattaini, J Yang, K Hiller, ...
Nature 481 (7381), 380-384, 2012
19302012
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
C Commisso, SM Davidson, RG Soydaner-Azeloglu, SJ Parker, ...
Nature 497 (7451), 633-637, 2013
16162013
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ...
Nature genetics 43 (9), 869-874, 2011
11812011
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ...
Nature chemical biology 8 (10), 839-847, 2012
7832012
A roadmap for interpreting 13C metabolite labeling patterns from cells
JM Buescher, MR Antoniewicz, LG Boros, SC Burgess, H Brunengraber, ...
Current opinion in biotechnology 34, 189-201, 2015
6212015
Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
CA Lewis, SJ Parker, BP Fiske, D McCloskey, DY Gui, CR Green, ...
Molecular cell 55 (2), 253-263, 2014
5962014
Reductive carboxylation supports redox homeostasis during anchorage-independent growth
L Jiang, AA Shestov, P Swain, C Yang, SJ Parker, QA Wang, LS Terada, ...
Nature 532 (7598), 255-258, 2016
5802016
Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth
D Gaglio, CM Metallo, PA Gameiro, K Hiller, LS Danna, C Balestrieri, ...
Molecular systems biology 7 (1), 523, 2011
5652011
Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels
T Cordes, M Wallace, A Michelucci, AS Divakaruni, SC Sapcariu, C Sousa, ...
Journal of Biological Chemistry 291 (27), 14274-14284, 2016
4532016
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
RU Svensson, SJ Parker, LJ Eichner, MJ Kolar, M Wallace, SN Brun, ...
Nature medicine 22 (10), 1108-1119, 2016
4442016
Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
CR Green, M Wallace, AS Divakaruni, SA Phillips, AN Murphy, ...
Nature chemical biology 12 (1), 15-21, 2016
4252016
Mitochondria as biosynthetic factories for cancer proliferation
CS Ahn, CM Metallo
Cancer & metabolism 3, 1-10, 2015
3822015
Understanding metabolic regulation and its influence on cell physiology
CM Metallo, MG Vander Heiden
Molecular cell 49 (3), 388-398, 2013
3672013
ATP-citrate lyase controls a glucose-to-acetate metabolic switch
S Zhao, AM Torres, RA Henry, S Trefely, M Wallace, JV Lee, A Carrer, ...
Cell reports 17 (4), 1037-1052, 2016
3572016
Metabolic pathway alterations that support cell proliferation
MG Vander Heiden, SY Lunt, TL Dayton, BP Fiske, WJ Israelsen, ...
Cold Spring Harbor symposia on quantitative biology 76, 325-334, 2011
3352011
Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells
CM Metallo, JL Walther, G Stephanopoulos
Journal of biotechnology 144 (3), 167-174, 2009
3322009
Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis
T Valencia, JY Kim, S Abu-Baker, J Moscat-Pardos, CS Ahn, ...
Cancer cell 26 (1), 121-135, 2014
3122014
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer
X Liu, K Olszewski, Y Zhang, EW Lim, J Shi, X Zhang, J Zhang, H Lee, ...
Nature cell biology 22 (4), 476-486, 2020
3092020
Transaminase inhibition by 2-hydroxyglutarate impairs glutamate biosynthesis and redox homeostasis in glioma
SK McBrayer, JR Mayers, GJ DiNatale, DD Shi, J Khanal, AA Chakraborty, ...
Cell 175 (1), 101-116. e25, 2018
2972018
Regulation of substrate utilization by the mitochondrial pyruvate carrier
NM Vacanti, AS Divakaruni, CR Green, SJ Parker, RR Henry, TP Ciaraldi, ...
Molecular cell 56 (3), 425-435, 2014
2932014
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