Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism … NJ Hewitt, MJ Gómez Lechón, JB Houston, D Hallifax, HS Brown, ... Drug metabolism reviews 39 (1), 159-234, 2007 | 861 | 2007 |
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells C Aninat, A Piton, D Glaise, T Le Charpentier, S Langouët, F Morel, ... Drug metabolism and disposition 34 (1), 75-83, 2006 | 785 | 2006 |
The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics A Guillouzo, A Corlu, C Aninat, D Glaise, F Morel, C Guguen-Guillouzo Chemico-biological interactions 168 (1), 66-73, 2007 | 735 | 2007 |
Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Z Abdel-Razzak, P Loyer, A Fautrel, JC Gautier, L Corcos, B Turlin, ... Molecular pharmacology 44 (4), 707-715, 1993 | 676 | 1993 |
Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type C Guguen-Guillouzo, B Clément, G Baffet, C Beaumont, E Morel-Chany, ... Experimental cell research 143 (1), 47-54, 1983 | 657 | 1983 |
Liver cell models in in vitro toxicology. A Guillouzo Environmental health perspectives 106 (suppl 2), 511-532, 1998 | 528 | 1998 |
Inhibition of Cytochromes P-450 and Induction of Glutathione S-Transferases by Sulforaphane in Primary Human and Rat Hepatocytes K Mahéo, F Morel, S Langouët, H Kramer, E Le Ferrec, B Ketterer, ... Cancer Research 57 (17), 3649-3652, 1997 | 333 | 1997 |
Opposite regulation of human versus mouse apolipoprotein AI by fibrates in human apolipoprotein AI transgenic mice. L Berthou, N Duverger, F Emmanuel, S Langouët, J Auwerx, A Guillouzo, ... The Journal of clinical investigation 97 (11), 2408-2416, 1996 | 325 | 1996 |
Practical Aspects of the Validation of Toxicity Test Procedures: The Report and Recommendations of ECVAM Workshop 5, M Balls, BJ Blaauboer, JH Fentem, L Bruner, RD Combes, B Ekwall, ... Alternatives to laboratory animals 23 (1), 129-146, 1995 | 316 | 1995 |
The P-glycoprotein multidrug transporter O Fardel, V Lecureur, A Guillouzo General Pharmacology: The Vascular System 27 (8), 1283-1291, 1996 | 308 | 1996 |
Cell types involved in collagen and fibronectin production in normal and fibrotic human liver B Clement, JA Grimaud, JP Campion, Y Deugnier, A Guillouzo Hepatology 6 (2), 225-234, 1986 | 302 | 1986 |
General review on in vitro hepatocyte models and their applications C Guguen-Guillouzo, A Guillouzo Hepatocytes: methods and protocols, 1-40, 2010 | 299 | 2010 |
Modulation of functional activities in cultured rat hepatocytes C Guguen-Guillouzo, A Guillouzo Molecular and Cellular Biochemistry 53, 35-56, 1983 | 288 | 1983 |
Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells S Antherieu, C Chesne, R Li, S Camus, A Lahoz, L Picazo, M Turpeinen, ... Drug Metabolism and Disposition 38 (3), 516-525, 2010 | 287 | 2010 |
High yield preparation of isolated human adult hepatocytes by enzymatic perfusion of the liver C Guguen-Guillouzo, JP Campion, P Brissot, D Glaise, B Launois, ... Cell biology international reports 6 (6), 625-628, 1982 | 246 | 1982 |
Long-term co-cultures of adult human hepatocytes with rat liver epithelial cells: modulation of albumin secretion and accumulation of extracellular material B Clement, C Guguen-Guillouzo, JP Campion, D Glaise, M Bourel, ... Hepatology 4 (3), 373-380, 1984 | 223 | 1984 |
Metabolism: A Bottleneck in In Vitro Toxicological Test Development: The Report and Recommendations of ECVAM Workshop 54 S Coecke, H Ahr, BJ Blaauboer, S Bremer, S Casati, J Castell, R Combes, ... Alternatives to Laboratory Animals 34 (1), 49-84, 2006 | 220 | 2006 |
Expression of cytochrome P‐450 enzymes in cultured human hepatocytes F Morel, PH Beaune, D Ratanasavanh, JP FLINOIS, CS Yang, ... European Journal of Biochemistry 191 (2), 437-444, 1990 | 213 | 1990 |
Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies R Josse, C Aninat, D Glaise, J Dumont, V Fessard, F Morel, JM Poul, ... Drug Metabolism and Disposition 36 (6), 1111-1118, 2008 | 206 | 2008 |
Gene and protein characterization of the human glutathione S-transferase kappa and evidence for a peroxisomal localization F Morel, C Rauch, E Petit, A Piton, N Theret, B Coles, A Guillouzo Journal of biological chemistry 279 (16), 16246-16253, 2004 | 205 | 2004 |