A survey of current trends in computational drug repositioning J Li, S Zheng, B Chen, AJ Butte, SJ Swamidass, Z Lu Briefings in bioinformatics 17 (1), 2-12, 2016 | 551 | 2016 |
Chem2Bio2RDF: a semantic framework for linking and data mining chemogenomic and systems chemical biology data B Chen, X Dong, D Jiao, H Wang, Q Zhu, Y Ding, D Wild BMC bioinformatics 11 (1), 255, 2010 | 268 | 2010 |
Assessing Drug Target Association using Semantic Linked Data B Chen, Y Ding, DJ Wild PLoS Computational Biology 8 (7), e1002574, 2012 | 194 | 2012 |
Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis J Scheiber, B Chen, M Milik, SCK Sukuru, A Bender, D Mikhailov, ... Journal of chemical information and modeling 49 (2), 308-317, 2009 | 194 | 2009 |
Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets B Chen, L Ma, H Paik, M Sirota, W Wei, MS Chua, S So, AJ Butte Nature communications 8 (1), 16022, 2017 | 186 | 2017 |
Leveraging big data to transform target selection and drug discovery B Chen, AJ Butte Clinical Pharmacology & Therapeutics 99 (3), 285-297, 2016 | 186 | 2016 |
Leveraging big data to transform target selection and drug discovery B Chen, AJ Butte Clinical Pharmacology & Therapeutics 99 (3), 285-297, 2016 | 186 | 2016 |
PubChem as a source of polypharmacology B Chen, D Wild, R Guha Journal of chemical information and modeling 49 (9), 2044-2055, 2009 | 168 | 2009 |
The ChEMBL database as linked open data EL Willighagen, A Waagmeester, O Spjuth, P Ansell, AJ Williams, ... Journal of cheminformatics 5 (1), 1-12, 2013 | 148 | 2013 |
Predicting drug target interactions using meta-path-based semantic network analysis G Fu, Y Ding, A Seal, B Chen, Y Sun, E Bolton BMC bioinformatics 17 (1), 1-10, 2016 | 139 | 2016 |
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types K Yu, B Chen, D Aran, J Charalel, C Yau, DM Wolf, LJ Van ‘T Veer, ... Nature communications 10 (1), 3574, 2019 | 134 | 2019 |
Harnessing big ‘omics’ data and AI for drug discovery in hepatocellular carcinoma B Chen, L Garmire, DF Calvisi, MS Chua, RK Kelley, X Chen Nature Reviews Gastroenterology & Hepatology 17 (4), 238-251, 2020 | 117 | 2020 |
Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data K Liu, PA Newbury, BS Glicksberg, WZD Zeng, S Paithankar, ... Nature communications 10 (1), 2138, 2019 | 115 | 2019 |
Comparison of random forest and Pipeline Pilot Naive Bayes in prospective QSAR predictions. B Chen, RP Sheridan, V Hornak, JH Voigt Journal of Chemical Information and Modeling, 2012 | 115 | 2012 |
A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS M McMahon, A Contreras, M Holm, T Uechi, CM Forester, X Pang, ... Elife 8, e48847, 2019 | 114 | 2019 |
Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice S Zhang, X Song, D Cao, Z Xu, B Fan, L Che, J Hu, B Chen, M Dong, ... Journal of hepatology 67 (6), 1194-1203, 2017 | 109 | 2017 |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell … B Chen, W Wei, L Ma, B Yang, RM Gill, MS Chua, AJ Butte, S So Gastroenterology 152 (8), 2022-2036, 2017 | 98 | 2017 |
Relating hepatocellular carcinoma tumor samples and cell lines using gene expression data in translational research B Chen, M Sirota, H Fan-Minogue, D Hadley, AJ Butte BMC medical genomics 8 (2), 1-10, 2015 | 96 | 2015 |
MoCL: Data-driven Molecular Fingerprint via Knowledge-aware Contrastive Learning from Molecular Graph M Sun, J Xing, H Wang, B Chen, J Zhou Proceedings of the 27th ACM SIGKDD Conference on Knowledge Discovery & Data …, 2021 | 94 | 2021 |
Relating genes to function: identifying enriched transcription factors using the ENCODE ChIP-Seq significance tool RK Auerbach, B Chen, AJ Butte Bioinformatics 29 (15), 1922-1924, 2013 | 82 | 2013 |