Articles with public access mandates - Matthieu SchapiraLearn more
Not available anywhere: 20
Protein arginine methylation: from enigmatic functions to therapeutic targeting
Q Wu, M Schapira, CH Arrowsmith, D Barsyte-Lovejoy
Nature reviews Drug discovery 20 (7), 509-530, 2021
Mandates: Canadian Institutes of Health Research, Genome Canada, Wellcome Trust
Structure-based optimization of a small molecule antagonist of the interaction between WD repeat-containing protein 5 (WDR5) and mixed-lineage leukemia 1 (MLL1)
M Getlik, D Smil, C Zepeda-Velazquez, Y Bolshan, G Poda, H Wu, A Dong, ...
Journal of medicinal chemistry 59 (6), 2478-2496, 2016
Mandates: Canadian Institutes of Health Research, Genome Canada, Natural Sciences and …
Druggability of methyl-lysine binding sites
C Santiago, K Nguyen, M Schapira
Journal of computer-aided molecular design 25, 1171-1178, 2011
Mandates: Canadian Institutes of Health Research, Genome Canada
Structural chemistry of human RNA methyltransferases
M Schapira
ACS chemical biology 11 (3), 575-582, 2016
Mandates: Genome Canada, Wellcome Trust
Discovery of a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor by virtual screening
R Ferreira de Freitas, MS Eram, D Smil, MM Szewczyk, S Kennedy, ...
Journal of medicinal chemistry 59 (14), 6838-6847, 2016
Mandates: Genome Canada, Wellcome Trust
Structural genomics and drug discovery: all in the family
J Weigelt, LDB McBroom-Cerajewski, M Schapira, Y Zhao, ...
Current opinion in chemical biology 12 (1), 32-39, 2008
Mandates: Canadian Institutes of Health Research, Genome Canada
Discovery of a potent class I protein arginine methyltransferase fragment inhibitor
R Ferreira de Freitas, MS Eram, MM Szewczyk, H Steuber, D Smil, H Wu, ...
Journal of medicinal chemistry 59 (3), 1176-1183, 2016
Mandates: Wellcome Trust
Disease association and druggability of WD40 repeat proteins
R Song, ZD Wang, M Schapira
Journal of proteome research 16 (10), 3766-3773, 2017
Mandates: Genome Canada, Wellcome Trust
Methyltransferase inhibitors for modulation of the epigenome and beyond
M Schapira, CH Arrowsmith
Current Opinion in Chemical Biology 33, 81-87, 2016
Mandates: Genome Canada, Wellcome Trust
Pharmacophore screening of the protein data bank for specific binding site chemistry
V Campagna-Slater, AG Arrowsmith, Y Zhao, M Schapira
Journal of chemical information and modeling 50 (3), 358-367, 2010
Mandates: Canadian Institutes of Health Research, Genome Canada
The promise and peril of chemical probe negative controls
J Lee, M Schapira
ACS chemical biology 16 (4), 579-585, 2021
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada …
Structure-based view of the druggable genome
J Wang, S Yazdani, A Han, M Schapira
Drug Discovery Today 25 (3), 561-567, 2020
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada …
An integrative proteomic approach identifies novel cellular SMYD2 substrates
H Ahmed, S Duan, CH Arrowsmith, D Barsyte-Lovejoy, M Schapira
Journal of proteome research 15 (6), 2052-2059, 2016
Mandates: Genome Canada, Wellcome Trust
Finding inspiration in the protein data bank to chemically antagonize readers of the histone code
V Campagna‐Slater, M Schapira
Molecular Informatics 29 (4), 322-331, 2010
Mandates: Canadian Institutes of Health Research, Genome Canada
Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N‐substituted pantothenamides
B Li, W Tempel, D Smil, Y Bolshan, M Schapira, HW Park
Proteins: Structure, Function, and Bioinformatics 81 (8), 1466-1472, 2013
Mandates: US National Institutes of Health, Canadian Institutes of Health Research …
Building skeletally diverse architectures on the Indoline Scaffold: The discovery of a chemical probe of focal adhesion kinase signaling networks
M Prakesch, K Bijian, V Campagna-Slater, S Quevillon, R Joseph, ...
Bioorganic & medicinal chemistry 16 (21), 9596-9602, 2008
Mandates: Canadian Institutes of Health Research, Genome Canada, Ontario Institute for …
Structure–Activity Relationship of USP5 Inhibitors
MK Mann, CA Zepeda-Velázquez, H González-Álvarez, A Dong, T Kiyota, ...
Journal of medicinal chemistry 64 (20), 15017-15036, 2021
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada
Discovery of a novel DCAF1 ligand using a drug–target interaction prediction model: generalizing machine learning to new drug targets
SW Kimani, J Owen, SR Green, F Li, Y Li, A Dong, PJ Brown, S Ackloo, ...
Journal of Chemical Information and Modeling 63 (13), 4070-4078, 2023
Mandates: US Department of Energy, US National Institutes of Health, Genome Canada …
Structural diversity of the epigenetics pocketome
A Cabaye, KT Nguyen, L Liu, V Pande, M Schapira
Proteins: Structure, Function, and Bioinformatics 83 (7), 1316-1326, 2015
Mandates: Genome Canada, Wellcome Trust
Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2
M Eguida, G Bret, F Sindt, F Li, I Chau, S Ackloo, C Arrowsmith, ...
Journal of Chemical Information and Modeling, 2024
Mandates: Michael J Fox Foundation
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