Articles with public access mandates - John A. TallaricoLearn more
Available somewhere: 30
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
KJ Mavrakis, ER McDonald III, MR Schlabach, E Billy, GR Hoffman, ...
Science 351 (6278), 1208-1213, 2016
Mandates: US Department of Energy, US National Institutes of Health
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
JN Spradlin, X Hu, CC Ward, SM Brittain, MD Jones, L Ou, M To, ...
Nature chemical biology 15 (7), 747-755, 2019
Mandates: US National Institutes of Health, Chan Zuckerberg Initiative
Natural products reveal cancer cell dependence on oxysterol-binding proteins
AWG Burgett, TB Poulsen, K Wangkanont, DR Anderson, C Kikuchi, ...
Nature chemical biology 7 (9), 639-647, 2011
Mandates: US National Institutes of Health
Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications
CC Ward, JI Kleinman, SM Brittain, PS Lee, CYS Chung, K Kim, Y Petri, ...
ACS chemical biology 14 (11), 2430-2440, 2019
Mandates: US National Institutes of Health
Selective and specific inhibition of the Plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
D Hoepfner, CW McNamara, CS Lim, C Studer, R Riedl, T Aust, ...
Cell host & microbe 11 (6), 654-663, 2012
Mandates: US National Institutes of Health
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling
X Cai, Y Xu, AK Cheung, RC Tomlinson, A Alcázar-Román, L Murphy, ...
Chemistry & biology 20 (7), 912-921, 2013
Mandates: US National Institutes of Health
Deubiquitinase-targeting chimeras for targeted protein stabilization
NJ Henning, L Boike, JN Spradlin, CC Ward, G Liu, E Zhang, BP Belcher, ...
Nature chemical biology 18 (4), 412-421, 2022
Mandates: US National Science Foundation, US National Institutes of Health
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62
R DeJesus, F Moretti, G McAllister, Z Wang, P Bergman, S Liu, E Frias, ...
Elife 5, e17290, 2016
Mandates: US National Institutes of Health
Discovery of a covalent FEM1B recruiter for targeted protein degradation applications
NJ Henning, AG Manford, JN Spradlin, SM Brittain, E Zhang, JM McKenna, ...
Journal of the American Chemical Society 144 (2), 701-708, 2022
Mandates: US National Institutes of Health, Howard Hughes Medical Institute
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function
M Luo, JN Spradlin, L Boike, B Tong, SM Brittain, JM McKenna, ...
Cell chemical biology 28 (4), 559-566. e15, 2021
Mandates: US National Institutes of Health
Bardoxolone conjugation enables targeted protein degradation of BRD4
B Tong, M Luo, Y Xie, JN Spradlin, JA Tallarico, JM McKenna, M Schirle, ...
Scientific reports 10 (1), 15543, 2020
Mandates: US National Institutes of Health
Manumycin polyketides act as molecular glues between UBR7 and P53
Y Isobe, M Okumura, LM McGregor, SM Brittain, MD Jones, X Liang, ...
Nature chemical biology 16 (11), 1189-1198, 2020
Mandates: US National Institutes of Health
Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC
L Boike, AG Cioffi, FC Majewski, NJ Henning, MD Jones, G Liu, ...
Cell chemical biology 28 (1), 4-13. e17, 2021
Mandates: US National Science Foundation, US National Institutes of Health
A nimbolide-based kinase degrader preferentially degrades oncogenic BCR-ABL
B Tong, JN Spradlin, LFT Novaes, E Zhang, X Hu, M Moeller, SM Brittain, ...
ACS chemical biology 15 (7), 1788-1794, 2020
Mandates: US National Institutes of Health
Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon
T Junne, J Wong, C Studer, T Aust, BW Bauer, M Beibel, B Bhullar, ...
Journal of cell science 128 (6), 1217-1229, 2015
Mandates: Swiss National Science Foundation, US National Institutes of Health, Howard …
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma
NT Ross, F Lohmann, S Carbonneau, A Fazal, WA Weihofen, S Gleim, ...
Nature chemical biology 16 (1), 50-59, 2020
Mandates: Swiss National Science Foundation, UK Medical Research Council
Accelerating antiviral drug discovery: lessons from COVID-19
A von Delft, MD Hall, AD Kwong, LA Purcell, KS Saikatendu, U Schmitz, ...
Nature Reviews Drug Discovery 22 (7), 585-603, 2023
Mandates: US National Institutes of Health, National Institute for Health Research, UK …
Discovery of a ZIP7 inhibitor from a Notch pathway screen
E Nolin, S Gans, L Llamas, S Bandyopadhyay, SM Brittain, ...
Nature chemical biology 15 (2), 179-188, 2019
Mandates: US National Institutes of Health
Rational chemical design of molecular glue degraders
ES Toriki, JW Papatzimas, K Nishikawa, D Dovala, AO Frank, MJ Hesse, ...
ACS central science 9 (5), 915-926, 2023
Mandates: US National Science Foundation, US National Institutes of Health, Natural …
Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB
EA King, Y Cho, NS Hsu, D Dovala, JM McKenna, JA Tallarico, M Schirle, ...
Cell chemical biology 30 (4), 394-402. e9, 2023
Mandates: US National Science Foundation, US National Institutes of Health
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