Minimum information about a biosynthetic gene cluster MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ... Nature chemical biology 11 (9), 625-631, 2015 | 892 | 2015 |
Towards the sustainable discovery and development of new antibiotics M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ... Nature Reviews Chemistry 5 (10), 726-749, 2021 | 703 | 2021 |
Antibiotic drug discovery W Wohlleben, Y Mast, E Stegmann, N Ziemert Microbial biotechnology 9 (5), 541-548, 2016 | 208 | 2016 |
Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis S Donadio, M Sosio, E Stegmann, T Weber, W Wohlleben Molecular Genetics and Genomics 274, 40-50, 2005 | 94 | 2005 |
The biosynthesis of teicoplanin-type glycopeptide antibiotics: assignment of p450 mono-oxygenases to side chain cyclizations of glycopeptide a47934 B Hadatsch, D Butz, T Schmiederer, J Steudle, W Wohlleben, R Süssmuth, ... Chemistry & biology 14 (9), 1078-1089, 2007 | 86 | 2007 |
Genetic analysis of the balhimycin (vancomycin-type) oxygenase genes E Stegmann, S Pelzer, D Bischoff, O Puk, S Stockert, D Butz, K Zerbe, ... Journal of biotechnology 124 (4), 640-653, 2006 | 86 | 2006 |
Synthetic biology of secondary metabolite biosynthesis in actinomycetes: engineering precursor supply as a way to optimize antibiotic production W Wohlleben, Y Mast, G Muth, M Röttgen, E Stegmann, T Weber FEBS letters 586 (15), 2171-2176, 2012 | 75 | 2012 |
Actinomycetes: The antibiotics producers Y Mast, E Stegmann Antibiotics 8 (3), 105, 2019 | 73 | 2019 |
Overproduction of ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17 M Spohn, N Kirchner, A Kulik, A Jochim, F Wolf, P Muenzer, O Borst, ... Antimicrobial Agents and Chemotherapy 58 (10), 6185-6196, 2014 | 72 | 2014 |
Mining bacterial genomes for secondary metabolite gene clusters M Adamek, M Spohn, E Stegmann, N Ziemert Antibiotics: methods and protocols, 23-47, 2017 | 68 | 2017 |
Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis T Kittilä, C Kittel, J Tailhades, D Butz, M Schoppet, A Büttner, RJA Goode, ... Chemical Science 8 (9), 5992-6004, 2017 | 60 | 2017 |
Glycopeptide biosynthesis in the context of basic cellular functions E Stegmann, HJ Frasch, W Wohlleben Current opinion in microbiology 13 (5), 595-602, 2010 | 60 | 2010 |
Streptocollin, a Type IV Lanthipeptide Produced by Streptomyces collinus Tü 365 D Iftime, M Jasyk, A Kulik, JF Imhoff, E Stegmann, W Wohlleben, ... ChemBioChem 16 (18), 2615-2623, 2015 | 59 | 2015 |
Increased glycopeptide production after overexpression of shikimate pathway genes being part of the balhimycin biosynthetic gene cluster J Thykaer, J Nielsen, W Wohlleben, T Weber, M Gutknecht, AE Lantz, ... Metabolic Engineering 12 (5), 455-461, 2010 | 57 | 2010 |
The ABC transporter Tba of Amycolatopsis balhimycina is required for efficient export of the glycopeptide antibiotic balhimycin R Menges, G Muth, W Wohlleben, E Stegmann Applied microbiology and biotechnology 77, 125-134, 2007 | 54 | 2007 |
Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365 D Iftime, A Kulik, T Härtner, S Rohrer, THJ Niedermeyer, E Stegmann, ... Journal of Industrial Microbiology and Biotechnology 43 (2-3), 277-291, 2016 | 52 | 2016 |
Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics A Greule, T Izoré, D Iftime, J Tailhades, M Schoppet, Y Zhao, M Peschke, ... Nature Communications 10 (1), 2613, 2019 | 51 | 2019 |
Self-resistance and cell wall composition in the glycopeptide producer Amycolatopsis balhimycina TF Schäberle, W Vollmer, HJ Frasch, S Hüttel, A Kulik, M Röttgen, ... Antimicrobial agents and chemotherapy 55 (9), 4283-4289, 2011 | 49 | 2011 |
Self-resistance mechanisms of actinomycetes producing lipid II-targeting antibiotics E Stegmann, HJ Frasch, R Kilian, R Pozzi International Journal of Medical Microbiology 305 (2), 190-195, 2015 | 43 | 2015 |
Challenges and advances in genetic manipulation of filamentous actinomycetes–the remarkable producers of specialized metabolites EM Musiol-Kroll, A Tocchetti, M Sosio, E Stegmann Natural Product Reports 36 (9), 1351-1369, 2019 | 42 | 2019 |