Articles with public access mandates - Uwe GretherLearn more
Not available anywhere: 1
Kinetic Profiling of Ligands and Fragments Binding to GPCRs by TR-FRET
DA Sykes, L Borrega-Roman, CR Harwood, B Hoare, JM Lochray, ...
Biophysical and Computational Tools in Drug Discovery, 1-32, 2021
Mandates: European Commission
Available somewhere: 26
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
M Soethoudt, U Grether, J Fingerle, TW Grim, F Fezza, L De Petrocellis, ...
Nature communications 8 (1), 13958, 2017
Mandates: US National Institutes of Health, Government of Italy
NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS
N Ouali Alami, C Schurr, F Olde Heuvel, L Tang, Q Li, A Tasdogan, ...
The EMBO journal 37 (16), e98697, 2018
Mandates: German Research Foundation
Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells
M Soethoudt, SC Stolze, MV Westphal, L Van Stralen, A Martella, ...
Journal of the American Chemical Society 140 (19), 6067-6075, 2018
Mandates: Netherlands Organisation for Scientific Research
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice
ED Mock, M Mustafa, O Gunduz-Cinar, R Cinar, GN Petrie, V Kantae, X Di, ...
Nature chemical biology 16 (6), 667-675, 2020
Mandates: US National Institutes of Health, Canadian Institutes of Health Research …
Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
M Maccarrone, V Di Marzo, J Gertsch, U Grether, AC Howlett, T Hua, ...
Pharmacological reviews 75 (5), 885-958, 2023
Mandates: US National Institutes of Health
Development of high-specificity fluorescent probes to enable cannabinoid type 2 receptor studies in living cells
RC Sarott, MV Westphal, P Pfaff, C Korn, DA Sykes, T Gazzi, B Brennecke, ...
Journal of the American Chemical Society 142 (40), 16953-16964, 2020
Mandates: Swiss National Science Foundation, US National Institutes of Health …
Selective cannabinoid 2 receptor agonists as potential therapeutic drugs for the treatment of endotoxin-induced uveitis
RF Porter, AM Szczesniak, JT Toguri, S Gebremeskel, B Johnston, ...
Molecules 24 (18), 3338, 2019
Mandates: Canadian Institutes of Health Research
The repertoire of small-molecule PET probes for neuroinflammation imaging: challenges and opportunities beyond TSPO
Z Chen, A Haider, J Chen, Z Xiao, L Gobbi, M Honer, U Grether, ...
Journal of medicinal chemistry 64 (24), 17656-17689, 2021
Mandates: Swiss National Science Foundation, US National Institutes of Health
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning
DF Nippa, K Atz, R Hohler, AT Müller, A Marx, C Bartelmus, G Wuitschik, ...
Nature Chemistry 16 (2), 239-248, 2024
Mandates: Swiss National Science Foundation
Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe
T Gazzi, B Brennecke, K Atz, C Korn, D Sykes, G Forn-Cuni, P Pfaff, ...
Chemical Science 13 (19), 5539-5545, 2022
Mandates: Swiss National Science Foundation, US National Institutes of Health …
Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease
S Ruiz de Martín Esteban, I Benito-Cuesta, I Terradillos, ...
Frontiers in pharmacology 13, 841766, 2022
Mandates: Government of Spain
Platform reagents enable synthesis of ligand-directed covalent probes: study of cannabinoid receptor 2 in live cells
M Kosar, DA Sykes, AEG Viray, RM Vitale, RC Sarott, RL Ganzoni, ...
Journal of the American Chemical Society 145 (28), 15094-15108, 2023
Mandates: Swiss National Science Foundation, UK Biotechnology and Biological Sciences …
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence
M Jiang, MCW Huizenga, JL Wirt, J Paloczi, A Amedi, RJ van den Berg, ...
Nature Communications 14 (1), 8039, 2023
Mandates: Netherlands Organisation for Scientific Research
Diverse chemotypes drive biased signaling by cannabinoid receptors
T Miljuš, FM Heydenreich, T Gazzi, A Kimbara, M Rogers-Evans, ...
bioRxiv, 2020.11. 09.375162, 2020
Mandates: Swiss National Science Foundation, Natural Sciences and Engineering Research …
Machine learning and computational chemistry for the endocannabinoid system
K Atz, W Guba, U Grether, G Schneider
Endocannabinoid Signaling: Methods and Protocols, 477-493, 2022
Mandates: Swiss National Science Foundation
Identifying opportunities for late-stage CH alkylation with high-throughput experimentation and in silico reaction screening
DF Nippa, K Atz, AT Müller, J Wolfard, C Isert, M Binder, O Scheidegger, ...
Communications Chemistry 6 (1), 256, 2023
Mandates: Swiss National Science Foundation
Evaluation of [18F]RoSMA-18-d6 as a CB2 PET Radioligand in Nonhuman Primates
A Haider, L Wang, L Gobbi, Y Li, A Chaudhary, X Zhou, J Chen, C Zhao, ...
ACS chemical neuroscience 14 (20), 3752-3760, 2023
Mandates: Swiss National Science Foundation
Drug derived fluorescent probes for the specific visualization of cannabinoid type 2 receptor-a toolbox approach
T Gazzi, B Brennecke, K Atz, C Korn, D Sykes, RC Sarott, MV Westphal, ...
Mandates: Swiss National Science Foundation, Government of Italy
Flipping the GPCR switch: Structure-based development of selective cannabinoid receptor 2 inverse agonists
M Kosar, RC Sarott, DA Sykes, AEG Viray, RM Vitale, N Tomašević, X Li, ...
ACS Central Science 10 (5), 956-968, 2024
Mandates: Swiss National Science Foundation, Austrian Science Fund, European Commission
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