| Programming cells by multiplex genome engineering and accelerated evolution HH Wang, FJ Isaacs, PA Carr, ZZ Sun, G Xu, CR Forest, GM Church Nature 460 (7257), 894-898, 2009 | 1860 | 2009 |
| Genomically recoded organisms expand biological functions MJ Lajoie, AJ Rovner, DB Goodman, HR Aerni, AD Haimovich, ... science 342 (6156), 357-360, 2013 | 966 | 2013 |
| Computational studies of gene regulatory networks: in numero molecular biology J Hasty, D McMillen, F Isaacs, JJ Collins Nature Reviews Genetics 2 (4), 268-279, 2001 | 817 | 2001 |
| Phenotypic consequences of promoter-mediated transcriptional noise WJ Blake, G Balázsi, MA Kohanski, FJ Isaacs, KF Murphy, Y Kuang, ... Molecular cell 24 (6), 853-865, 2006 | 729 | 2006 |
| Engineered riboregulators enable post-transcriptional control of gene expression FJ Isaacs, DJ Dwyer, C Ding, DD Pervouchine, CR Cantor, JJ Collins Nature biotechnology 22 (7), 841-847, 2004 | 724 | 2004 |
| Precise manipulation of chromosomes in vivo enables genome-wide codon replacement FJ Isaacs, PA Carr, HH Wang, MJ Lajoie, B Sterling, L Kraal, AC Tolonen, ... Science 333 (6040), 348-353, 2011 | 678 | 2011 |
| Prediction and measurement of an autoregulatory genetic module FJ Isaacs, J Hasty, CR Cantor, JJ Collins Proceedings of the National Academy of Sciences 100 (13), 7714-7719, 2003 | 574 | 2003 |
| A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes L Bazak, A Haviv, M Barak, J Jacob-Hirsch, P Deng, R Zhang, FJ Isaacs, ... Genome research 24 (3), 365-376, 2014 | 568 | 2014 |
| The real cost of sequencing: scaling computation to keep pace with data generation P Muir, S Li, S Lou, D Wang, DJ Spakowicz, L Salichos, J Zhang, ... Genome biology 17, 1-9, 2016 | 506 | 2016 |
| RNA synthetic biology FJ Isaacs, DJ Dwyer, JJ Collins Nature biotechnology 24 (5), 545-554, 2006 | 479 | 2006 |
| Recoded organisms engineered to depend on synthetic amino acids AJ Rovner, AD Haimovich, SR Katz, Z Li, MW Grome, BM Gassaway, ... Nature 518 (7537), 89-93, 2015 | 387 | 2015 |
| Designer gene networks: Towards fundamental cellular control J Hasty, F Isaacs, M Dolnik, D McMillen, JJ Collins Chaos: An Interdisciplinary Journal of Nonlinear Science 11 (1), 207-220, 2001 | 353 | 2001 |
| Engineering an allosteric transcription factor to respond to new ligands ND Taylor, AS Garruss, R Moretti, S Chan, MA Arbing, D Cascio, ... Nature methods 13 (2), 177-183, 2016 | 323 | 2016 |
| Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids M Amiram, AD Haimovich, C Fan, YS Wang, HR Aerni, I Ntai, DW Moonan, ... Nature biotechnology 33 (12), 1272-1279, 2015 | 287 | 2015 |
| The genome project-write JD Boeke, G Church, A Hessel, NJ Kelley, A Arkin, Y Cai, R Carlson, ... Science 353 (6295), 126-127, 2016 | 282 | 2016 |
| Potent noncovalent inhibitors of the main protease of SARS-CoV-2 from molecular sculpting of the drug perampanel guided by free energy perturbation calculations CH Zhang, EA Stone, M Deshmukh, JA Ippolito, MM Ghahremanpour, ... ACS central science 7 (3), 467-475, 2021 | 225 | 2021 |
| Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids RW Martin, BJ Des Soye, YC Kwon, J Kay, RG Davis, PM Thomas, ... Nature communications 9 (1), 1203, 2018 | 219 | 2018 |
| Tracking, tuning, and terminating microbial physiology using synthetic riboregulators JM Callura, DJ Dwyer, FJ Isaacs, CR Cantor, JJ Collins Proceedings of the National Academy of Sciences 107 (36), 15898-15903, 2010 | 218 | 2010 |
| Cell-free Protein Synthesis from a Release Factor 1 Deficient Escherichia coli Activates Efficient and Multiple Site-specific Nonstandard Amino Acid Incorporation SH Hong, I Ntai, AD Haimovich, NL Kelleher, FJ Isaacs, MC Jewett ACS synthetic biology 3 (6), 398-409, 2014 | 166 | 2014 |
| Hydrogel-based biocontainment of bacteria for continuous sensing and computation TC Tang, E Tham, X Liu, K Yehl, AJ Rovner, H Yuk, C de la Fuente-Nunez, ... Nature Chemical Biology 17 (6), 724-731, 2021 | 158 | 2021 |