Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide Y Tal-Gan, DM Stacy, MK Foegen, DW Koenig, HE Blackwell Journal of the American Chemical Society 135 (21), 7869-7882, 2013 | 149 | 2013 |
Microwave-assisted solid-phase aza-peptide synthesis: aza scan of a PKB/Akt inhibitor using aza-arginine and aza-proline precursors NS Freeman, Y Tal-Gan, S Klein, A Levitzki, C Gilon The Journal of Organic Chemistry 76 (9), 3078-3085, 2011 | 73 | 2011 |
Highly Stable, Amide‐Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus Y Tal‐Gan, M Ivancic, G Cornilescu, T Yang, HE Blackwell Angewandte Chemie 128 (31), 9059-9063, 2016 | 71 | 2016 |
Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing … Y Tal-Gan, M Ivancic, G Cornilescu, CC Cornilescu, HE Blackwell Journal of the American Chemical Society 135 (49), 18436-18444, 2013 | 63 | 2013 |
Simplified AIP‐II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors JK Vasquez, Y Tal‐Gan, G Cornilescu, KA Tyler, HE Blackwell ChemBioChem 18 (4), 413-423, 2017 | 58 | 2017 |
Structure–Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation T Yang, Y Tal-Gan, AE Paharik, AR Horswill, HE Blackwell ACS chemical biology 11 (7), 1982-1991, 2016 | 58 | 2016 |
Nanoporous superhydrophobic coatings that promote the extended release of water-labile quorum sensing inhibitors and enable long-term modulation of quorum sensing in … MJ Kratochvil, Y Tal-Gan, T Yang, HE Blackwell, DM Lynn ACS biomaterials science & engineering 1 (10), 1039-1049, 2015 | 55 | 2015 |
Structure–Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus pneumoniae Reveal Motifs Critical for Intra-group and Cross … Y Yang, B Koirala, LA Sanchez, NR Phillips, SR Hamry, Y Tal-Gan ACS chemical biology 12 (4), 1141-1151, 2017 | 54 | 2017 |
Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors … Y Tal-Gan, M Ivancic, G Cornilescu, HE Blackwell Organic & biomolecular chemistry 14 (1), 113-121, 2016 | 50 | 2016 |
Surface Coatings that Promote Rapid Release of Peptide‐Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus AH Broderick, DM Stacy, Y Tal‐Gan, MJ Kratochvil, HE Blackwell, ... Advanced healthcare materials 3 (1), 97-105, 2014 | 44 | 2014 |
N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus … Y Tal-Gan, DM Stacy, HE Blackwell Chemical Communications 50 (23), 3000-3003, 2014 | 42 | 2014 |
Novel method for the synthesis of urea backbone cyclic peptides using new Alloc‐protected glycine building units M Hurevich, Y Tal‐Gan, S Klein, Y Barda, A Levitzki, C Gilon Journal of Peptide Science: An Official Publication of the European Peptide …, 2010 | 39 | 2010 |
Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in Streptococcus pneumoniae Y Yang, J Lin, A Harrington, G Cornilescu, GW Lau, Y Tal-Gan Proceedings of the National Academy of Sciences 117 (3), 1689-1699, 2020 | 37 | 2020 |
Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria DN McBrayer, CD Cameron, Y Tal-Gan Organic & biomolecular chemistry 18 (37), 7273-7290, 2020 | 36 | 2020 |
Backbone cyclic peptide inhibitors of protein kinase B (PKB/Akt) Y Tal-Gan, M Hurevich, S Klein, A Ben-Shimon, D Rosenthal, C Hazan, ... Journal of medicinal chemistry 54 (14), 5154-5164, 2011 | 36 | 2011 |
Structure–Activity Relationships of the Competence Stimulating Peptide in Streptococcus mutans Reveal Motifs Critical for Membrane Protease SepM Recognition … CR Bikash, SR Hamry, Y Tal-Gan ACS infectious diseases 4 (9), 1385-1394, 2018 | 33 | 2018 |
Cyclic peptides that govern signal transduction pathways: from prokaryotes to multi-cellular organisms RW Mull, A Harrington, LA Sanchez, Y Tal-Gan Current topics in medicinal chemistry 18 (7), 625-644, 2018 | 32 | 2018 |
Development of a Dominant Negative Competence‐Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute … B Koirala, J Lin, GW Lau, Y Tal‐Gan ChemBioChem 19 (22), 2380-2386, 2018 | 27 | 2018 |
Metabolic Stability of Peptidomimetics: N‐Methyl and Aza Heptapeptide Analogs of a PKB/Akt Inhibitor Y Tal‐Gan, NS Freeman, S Klein, A Levitzki, C Gilon Chemical Biology & Drug Design 78 (5), 887-892, 2011 | 27 | 2011 |
Synthesis and structure–activity relationship studies of peptidomimetic PKB/Akt inhibitors: The significance of backbone interactions Y Tal-Gan, NS Freeman, S Klein, A Levitzki, C Gilon Bioorganic & medicinal chemistry 18 (8), 2976-2985, 2010 | 27 | 2010 |