| Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage T Nishikawa, D Edelstein, XL Du, S Yamagishi, T Matsumura, Y Kaneda, ... Nature 404 (6779), 787-790, 2000 | 5652 | 2000 |
| Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia P Xia, T Inoguchi, TS Kern, RL Engerman, PJ Oates, GL King Diabetes 43 (9), 1122-1129, 1994 | 628 | 1994 |
| Studies on the mechanism of ethanol-induced gastric damage in rats PJ Oates, JP Hakkinen Gastroenterology 94 (1), 10-21, 1988 | 513 | 1988 |
| Polyol pathway and diabetic peripheral neuropathy PJ Oates International review of neurobiology 50, 325-392, 2002 | 460 | 2002 |
| Aldose reductase, still a compelling target for diabetic neuropathy PJ Oates Current drug targets 9 (1), 14-36, 2008 | 299 | 2008 |
| Aldose reductase inhibitors: therapeutic implications for diabetic complications PJ Oates, BL Mylari Expert opinion on investigational drugs 8 (12), 2095-2119, 1999 | 245 | 1999 |
| The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy AD Hodgkinson, T Bartlett, PJ Oates, BA Millward, AG Demaine Diabetes 52 (3), 846-851, 2003 | 189 | 2003 |
| Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab) GJ Biessels, V Bril, NA Calcutt, NE Cameron, MA Cotter, R Dobrowsky, ... Journal of the Peripheral Nervous System 19 (2), 77-87, 2014 | 181 | 2014 |
| A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy W Sun, PJ Oates, JB Coutcher, C Gerhardinger, M Lorenzi Diabetes 55 (10), 2757-2762, 2006 | 168 | 2006 |
| Aldose Reductase–Deficient Mice Are Protected From Delayed Motor Nerve Conduction Velocity, Increased c-Jun NH2-Terminal Kinase Activation, Depletion of … ECM Ho, KSL Lam, YS Chen, JCW Yip, M Arvindakshan, SI Yamagishi, ... Diabetes 55 (7), 1946-1953, 2006 | 165 | 2006 |
| Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury R Ramasamy, PJ Oates, S Schaefer Diabetes 46 (2), 292-300, 1997 | 162 | 1997 |
| Central role for aldose reductase pathway in myocardial ischemic injury YC Hwang, M Kaneko, S Bakr, H Liao, Y Lu, ER Lewis, S Yan, S Ii, ... The FASEB journal 18 (11), 1192-1199, 2004 | 152 | 2004 |
| Aldose reductase inhibitors: recent developments D Raeburn, JE Souness, A Tomkinson, JA Karlsson, RM Freidinger, ... Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des …, 1993 | 148 | 1993 |
| Aldose reductase activation is a key component of myocardial response to ischemia YC Hwang, S Sato, JY Tsai, SD Yan, S Bakr, H Zhang, PJ Oates, ... The FASEB Journal 16 (2), 1-22, 2002 | 130 | 2002 |
| Diabetes induced decrease in detrusor smooth muscle force is associated with oxidative stress and overactivity of aldose reductase AK Changolkar, JA Hypolite, M Disanto, PJ Oates, AJ Wein, S Chacko The Journal of urology 173 (1), 309-313, 2005 | 114 | 2005 |
| X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase TA Pauly, JL Ekstrom, DA Beebe, B Chrunyk, D Cunningham, M Griffor, ... Structure 11 (9), 1071-1085, 2003 | 105 | 2003 |
| Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity S Gupta, E Chough, J Daley, P Oates, K Tornheim, NB Ruderman, ... American Journal of Physiology-Cell Physiology 282 (3), C560-C566, 2002 | 97 | 2002 |
| Aldose reductase, ocular diabetic complications and the development of topical Kinostat® PF Kador, M Wyman, PJ Oates Progress in retinal and eye research 54, 1-29, 2016 | 91 | 2016 |
| Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle JA Pfefferkorn, J Lou, ML Minich, KJ Filipski, M He, R Zhou, S Ahmed, ... Bioorganic & medicinal chemistry letters 19 (12), 3247-3252, 2009 | 85 | 2009 |
| A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl … BL Mylari, SJ Armento, DA Beebe, EL Conn, JB Coutcher, MS Dina, ... Journal of Medicinal Chemistry 48 (20), 6326-6339, 2005 | 81 | 2005 |