| Lysine‐targeting covalent inhibitors J Pettinger, K Jones, MD Cheeseman Angewandte Chemie International Edition 56 (48), 15200-15209, 2017 | 201 | 2017 |
| Demonstrating in-cell target engagement using a pirin protein degradation probe (CCT367766) NEA Chessum, SY Sharp, JJ Caldwell, AE Pasqua, B Wilding, ... Journal of medicinal chemistry 61 (3), 918-933, 2018 | 92 | 2018 |
| Flexible strategy for the synthesis of pyrrolizidine alkaloids TJ Donohoe, RE Thomas, MD Cheeseman, CL Rigby, G Bhalay, ... Organic letters 10 (16), 3615-3618, 2008 | 75 | 2008 |
| An irreversible inhibitor of HSP72 that unexpectedly targets lysine‐56 J Pettinger, YV Le Bihan, M Widya, RLM Van Montfort, K Jones, ... Angewandte Chemie 129 (13), 3590-3594, 2017 | 71 | 2017 |
| Discovery of a chemical probe bisamide (CCT251236): an orally bioavailable efficacious pirin ligand from a heat shock transcription factor 1 (HSF1) phenotypic screen MD Cheeseman, NEA Chessum, CS Rye, AE Pasqua, MJ Tucker, ... Journal of medicinal chemistry 60 (1), 180-201, 2017 | 54 | 2017 |
| Kinetic optimization of lysine-targeting covalent inhibitors of HSP72 J Pettinger, M Carter, K Jones, MD Cheeseman Journal of Medicinal Chemistry 62 (24), 11383-11398, 2019 | 50 | 2019 |
| Exploiting protein conformational change to optimize adenosine-derived inhibitors of HSP70 MD Cheeseman, IM Westwood, O Barbeau, M Rowlands, S Dobson, ... Journal of Medicinal Chemistry 59 (10), 4625-4636, 2016 | 36 | 2016 |
| An efficient asymmetric synthesis of grenadamide R Green, M Cheeseman, S Duffill, A Merritt, SD Bull Tetrahedron letters 46 (46), 7931-7934, 2005 | 34 | 2005 |
| An efficient synthesis of semiplenamide C IR Davies, M Cheeseman, DG Niyadurupola, SD Bull Tetrahedron letters 46 (33), 5547-5549, 2005 | 32 | 2005 |
| N–N Bond-Forming Cyclization for the One-Pot Synthesis of N-Aryl[3,4-d]pyrazolopyrimidines LE Evans, MD Cheeseman, K Jones Organic letters 14 (13), 3546-3549, 2012 | 31 | 2012 |
| A temporary stereocentre approach for the asymmetric synthesis of chiral cyclopropane-carboxaldehydes M Cheeseman, IR Davies, P Axe, AL Johnson, SD Bull Organic & Biomolecular Chemistry 7 (17), 3537-3548, 2009 | 28 | 2009 |
| A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms AM Jones, IM Westwood, JD Osborne, TP Matthews, MD Cheeseman, ... Scientific reports 6 (1), 34701, 2016 | 27 | 2016 |
| Investigating apoptozole as a chemical probe for HSP70 inhibition LE Evans, MD Cheeseman, N Yahya, K Jones PLoS One 10 (10), e0140006, 2015 | 27 | 2015 |
| Efficient asymmetric synthesis of chiral hydroxy-γ-butyrolactones IR Davies, M Cheeseman, R Green, MF Mahon, A Merritt, SD Bull Organic Letters 11 (13), 2896-2899, 2009 | 24 | 2009 |
| Synthesis of (+)-DGDP and (−)-7-epialexine TJC áO'Riordan Organic & Biomolecular Chemistry 6 (21), 3896-3898, 2008 | 24 | 2008 |
| Stereoselective synthesis of (E)-trisubstituted α, β-unsaturated amides and acids FJP Feuillet, M Cheeseman, MF Mahon, SD Bull Organic & Biomolecular Chemistry 3 (16), 2976-2989, 2005 | 24 | 2005 |
| Discovery of 4, 6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9 CS Rye, NEA Chessum, S Lamont, KG Pike, P Faulder, J Demeritt, ... Medchemcomm 7 (8), 1580-1586, 2016 | 23 | 2016 |
| Asymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocenters J Peed, I Periñán Domínguez, IR Davies, M Cheeseman, JE Taylor, ... Organic Letters 13 (14), 3592-3595, 2011 | 21 | 2011 |
| Privileged structures and polypharmacology within and between protein families J Meyers, NEA Chessum, S Ali, NY Mok, B Wilding, AE Pasqua, ... ACS Medicinal Chemistry Letters 9 (12), 1199-1204, 2018 | 19 | 2018 |
| Auf Lysin zielende, kovalente Inhibitoren J Pettinger, K Jones, MD Cheeseman Angewandte Chemie 129 (48), 15398-15408, 2017 | 15 | 2017 |
Paul WorkmanChief Executive & President, Institute of Cancer Research, LondonVerified email at icr.ac.uk