Articles with public access mandates - Nancy C HortonLearn more
Available somewhere: 26
Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation
CK Park, NC Horton
Biophysical reviews 11 (6), 927-994, 2019
Mandates: US National Science Foundation
The structure of SgrAI bound to DNA; recognition of an 8 base pair target
PW Dunten, EJ Little, MT Gregory, VM Manohar, M Dalton, D Hough, ...
Nucleic acids research 36 (16), 5405-5416, 2008
Mandates: US National Institutes of Health
Structural analysis of activated SgrAI–DNA oligomers using ion mobility mass spectrometry
X Ma, S Shah, M Zhou, CK Park, VH Wysocki, NC Horton
Biochemistry 52 (25), 4373-4381, 2013
Mandates: US National Institutes of Health
DNA binding and cleavage by the human parvovirus B19 NS1 nuclease domain
JL Sanchez, Z Romero, A Quinones, KR Torgeson, NC Horton
Biochemistry 55 (47), 6577-6593, 2016
Mandates: US National Science Foundation, US National Institutes of Health
Allosteric regulation of DNA cleavage and sequence-specificity through run-on oligomerization
D Lyumkis, H Talley, A Stewart, S Shah, CK Park, F Tama, CS Potter, ...
Structure 21 (10), 1848-1858, 2013
Mandates: US National Institutes of Health
Early interrogation and recognition of DNA sequence by indirect readout
EJ Little, AC Babic, NC Horton
Structure 16 (12), 1828-1837, 2008
Mandates: US National Institutes of Health
Activation of DNA cleavage by oligomerization of DNA-bound SgrAI
CK Park, AP Stiteler, S Shah, MI Ghare, J Bitinaite, NC Horton
Biochemistry 49 (41), 8818-8830, 2010
Mandates: US National Institutes of Health, Howard Hughes Medical Institute
Domain swapping in allosteric modulation of DNA specificity
CK Park, HK Joshi, A Agrawal, MI Ghare, EJ Little, PW Dunten, J Bitinaite, ...
PLoS biology 8 (12), e1000554, 2010
Mandates: US National Institutes of Health, Howard Hughes Medical Institute
Endonuclease activity inhibition of the NS1 protein of parvovirus B19 as a novel target for antiviral drug development
P Xu, SS Ganaie, X Wang, Z Wang, S Kleiboeker, NC Horton, RF Heier, ...
Antimicrobial agents and chemotherapy 63 (3), 10.1128/aac. 01879-18, 2019
Mandates: US National Institutes of Health
Influenza AM2 channel oligomerization is sensitive to its chemical environment
JA Townsend, HM Sanders, AD Rolland, CK Park, NC Horton, JS Prell, ...
Analytical chemistry 93 (48), 16273-16281, 2021
Mandates: US National Science Foundation, US National Institutes of Health
New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA
EJ Little, PW Dunten, J Bitinaite, NC Horton
Acta Crystallographica Section D: Biological Crystallography 67 (1), 67-74, 2011
Mandates: US National Institutes of Health
Mechanism of filamentation-induced allosteric activation of the SgrAI endonuclease
S Polley, D Lyumkis, NC Horton
Structure 27 (10), 1497-1507. e3, 2019
Mandates: US National Science Foundation, US National Institutes of Health, Wellcome …
Novel insights into filament-forming enzymes
CK Park, NC Horton
Nature Reviews Molecular Cell Biology 21 (1), 1-2, 2020
Mandates: US National Science Foundation
Probing the run-on oligomer of activated SgrAI bound to DNA
S Shah, J Sanchez, A Stewart, MM Piperakis, R Cosstick, C Nichols, ...
PLoS One 10 (4), e0124783, 2015
Mandates: US National Institutes of Health
DNA distortion and specificity in a sequence-specific endonuclease
AC Babic, EJ Little, VM Manohar, J Bitinaite, NC Horton
Journal of molecular biology 383 (1), 186-204, 2008
Mandates: US National Institutes of Health
The need for speed: run-on oligomer filament formation provides maximum speed with maximum sequestration of activity
CJ Barahona, LE Basantes, KJ Tompkins, DM Heitman, BI Chukwu, ...
Journal of Virology 93 (5), 10.1128/jvi. 01647-18, 2019
Mandates: US National Science Foundation, US National Institutes of Health
The run-on oligomer filament enzyme mechanism of SgrAI: Part 2. Kinetic modeling of the full DNA cleavage pathway
CK Park, JL Sanchez, C Barahona, LE Basantes, J Sanchez, ...
Journal of Biological Chemistry 293 (38), 14599-14615, 2018
Mandates: US National Science Foundation, US National Institutes of Health
The run-on oligomer filament enzyme mechanism of SgrAI: Part 1. Assembly kinetics of the run-on oligomer filament.
NCH CK Park, JL Sanchez, C, Barahona, LE Basantes, J Sanchez, C Hernandez
J Biol Chem 293, 14585-14598, 2018
Mandates: US National Science Foundation, US National Institutes of Health
High-resolution structure of the nuclease domain of the human parvovirus B19 main replication protein NS1
JL Sanchez, N Ghadirian, NC Horton
Journal of Virology 96 (9), e02164-21, 2022
Mandates: US Department of Energy, US National Institutes of Health
Pretransition state and apo structures of the filament-forming enzyme SgrAI elucidate mechanisms of activation and substrate specificity
Z Shan, N Ghadirian, D Lyumkis, NC Horton
Journal of Biological Chemistry 298 (4), 2022
Mandates: US National Science Foundation, US Department of Energy, US National …
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