| Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth Q Pan, Y Chanthery, WC Liang, S Stawicki, J Mak, N Rathore, RK Tong, ... Cancer cell 11 (1), 53-67, 2007 | 686 | 2007 |
| Blocking neuropilin-2 function inhibits tumor cell metastasis M Caunt, J Mak, WC Liang, S Stawicki, Q Pan, RK Tong, J Kowalski, C Ho, ... Cancer cell 13 (4), 331-342, 2008 | 418 | 2008 |
| Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates YJ Yu, JK Atwal, Y Zhang, RK Tong, KR Wildsmith, C Tan, N Bien-Ly, ... Science translational medicine 6 (261), 261ra154-261ra154, 2014 | 376 | 2014 |
| Effector-attenuating substitutions that maintain antibody stability and reduce toxicity in mice M Lo, HS Kim, RK Tong, TW Bainbridge, JM Vernes, Y Zhang, YL Lin, ... Journal of Biological Chemistry 292 (9), 3900-3908, 2017 | 281 | 2017 |
| Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting Q Pan, Y Chathery, Y Wu, N Rathore, RK Tong, F Peale, A Bagri, ... Journal of Biological Chemistry 282 (33), 24049-24056, 2007 | 267 | 2007 |
| Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier JA Couch, YJ Yu, Y Zhang, JM Tarrant, RN Fuji, WJ Meilandt, H Solanoy, ... Science translational medicine 5 (183), 183ra57-183ra57, 2013 | 265 | 2013 |
| Discovery of novel blood-brain barrier targets to enhance brain uptake of therapeutic antibodies YJY Zuchero, X Chen, N Bien-Ly, D Bumbaca, RK Tong, X Gao, S Zhang, ... Neuron 89 (1), 70-82, 2016 | 260 | 2016 |
| CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo FL Bos, M Caunt, J Peterson-Maduro, L Planas-Paz, J Kowalski, ... Circulation research 109 (5), 486-491, 2011 | 248 | 2011 |
| Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys MS Kariolis, RC Wells, JA Getz, W Kwan, CS Mahon, R Tong, DJ Kim, ... Science translational medicine 12 (545), eaay1359, 2020 | 234 | 2020 |
| Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B AW Koch, T Mathivet, B Larrivée, RK Tong, J Kowalski, L Pibouin-Fragner, ... Developmental cell 20 (1), 33-46, 2011 | 230 | 2011 |
| Sustained brown fat stimulation and insulin sensitization by a humanized bispecific antibody agonist for fibroblast growth factor receptor 1/βKlotho complex G Kolumam, MZ Chen, R Tong, J Zavala-Solorio, L Kates, N van Bruggen, ... EBioMedicine 2 (7), 730-743, 2015 | 114 | 2015 |
| Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2 A Jaworski, I Tom, RK Tong, HK Gildea, AW Koch, LC Gonzalez, ... Science 350 (6263), 961-965, 2015 | 105 | 2015 |
| Molecular understanding of USP7 substrate recognition and C-terminal activation L Rougé, TW Bainbridge, M Kwok, R Tong, P Di Lello, IE Wertz, T Maurer, ... Structure 24 (8), 1335-1345, 2016 | 97 | 2016 |
| The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization F Zhang, C Prahst, T Mathivet, L Pibouin-Fragner, J Zhang, G Genet, ... Nature communications 7 (1), 13517, 2016 | 54 | 2016 |
| MR angiogenesis imaging with Robo4-vs. αVβ3-targeted nanoparticles in a B16/F10 mouse melanoma model KS Boles, AH Schmieder, AW Koch, RAD Carano, Y Wu, SD Caruthers, ... The FASEB Journal 24 (11), 4262, 2010 | 47 | 2010 |
| Antiparallel conformation of knob and hole aglycosylated half-antibody homodimers is mediated by a CH2–CH3 hydrophobic interaction JM Elliott, M Ultsch, J Lee, R Tong, K Takeda, C Spiess, C Eigenbrot, ... Journal of molecular biology 426 (9), 1947-1957, 2014 | 44 | 2014 |
| Pharmacokinetic and pharmacodynamic analysis of circulating biomarkers of anti-NRP1, a novel antiangiogenesis agent, in two phase I trials in patients with advanced solid tumors Y Xin, J Li, J Wu, R Kinard, CD Weekes, A Patnaik, P LoRusso, ... Clinical Cancer Research 18 (21), 6040-6048, 2012 | 44 | 2012 |
| Prospective design of anti‐transferrin receptor bispecific antibodies for optimal delivery into the human brain JS Kanodia, K Gadkar, D Bumbaca, Y Zhang, RK Tong, W Luk, K Hoyte, ... CPT: pharmacometrics & systems pharmacology 5 (5), 283-291, 2016 | 41 | 2016 |
| CD98hc is a target for brain delivery of biotherapeutics KS Chew, RC Wells, A Moshkforoush, D Chan, KJ Lechtenberg, HL Tran, ... nature communications 14 (1), 5053, 2023 | 18 | 2023 |
| Targeting transferrin receptor to transport antisense oligonucleotides across the blood-brain barrier SJ Barker, MB Thayer, C Kim, D Tatarakis, M Simon, RL Dial, L Nilewski, ... BioRxiv, 2023.04. 25.538145, 2023 | 10 | 2023 |
