| Cancer-associated PIK3CA mutations in overgrowth disorders RR Madsen, B Vanhaesebroeck, RK Semple Trends in molecular medicine 24 (10), 856-870, 2018 | 243 | 2018 |
| PI3K in stemness regulation: from development to cancer RR Madsen Biochemical Society Transactions 48 (1), 301-315, 2020 | 59 | 2020 |
| Cracking the context-specific PI3K signaling code RR Madsen, B Vanhaesebroeck Science Signaling 13 (613), eaay2940, 2020 | 57 | 2020 |
| mTORC1 activity is supported by spatial association with focal adhesions Y Rabanal-Ruiz, A Byron, A Wirth, R Madsen, L Sedlackova, G Hewitt, ... Journal of Cell Biology 220 (5), 2021 | 53 | 2021 |
| Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner RR Madsen, RG Knox, W Pearce, S Lopez, B Mahler-Araujo, ... Proceedings of the National Academy of Sciences 116 (17), 8380-8389, 2019 | 52 | 2019 |
| Epigenetic regulation of vascular smooth muscle cells by histone H3 lysine 9 dimethylation attenuates target gene-induction by inflammatory signaling JL Harman, L Dobnikar, J Chappell, BG Stokell, A Dalby, K Foote, ... Arteriosclerosis, thrombosis, and vascular biology 39 (11), 2289-2302, 2019 | 38 | 2019 |
| A small-molecule PI3Kα activator for cardioprotection and neuroregeneration GQ Gong, B Bilanges, B Allsop, GR Masson, V Roberton, T Askwith, ... Nature 618 (7963), 159-168, 2023 | 36 | 2023 |
| Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor … JL Tarry-Adkins, DS Fernandez-Twinn, R Madsen, JH Chen, A Carpenter, ... Endocrinology 156 (10), 3528-3537, 2015 | 31 | 2015 |
| Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype RR Madsen, EC Erickson, OM Rueda, X Robin, C Caldas, A Toker, ... PLoS Genetics 17 (11), e1009876, 2021 | 16 | 2021 |
| Scientific impact and the quest for visibility RR Madsen The FEBS journal 286 (20), 3968-3974, 2019 | 13 | 2019 |
| PIK3CA-related overgrowth: silver bullets from the cancer arsenal? RR Madsen, RK Semple Trends in Molecular Medicine 28 (4), 255-257, 2022 | 11 | 2022 |
| Precision targeting of mutant PI3Kα in cancer by selective degradation B Vanhaesebroeck, JE Burke, RR Madsen Cancer discovery 12 (1), 20-22, 2022 | 11 | 2022 |
| Perspective: potential impact and therapeutic implications of oncogenic PI3K activation on chromosomal instability B Vanhaesebroeck, B Bilanges, RR Madsen, KL Dale, E Lau, ... Biomolecules 9 (8), 331, 2019 | 11 | 2019 |
| NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells RR Madsen, J Longden, RG Knox, X Robin, F Völlmy, KG Macleod, ... Disease models & mechanisms 14 (3), dmm048298, 2021 | 6 | 2021 |
| Luminescent peptide tagging enables efficient screening for CRISPR-mediated knock-in in human induced pluripotent stem cells RR Madsen, RK Semple Wellcome open research 4, 2019 | 6 | 2019 |
| Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation EC Erickson, I You, G Perry, A Dugourd, KA Donovan, C Crafter, ... Science signaling 17 (825), eadf2670, 2024 | 3 | 2024 |
| PI3K signaling through a biochemical systems lens RR Madsen, A Toker Journal of Biological Chemistry 299 (10), 2023 | 3 | 2023 |
| Funders must mandate and reward open research records. R Madsen Nature 586 (7828), 200-200, 2020 | 3 | 2020 |
| Investigation of genetic PIK3CA activation in genome-edited human pluripotent stem cells RR Madsen | 1 | 2019 |
| First person–Ralitsa Madsen R Madsen Disease Models & Mechanisms 14 (3), 2021 | | 2021 |
