| Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages X Deng, M Hackbart, RC Mettelman, A O’Brien, AM Mielech, G Yi, CC Kao, ... Proceedings of the National Academy of Sciences 114 (21), E4251-E4260, 2017 | 394 | 2017 |
| Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors M Hackbart, X Deng, SC Baker Proceedings of the National Academy of Sciences 117 (14), 8094-8103, 2020 | 300 | 2020 |
| Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir Y Hu, EM Lewandowski, H Tan, X Zhang, RT Morgan, X Zhang, ... ACS Central Science 9 (8), 1658-1669, 2023 | 179 | 2023 |
| An “Old” protein with a new story: Coronavirus endoribonuclease is important for evading host antiviral defenses X Deng, SC Baker Virology 517, 157-163, 2018 | 163 | 2018 |
| Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors A Kilianski, AM Mielech, X Deng, SC Baker Journal of virology 87 (21), 11955-11962, 2013 | 153 | 2013 |
| Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus YM Báez-Santos, AM Mielech, X Deng, S Baker, AD Mesecar Journal of virology 88 (21), 12511-12527, 2014 | 150 | 2014 |
| Coronavirus endoribonuclease activity in porcine epidemic diarrhea virus suppresses type I and type III interferon responses X Deng, A van Geelen, AC Buckley, A O’Brien, A Pillatzki, KM Lager, ... Journal of virology 93 (8), 10.1128/jvi. 02000-18, 2019 | 126 | 2019 |
| Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity Z Zhu, Z Shi, W Yan, J Wei, D Shao, X Deng, S Wang, B Li, G Tong, Z Ma PloS one 8 (2), e55920, 2013 | 118 | 2013 |
| Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance X Deng, SE StJohn, HL Osswald, A O'Brien, BS Banach, K Sleeman, ... Journal of Virology 88 (20), 11886-11898, 2014 | 105 | 2014 |
| Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model Z Shi, J Wei, X Deng, S Li, Y Qiu, D Shao, B Li, K Zhang, F Xue, X Wang, ... Virology journal 11, 1-10, 2014 | 82 | 2014 |
| Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis AM Mielech, X Deng, Y Chen, E Kindler, DL Wheeler, AD Mesecar, ... Journal of virology 89 (9), 4907-4917, 2015 | 73 | 2015 |
| The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities X Deng, X Li, Y Shen, Y Qiu, Z Shi, D Shao, Y Jin, H Chen, C Ding, L Li, ... Virology journal 7, 1-11, 2010 | 68 | 2010 |
| Stabilization of p53 in influenza A virus-infected cells is associated with compromised MDM2-mediated ubiquitination of p53 X Wang, X Deng, W Yan, Z Zhu, Y Shen, Y Qiu, Z Shi, D Shao, J Wei, ... Journal of Biological Chemistry 287 (22), 18366-18375, 2012 | 53 | 2012 |
| Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection W Yan, J Wei, X Deng, Z Shi, Z Zhu, D Shao, B Li, S Wang, G Tong, Z Ma BMC medical genomics 8, 1-10, 2015 | 44 | 2015 |
| Coronavirus endoribonuclease and deubiquitinating interferon antagonists differentially modulate the host response during replication in macrophages A Volk, M Hackbart, X Deng, Y Cruz-Pulido, A O’Brien, SC Baker Journal of virology 94 (11), 10.1128/jvi. 00178-20, 2020 | 39 | 2020 |
| Analysis of coronavirus temperature-sensitive mutants reveals an interplay between the macrodomain and papain-like protease impacting replication and pathogenesis X Deng, RC Mettelman, A O’Brien, JA Thompson, TE O’Brien, SC Baker Journal of virology 93 (12), 10.1128/jvi. 02140-18, 2019 | 37 | 2019 |
| Structure-guided mutagenesis alters deubiquitinating activity and attenuates pathogenesis of a murine coronavirus X Deng, Y Chen, AM Mielech, M Hackbart, KR Kesely, RC Mettelman, ... Journal of virology 94 (11), 10.1128/jvi. 01734-19, 2020 | 31 | 2020 |
| Inactivating three interferon antagonists attenuates pathogenesis of an enteric coronavirus X Deng, AC Buckley, A Pillatzki, KM Lager, KS Faaberg, SC Baker Journal of virology 94 (17), 10.1128/jvi. 00565-20, 2020 | 26 | 2020 |
| Characterization of nonstructural protein 3 of a neurovirulent Japanese encephalitis virus strain isolated from a pig X Deng, Z Shi, S Li, X Wang, Y Qiu, D Shao, J Wei, G Tong, Z Ma Virology Journal 8, 1-10, 2011 | 22 | 2011 |
| Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model B Tan, X Zhang, A Ansari, P Jadhav, H Tan, K Li, A Chopra, A Ford, X Chi, ... Science 383 (6690), 1434-1440, 2024 | 21 | 2024 |
Susan C. BakerProfessor of Microbiology and Immunology, Loyola University ChicagoVerified email at luc.edu