| Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies NP Hoyle, LM Castelli, SG Campbell, LEA Holmes, MP Ashe The Journal of cell biology 179 (1), 65-74, 2007 | 279 | 2007 |
| Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS A Varcianna, MA Myszczynska, LM Castelli, B O'Neill, Y Kim, J Talbot, ... EBioMedicine 40, 626-635, 2019 | 189 | 2019 |
| SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits GM Hautbergue, LM Castelli, L Ferraiuolo, A Sanchez-Martinez, ... Nature communications 8 (1), 16063, 2017 | 144 | 2017 |
| Identification and functional characterization of effectors in expressed sequence tags from various life cycle stages of the potato cyst nematode Globodera pallida JT Jones, A Kumar, LA Pylypenko, A Thirugnanasambandam, L Castelli, ... Molecular Plant Pathology 10 (6), 815-828, 2009 | 134 | 2009 |
| Mapping QTLs for resistance to the cyst nematode Globodera pallida derived from the wild potato species Solanum vernei G Bryan, K McLean, J Bradshaw, W De Jong, M Phillips, L Castelli, ... Theoretical and Applied Genetics 105, 68-77, 2002 | 134 | 2002 |
| Global mRNA selection mechanisms for translation initiation J Costello, LM Castelli, W Rowe, CJ Kershaw, D Talavera, ... Genome biology 16, 1-21, 2015 | 116 | 2015 |
| Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis SP Allen, B Hall, LM Castelli, L Francis, R Woof, AP Siskos, E Kouloura, ... Brain 142 (3), 586-605, 2019 | 112 | 2019 |
| Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up … LM Castelli, J Lui, SG Campbell, W Rowe, LAH Zeef, LEA Holmes, ... Molecular biology of the cell 22 (18), 3379-3393, 2011 | 103 | 2011 |
| Granules harboring translationally active mRNAs provide a platform for P-body formation following stress J Lui, LM Castelli, M Pizzinga, CE Simpson, NP Hoyle, KL Bailey, ... Cell reports 9 (3), 944-954, 2014 | 71 | 2014 |
| Mutations in the glycosyltransferase domain of GLT8D1 are associated with familial amyotrophic lateral sclerosis J Cooper-Knock, T Moll, T Ramesh, L Castelli, A Beer, H Robins, I Fox, ... Cell reports 26 (9), 2298-2306. e5, 2019 | 70 | 2019 |
| Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features MP Shaw, A Higginbottom, A McGown, LM Castelli, E James, ... Acta neuropathologica communications 6, 1-16, 2018 | 67 | 2018 |
| Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins AG Cridge, LM Castelli, JB Smirnova, JN Selley, W Rowe, SJ Hubbard, ... Nucleic acids research 38 (22), 8039-8050, 2010 | 65 | 2010 |
| Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p CJ Kershaw, JL Costello, D Talavera, W Rowe, LM Castelli, PFG Sims, ... Scientific reports 5 (1), 15518, 2015 | 55 | 2015 |
| Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease N Gatto, C Dos Santos Souza, AC Shaw, SM Bell, MA Myszczynska, ... Aging Cell 20 (1), e13281, 2021 | 49 | 2021 |
| The 4E-BP Caf20p mediates both eIF4E-dependent and independent repression of translation LM Castelli, D Talavera, CJ Kershaw, SS Mohammad-Qureshi, ... PLoS genetics 11 (5), e1005233, 2015 | 49 | 2015 |
| New sources of resistance to the potato cyst nematodes Globodera pallida and G. rostochiensis in the Commonwealth Potato Collection L Castelli, G Ramsay, G Bryan, SJ Neilson, MS Phillips Euphytica 129, 377-386, 2003 | 45 | 2003 |
| The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response CJ Kershaw, JL Costello, LM Castelli, D Talavera, W Rowe, PFG Sims, ... PLoS genetics 11 (1), e1004903, 2015 | 43 | 2015 |
| Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses JL Costello, CJ Kershaw, LM Castelli, D Talavera, W Rowe, PFG Sims, ... Genome biology 18, 1-18, 2017 | 40 | 2017 |
| Puf3p induces translational repression of genes linked to oxidative stress W Rowe, CJ Kershaw, LM Castelli, JL Costello, MP Ashe, CM Grant, ... Nucleic acids research 42 (2), 1026-1041, 2013 | 40 | 2013 |
| Site specific modification of adeno-associated virus enables both fluorescent imaging of viral particles and characterization of the capsid interactome JS Chandran, PS Sharp, E Karyka, JMC Aves-Cruzeiro, I Coldicott, ... Scientific reports 7 (1), 14766, 2017 | 37 | 2017 |