Direct conversion of human fibroblasts to dopaminergic neurons U Pfisterer, A Kirkeby, O Torper, J Wood, J Nelander, A Dufour, ... Proceedings of the National Academy of Sciences 108 (25), 10343-10348, 2011 | 906 | 2011 |
Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions A Kirkeby, S Grealish, DA Wolf, J Nelander, J Wood, M Lundblad, ... Cell reports 1 (6), 703-714, 2012 | 758 | 2012 |
Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson’s disease S Grealish, E Diguet, A Kirkeby, B Mattsson, A Heuer, Y Bramoulle, ... Cell stem cell 15 (5), 653-665, 2014 | 479 | 2014 |
Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson’s Disease A Kirkeby, S Nolbrant, K Tiklova, A Heuer, T Kee, Nigel Cardoso, ... Cell Stem Cell, 2016 | 287 | 2016 |
Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation S Nolbrant, A Heuer, M Parmar, A Kirkeby Nature protocols 12 (9), 1962-1979, 2017 | 231 | 2017 |
Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient P Rifes, M Isaksson, GS Rathore, P Aldrin-Kirk, OK Møller, G Barzaghi, ... Nature biotechnology 38 (11), 1265-1273, 2020 | 150 | 2020 |
Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages N Kee, N Volakakis, A Kirkeby, L Dahl, H Storvall, S Nolbrant, L Lahti, ... Cell Stem Cell, 2016 | 148 | 2016 |
Sense-antisense lncRNA pair encoded by locus 6p22. 3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory axis T Mondal, PK Juvvuna, A Kirkeby, S Mitra, ST Kosalai, L Traxler, ... Cancer cell 33 (3), 417-434. e7, 2018 | 135 | 2018 |
Strategies for bringing stem cell-derived dopamine neurons to the clinic: a European approach (STEM-PD) A Kirkeby, M Parmar, RA Barker Progress in brain research 230, 165-190, 2017 | 102 | 2017 |
Monosynaptic tracing using modified rabies virus reveals early and extensive circuit integration of human embryonic stem cell-derived neurons S Grealish, A Heuer, T Cardoso, A Kirkeby, M Jönsson, J Johansson, ... Stem cell reports 4 (6), 975-983, 2015 | 101 | 2015 |
Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease K Tiklová, S Nolbrant, A Fiorenzano, ÅK Björklund, Y Sharma, A Heuer, ... Nature communications 11 (1), 2434, 2020 | 95 | 2020 |
Are stem cell-based therapies for Parkinson’s disease ready for the clinic in 2016? RA Barker, M Parmar, A Kirkeby, A Björklund, L Thompson, P Brundin Journal of Parkinson's disease 6 (1), 57-63, 2016 | 90 | 2016 |
Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen–glucose deprivation (OGD) and NMDA excitotoxicity … M Montero, FR Poulsen, J Noraberg, A Kirkeby, J van Beek, M Leist, ... Experimental Neurology 204 (1), 106-117, 2007 | 87 | 2007 |
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy M Leist, S Bremer, P Brundin, J Hescheler, A Kirkeby, KH Krause, ... | 84 | 2008 |
Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor A Kirkeby, J van Beek, J Nielsen, M Leist, L Helboe Journal of neuroscience methods 164 (1), 50-58, 2007 | 80 | 2007 |
High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO) A Kirkeby, L Torup, L Bochsen, M Kjalke, K Abel, K Theilgaard-Monch, ... Thrombosis and haemostasis 99 (04), 720-728, 2008 | 76 | 2008 |
Generating regionalized neuronal cells from pluripotency, a step-by-step protocol A Kirkeby, J Nelander, M Parmar Frontiers in cellular neuroscience 6, 64, 2013 | 65 | 2013 |
Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits PA Lapchak, A Kirkeby, JA Zivin, TN Sager Brain research 1238, 208-214, 2008 | 62 | 2008 |
Target‐specific forebrain projections and appropriate synaptic inputs of hESC‐derived dopamine neurons grafted to the midbrain of Parkinsonian rats T Cardoso, AF Adler, B Mattsson, DB Hoban, S Nolbrant, JN Wahlestedt, ... Journal of Comparative Neurology 526 (13), 2133-2146, 2018 | 59 | 2018 |
IAP-based cell sorting results in homogeneous transplantable dopaminergic precursor cells derived from human pluripotent stem cells D Lehnen, S Barral, T Cardoso, S Grealish, A Heuer, A Smiyakin, ... Stem Cell Reports 9 (4), 1207-1220, 2017 | 57 | 2017 |