Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients G Schwank, BK Koo, V Sasselli, JF Dekkers, I Heo, T Demircan, N Sasaki, ... Cell stem cell 13 (6), 653-658, 2013 | 1634 | 2013 |
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration M Huch, C Dorrell, SF Boj, JH Van Es, VSW Li, M Van De Wetering, ... Nature 494 (7436), 247-250, 2013 | 1627 | 2013 |
Long-term culture of genome-stable bipotent stem cells from adult human liver M Huch, H Gehart, R Van Boxtel, K Hamer, F Blokzijl, MMA Verstegen, ... Cell 160 (1), 299-312, 2015 | 1516 | 2015 |
Single-cell messenger RNA sequencing reveals rare intestinal cell types D Grün, A Lyubimova, L Kester, K Wiebrands, O Basak, N Sasaki, ... Nature 525 (7568), 251-255, 2015 | 1295 | 2015 |
Tissue-specific mutation accumulation in human adult stem cells during life F Blokzijl, J De Ligt, M Jager, V Sasselli, S Roerink, N Sasaki, M Huch, ... Nature 538 (7624), 260-264, 2016 | 906 | 2016 |
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage JH Van Es, T Sato, M Van De Wetering, A Lyubimova, AN Yee Nee, ... Nature cell biology 14 (10), 1099-1104, 2012 | 835 | 2012 |
Intra-tumour diversification in colorectal cancer at the single-cell level SF Roerink, N Sasaki, H Lee-Six, MD Young, LB Alexandrov, S Behjati, ... Nature 556 (7702), 457-462, 2018 | 490 | 2018 |
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer J Drost, R Van Boxtel, F Blokzijl, T Mizutani, N Sasaki, V Sasselli, J de Ligt, ... Science 358 (6360), 234-238, 2017 | 429 | 2017 |
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis N Nakamoto, N Sasaki, R Aoki, K Miyamoto, W Suda, T Teratani, T Suzuki, ... Nature microbiology 4 (3), 492-503, 2019 | 344 | 2019 |
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon N Sasaki, N Sachs, K Wiebrands, SIJ Ellenbroek, A Fumagalli, ... Proceedings of the National Academy of Sciences 113 (37), E5399-E5407, 2016 | 343 | 2016 |
Somatic inflammatory gene mutations in human ulcerative colitis epithelium K Nanki, M Fujii, M Shimokawa, M Matano, S Nishikori, S Date, A Takano, ... Nature 577 (7789), 254-259, 2020 | 251 | 2020 |
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids ACF Bolhaqueiro, B Ponsioen, B Bakker, SJ Klaasen, E Kucukkose, ... Nature genetics 51 (5), 824-834, 2019 | 202 | 2019 |
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions T Sasamura, N Sasaki, F Miyashita, S Nakao, HO Ishikawa, M Ito, ... Oxford University Press for The Company of Biologists Limited 130 (20), 4785 …, 2003 | 198 | 2003 |
Automated brightfield morphometry of 3D organoid populations by OrganoSeg MA Borten, SS Bajikar, N Sasaki, H Clevers, KA Janes Scientific reports 8 (1), 5319, 2018 | 118 | 2018 |
Defining the identity and dynamics of adult gastric isthmus stem cells S Han, J Fink, DJ Jörg, E Lee, MK Yum, L Chatzeli, SR Merker, ... Cell stem cell 25 (3), 342-356. e7, 2019 | 117 | 2019 |
Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome AS Cornier, K Staehling-Hampton, KM Delventhal, Y Saga, JF Caubet, ... The American Journal of Human Genetics 82 (6), 1334-1341, 2008 | 108 | 2008 |
The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite M Morimoto, N Sasaki, M Oginuma, M Kiso, K Igarashi, K Aizaki, J Kanno, ... Oxford University Press for The Company of Biologists Limited 134 (8), 1561-1569, 2007 | 108 | 2007 |
The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila T Sasamura, HO Ishikawa, N Sasaki, S Higashi, M Kanai, S Nakao, ... Oxford University Press for The Company of Biologists Limited 134 (7), 1347-1356, 2007 | 96 | 2007 |
Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion JH Van Es, K Wiebrands, C López-Iglesias, M Van De Wetering, ... Proceedings of the National Academy of Sciences 116 (52), 26599-26605, 2019 | 87 | 2019 |
Generation of BAC transgenic epithelial organoids G Schwank, A Andersson-Rolf, BK Koo, N Sasaki, H Clevers PloS one 8 (10), e76871, 2013 | 84 | 2013 |