| Quaternary ammonium compounds: an antimicrobial mainstay and platform for innovation to address bacterial resistance MC Jennings, KPC Minbiole, WM Wuest ACS infectious diseases 1 (7), 288-303, 2015 | 628 | 2015 |
| Natural products as platforms to overcome antibiotic resistance SE Rossiter, MH Fletcher, WM Wuest Chemical reviews 117 (19), 12415-12474, 2017 | 555 | 2017 |
| A new class of synthetic retinoid antibiotics effective against bacterial persisters W Kim, W Zhu, GL Hendricks, D Van Tyne, AD Steele, CE Keohane, ... Nature 556 (7699), 103-107, 2018 | 364 | 2018 |
| Biofilm‐eradicating properties of quaternary ammonium amphiphiles: simple mimics of antimicrobial peptides MC Jennings, LE Ator, TJ Paniak, KPC Minbiole, WM Wuest ChemBioChem 15 (15), 2211-2215, 2014 | 169 | 2014 |
| Are quaternary ammonium compounds, the workhorse disinfectants, effective against severe acute respiratory syndrome-coronavirus-2? CL Schrank, KPC Minbiole, WM Wuest ACS infectious diseases 6 (7), 1553-1557, 2020 | 145 | 2020 |
| A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus W Kim, G Zou, TPA Hari, IK Wilt, W Zhu, N Galle, HA Faizi, GL Hendricks, ... Proceedings of the National Academy of Sciences 116 (33), 16529-16534, 2019 | 138 | 2019 |
| The silent pandemic: Emergent antibiotic resistances following the global response to SARS-CoV-2 AR Mahoney, MM Safaee, WM Wuest, AL Furst Iscience 24 (4), 2021 | 116 | 2021 |
| From antimicrobial activity to mechanism of resistance: the multifaceted role of simple quaternary ammonium compounds in bacterial eradication KPC Minbiole, MC Jennings, LE Ator, JW Black, MC Grenier, JE LaDow, ... Tetrahedron 72 (25), 3559-3566, 2016 | 111 | 2016 |
| Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms P Le, E Kunold, R Macsics, K Rox, MC Jennings, I Ugur, M Reinecke, ... Nature chemistry 12 (2), 145-158, 2020 | 103 | 2020 |
| Evolution of multi-component anion relay chemistry (ARC): construction of architecturally complex natural and unnatural products AB Smith III, WM Wuest Chemical communications, 5883-5895, 2008 | 101 | 2008 |
| Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus MC Jennings, BA Buttaro, KPC Minbiole, WM Wuest ACS infectious diseases 1 (7), 304-309, 2015 | 96 | 2015 |
| Intramolecular hydroamination of aminoalkynes with silver-phenanthroline catalysts. JM Carney, PJ Donoghue, WM Wuest, O Wiest, P Helquist Organic letters 10 (17), 3903-3906, 2008 | 94 | 2008 |
| Targeting S. mutans biofilms: a perspective on preventing dental caries AM Scharnow, AE Solinski, WM Wuest Medchemcomm 10 (7), 1057-1067, 2019 | 89 | 2019 |
| Three siderophores from one bacterial enzymatic assembly line WM Wuest, ES Sattely, CT Walsh Journal of the American Chemical Society 131 (14), 5056-5057, 2009 | 80 | 2009 |
| Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase CE Keohane, AD Steele, C Fetzer, J Khowsathit, D Van Tyne, L Moynié, ... Journal of the American Chemical Society 140 (5), 1774-1782, 2018 | 76 | 2018 |
| More QACs, more questions: Recent advances in structure activity relationships and hurdles in understanding resistance mechanisms KR Morrison, RA Allen, KPC Minbiole, WM Wuest Tetrahedron letters 60 (37), 150935, 2019 | 65 | 2019 |
| Building a better quaternary ammonium compound (QAC): branched tetracationic antiseptic amphiphiles ME Forman, MC Jennings, WM Wuest, KPC Minbiole ChemMedChem 11 (13), 1401-1405, 2016 | 65 | 2016 |
| Analysis of the destabilization of bacterial membranes by quaternary ammonium compounds: a combined experimental and computational study S Alkhalifa, MC Jennings, D Granata, M Klein, WM Wuest, KPC Minbiole, ... ChemBioChem 21 (10), 1510-1516, 2020 | 61 | 2020 |
| The antimicrobial activity of mono-, bis-, tris-, and tetracationic amphiphiles derived from simple polyamine platforms TJ Paniak, MC Jennings, PC Shanahan, MD Joyce, CN Santiago, ... Bioorganic & Medicinal Chemistry Letters 24 (24), 5824-5828, 2014 | 60 | 2014 |
| TMEDA-derived biscationic amphiphiles: An economical preparation of potent antibacterial agents JW Black, MC Jennings, J Azarewicz, TJ Paniak, MC Grenier, WM Wuest, ... Bioorganic & medicinal chemistry letters 24 (1), 99-102, 2014 | 56 | 2014 |
Kevin MinbioleProfessor of Chemistry, Villanova UniversityVerified email at villanova.edu
