A practical synthesis of (+)-discodermolide and analogues: fragment union by complex aldol reactions I Paterson, J Gordon, K Gerlach, JP Scott, N Sereinig Journal of the American Chemical Society 123 (39), 9535-9544, 2001 | 290 | 2001 |
Highly chemoselective oxidation of 1, 5-diols to δ-lactones with TEMPO/BAIB TM Hansen, GJ Florence, P Lugo-Mas, J Chen, JN Abrams, CJ Forsyth Tetrahedron letters 44 (1), 57-59, 2003 | 216 | 2003 |
Total Synthesis of the Antimicrotubule Agent (+)‐Discodermolide Using Boron‐Mediated Aldol Reactions of Chiral Ketones I Paterson, GJ Florence, K Gerlach, JP Scott Angewandte Chemie 112 (2), 385-388, 2000 | 216 | 2000 |
Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 5: Linkage of Fragments C1-6 and C7-24 and Finale SJ Mickel, D Niederer, R Daeffler, A Osmani, E Kuesters, E Schmid, ... Organic process research & development 8 (1), 122-130, 2004 | 197 | 2004 |
Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 4: Preparation of Fragment C7-24 SJ Mickel, GH Sedelmeier, D Niederer, F Schuerch, M Seger, K Schreiner, ... Organic process research & development 8 (1), 113-121, 2004 | 130 | 2004 |
Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin GJ Florence, NM Gardner, I Paterson Natural product reports 25 (2), 342-375, 2008 | 126 | 2008 |
1, 6-asymmetric induction in boron-mediated aldol reactions: application to a practical total synthesis of (+)-discodermolide I Paterson, O Delgado, J Gordon, I Lyothier, JP Scott, N Sereinig Organic Letters 5 (1), 35-38, 2003 | 117 | 2003 |
Approaches to CNS drug delivery with a focus on transporter-mediated transcytosis R Abdul Razzak, GJ Florence, FJ Gunn-Moore International journal of molecular sciences 20 (12), 3108, 2019 | 94 | 2019 |
Synthesis of (+)-discodermolide and analogues by control of asymmetric induction in aldol reactions of γ-chiral (Z)-enals I Paterson, GJ Florence Tetrahedron Letters 41 (35), 6935-6939, 2000 | 79 | 2000 |
The development of a practical total synthesis of discodermolide, a promising microtubule‐stabilizing anticancer agent I Paterson, GJ Florence European Journal of Organic Chemistry 2003 (12), 2193-2208, 2003 | 75 | 2003 |
Stereocontrolled Total Synthesis of (−)‐Aurisides A and B I Paterson, GJ Florence, AC Heimann, AC Mackay Angewandte Chemie International Edition 44 (7), 1130-1133, 2005 | 73 | 2005 |
Total synthesis and stereochemical reassignment of (+)-dolastatin 19 I Paterson, AD Findlay, GJ Florence Organic Letters 8 (10), 2131-2134, 2006 | 60 | 2006 |
Discodermolide interferes with the binding of tau protein to microtubules S Kar, GJ Florence, I Paterson, LA Amos FEBS letters 539 (1-3), 34-36, 2003 | 60 | 2003 |
An internal thioester in a pathogen surface protein mediates covalent host binding M Walden, JM Edwards, AM Dziewulska, R Bergmann, G Saalbach, ... Elife 4, e06638, 2015 | 58 | 2015 |
Total Synthesis of (−)‐Reidispongiolide A, an Actin‐Targeting Marine Macrolide I Paterson, K Ashton, R Britton, G Cecere, G Chouraqui, GJ Florence, ... Angewandte Chemie International Edition 46 (32), 6167-6171, 2007 | 52 | 2007 |
Total Synthesis of (−)‐Reidispongiolide A, an Actin‐Targeting Macrolide Isolated from the Marine Sponge Reidispongia coerulea I Paterson, K Ashton, R Britton, G Cecere, G Chouraqui, GJ Florence, ... Chemistry–An Asian Journal 3 (2), 367-387, 2008 | 48 | 2008 |
The trypanosome alternative oxidase: a potential drug target? SK Menzies, LB Tulloch, GJ Florence, TK Smith Parasitology 145 (2), 175-183, 2018 | 46 | 2018 |
Direct and indirect approaches to identify drug modes of action LB Tulloch, SK Menzies, RP Coron, MD Roberts, GJ Florence, TK Smith Iubmb Life 70 (1), 9-22, 2018 | 40 | 2018 |
Total synthesis and stereochemical reassignment of (+)-dolastatin 19, a cytotoxic marine macrolide isolated from Dolabella auricularia I Paterson, AD Findlay, GJ Florence Tetrahedron 63 (26), 5806-5819, 2007 | 37 | 2007 |
A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel DA Dabydeen, GJ Florence, I Paterson, E Hamel Cancer chemotherapy and pharmacology 53, 397-403, 2004 | 31 | 2004 |