The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD J Sun, A Siroy, RK Lokareddy, A Speer, KS Doornbos, G Cingolani, ... Nature structural & molecular biology 22 (9), 672-678, 2015 | 138 | 2015 |
IpaB–IpgC interaction defines binding motif for type III secretion translocator M Lunelli, RK Lokareddy, A Zychlinsky, M Kolbe Proceedings of the National Academy of Sciences 106 (24), 9661-9666, 2009 | 130 | 2009 |
Nuclear pores promote lethal prostate cancer by increasing POM121-driven E2F1, MYC, and AR nuclear import V Rodriguez-Bravo, R Pippa, WM Song, M Carceles-Cordon, ... Cell 174 (5), 1200-1215. e20, 2018 | 121 | 2018 |
Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation RK Lokareddy, RS Sankhala, A Roy, PV Afonine, T Motwani, CM Teschke, ... Nature communications 8 (1), 14310, 2017 | 92 | 2017 |
Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion JA Horstmann, M Lunelli, H Cazzola, J Heidemann, C Kühne, P Steffen, ... Nature communications 11 (1), 2013, 2020 | 82 | 2020 |
A new cell secreting insulin SS Roy, M Mukherjee, S Bhattacharya, CN Mandal, LR Kumar, ... Endocrinology 144 (4), 1585-1593, 2003 | 66 | 2003 |
Structure-based screen identifies a potent small molecule inhibitor of Stat5a/b with therapeutic potential for prostate cancer and chronic myeloid leukemia Z Liao, L Gu, J Vergalli, SA Mariani, M De Dominici, RK Lokareddy, ... Molecular cancer therapeutics 14 (8), 1777-1793, 2015 | 52 | 2015 |
Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1 RS Sankhala, RK Lokareddy, S Begum, RA Pumroy, RE Gillilan, ... Nature Communications 8 (1), 979, 2017 | 48 | 2017 |
Combination of two separate binding domains defines stoichiometry between type III secretion system chaperone IpgC and translocator protein IpaB RK Lokareddy, M Lunelli, B Eilers, V Wolter, M Kolbe Journal of Biological Chemistry 285 (51), 39965-39975, 2010 | 48 | 2010 |
Distinctive properties of the nuclear localization signals of inner nuclear membrane proteins Heh1 and Heh2 RK Lokareddy, RA Hapsari, M van Rheenen, RA Pumroy, A Bhardwaj, ... Structure 23 (7), 1305-1316, 2015 | 46 | 2015 |
A viral scaffolding protein triggers portal ring oligomerization and incorporation during procapsid assembly T Motwani, RK Lokareddy, CA Dunbar, JR Cortines, MF Jarrold, ... Science Advances 3 (7), e1700423, 2017 | 40 | 2017 |
Architecture of the complex formed by large and small terminase subunits from bacteriophage P22 R McNulty, RK Lokareddy, A Roy, Y Yang, GC Lander, AJR Heck, ... Journal of molecular biology 427 (20), 3285-3299, 2015 | 37 | 2015 |
Recognition of the TDP-43 nuclear localization signal by importin α1/β SG Doll, H Meshkin, AJ Bryer, F Li, YH Ko, RK Lokareddy, RE Gillilan, ... Cell reports 39 (13), 2022 | 35 | 2022 |
Differential recognition of canonical NF-κB dimers by Importin α3 TJ Florio, RK Lokareddy, DP Yeggoni, RS Sankhala, CA Ott, RE Gillilan, ... Nature Communications 13 (1), 1207, 2022 | 32 | 2022 |
Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins A Kralt, NB Jagalur, V Van Den Boom, RK Lokareddy, A Steen, ... Molecular Biology of the Cell 26 (18), 3301-3312, 2015 | 32 | 2015 |
Divergent evolution of nuclear localization signal sequences in herpesvirus terminase subunits RS Sankhala, RK Lokareddy, G Cingolani Journal of Biological Chemistry 291 (21), 11420-11433, 2016 | 29 | 2016 |
Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms W Wu, RS Sankhala, TJ Florio, L Zhou, NLT Nguyen, RK Lokareddy, ... Scientific reports 7 (1), 11381, 2017 | 28 | 2017 |
The p53-induced factor Ei24 inhibits nuclear import through an importin β–binding–like domain KG Lieu, EH Shim, J Wang, RK Lokareddy, T Tao, G Cingolani, ... Journal of Cell Biology 205 (3), 301-312, 2014 | 26 | 2014 |
Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution NA Swanson, RK Lokareddy, F Li, CFD Hou, S Leptihn, M Pavlenok, ... Molecular cell 81 (15), 3145-3159. e7, 2021 | 25 | 2021 |
Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA G Cingolani, M McCauley, A Lobley, AJ Bryer, J Wesolowski, DL Greco, ... Nature communications 10 (1), 2747, 2019 | 25 | 2019 |