| Advanced glycosylation: chemistry, biology, and implications for diabetes and aging R Bucala, A Cerami Advances in pharmacology 23, 1-34, 1992 | 682 | 1992 |
| Aging of proteins: immunological detection of a glucose-derived pyrrole formed during Maillard reaction in vivo F Hayase, RH Nagaraj, S Miyata, FG Njoroge, VM Monnier Journal of Biological Chemistry 264 (7), 3758-3764, 1989 | 451 | 1989 |
| Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice M Liu, MS Bryant, J Chen, S Lee, B Yaremko, P Lipari, M Malkowski, ... Cancer research 58 (21), 4947-4956, 1998 | 393 | 1998 |
| SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon … BA Malcolm, R Liu, F Lahser, S Agrawal, B Belanger, N Butkiewicz, ... Antimicrobial agents and chemotherapy 50 (3), 1013-1020, 2006 | 390 | 2006 |
| Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3 … S Venkatraman, SL Bogen, A Arasappan, F Bennett, K Chen, E Jao, ... Journal of medicinal chemistry 49 (20), 6074-6086, 2006 | 319 | 2006 |
| Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection FG Njoroge, KX Chen, NY Shih, JJ Piwinski Accounts of chemical research 41 (1), 50-59, 2008 | 316 | 2008 |
| Novel Tricyclic Inhibitors of Farnesyl Protein Transferase: BIOCHEMICAL CHARACTERIZATION AND INHIBITION OF Ras MODIFICATION IN TRANSFECTED Cos CELLS (∗) WR Bishop, R Bond, J Petrin, L Wang, R Patton, R Doll, G Njoroge, ... Journal of Biological Chemistry 270 (51), 30611-30618, 1995 | 229 | 1995 |
| The chemistry of the Maillard reaction under physiological conditions: a review. FG Njoroge, VM Monnier Progress in clinical and biological research 304, 85-107, 1989 | 225 | 1989 |
| Peptides as NS3-serine protease inhibitors of hepatitis C virus AK Saksena, VM Girijavallabhan, RG Lovey, E Jao, F Bennett, ... US Patent 7,012,066, 2006 | 206 | 2006 |
| Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d). D Zhang, I Botos, FX Gomis-Rüth, R Doll, C Blood, FG Njoroge, JW Fox, ... Proceedings of the National Academy of Sciences 91 (18), 8447-8451, 1994 | 170 | 1994 |
| Detection of D-glucose-derived pyrrole compounds during Maillard reaction under physiological conditions FG Njoroge, LM Sayre, VM Monnier Carbohydrate research 167, 211-220, 1987 | 161 | 1987 |
| Characterization of resistance mutations against HCV ketoamide protease inhibitors X Tong, S Bogen, R Chase, V Girijavallabhan, Z Guo, FG Njoroge, ... Antiviral research 77 (3), 177-185, 2008 | 158 | 2008 |
| Mechanism of formation of the putative advanced glycosylation end product and protein cross-link 2-(2-furoyl)-4 (5)-(2-furanyl)-1H-imidazole. FG Njoroge, AA Fernandes, VM Monnier Journal of Biological Chemistry 263 (22), 10646-10652, 1988 | 148 | 1988 |
| (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH … FG Njoroge, AG Taveras, J Kelly, S Remiszewski, AK Mallams, R Wolin, ... Journal of medicinal chemistry 41 (24), 4890-4902, 1998 | 130 | 1998 |
| Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl … AJ Prongay, Z Guo, N Yao, J Pichardo, T Fischmann, C Strickland, ... Journal of medicinal chemistry 50 (10), 2310-2318, 2007 | 126 | 2007 |
| Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor: reduced RNA replication fitness and partial rescue by second-site mutations MK Yi, X Tong, A Skelton, R Chase, T Chen, A Prongay, SL Bogen, ... Journal of Biological Chemistry 281 (12), 8205-8215, 2006 | 122 | 2006 |
| Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure− activity relationships CL Strickland, PC Weber, WT Windsor, Z Wu, HV Le, MM Albanese, ... Journal of medicinal chemistry 42 (12), 2125-2135, 1999 | 113 | 1999 |
| Discovery of narlaprevir (SCH 900518): a potent, second generation HCV NS3 serine protease inhibitor A Arasappan, F Bennett, SL Bogen, S Venkatraman, M Blackman, ... ACS medicinal chemistry letters 1 (2), 64-69, 2010 | 105 | 2010 |
| A continuous spectrophotometric assay for the hepatitis C virus serine protease R Zhang, BM Beyer, J Durkin, R Ingram, FG Njoroge, WT Windsor, ... Analytical biochemistry 270 (2), 268-275, 1999 | 105 | 1999 |
| A review of HCV protease inhibitors. KX Chen, FG Njoroge Current Opinion in Investigational Drugs (London, England: 2000) 10 (8), 821-837, 2009 | 97 | 2009 |