The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity J Barretina, G Caponigro, N Stransky, K Venkatesan, AA Margolin, S Kim, ... Nature 483 (7391), 603-607, 2012 | 7937 | 2012 |
Tumor mutational load predicts survival after immunotherapy across multiple cancer types RM Samstein, CH Lee, AN Shoushtari, MD Hellmann, R Shen, ... Nature genetics 51 (2), 202-206, 2019 | 3273 | 2019 |
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients A Zehir, R Benayed, RH Shah, A Syed, S Middha, HR Kim, P Srinivasan, ... Nature medicine 23 (6), 703-713, 2017 | 3040 | 2017 |
Comprehensive molecular characterization of clear cell renal cell carcinoma CGAR Network Nature 499 (7456), 43-49, 2013 | 2888 | 2013 |
The mutational landscape of head and neck squamous cell carcinoma N Stransky, AM Egloff, AD Tward, AD Kostic, K Cibulskis, A Sivachenko, ... science 333 (6046), 1157-1160, 2011 | 2837 | 2011 |
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing GM Frampton, A Fichtenholtz, GA Otto, K Wang, SR Downing, J He, ... Nature biotechnology 31 (11), 1023-1031, 2013 | 2223 | 2013 |
OncoKB: a precision oncology knowledge base D Chakravarty, J Gao, S Phillips, R Kundra, H Zhang, J Wang, ... JCO precision oncology 1, 1-16, 2017 | 2112 | 2017 |
Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): a hybridization capture-based next-generation sequencing clinical assay for … DT Cheng, TN Mitchell, A Zehir, RH Shah, R Benayed, A Syed, ... The Journal of molecular diagnostics 17 (3), 251-264, 2015 | 1825 | 2015 |
Inherited DNA-repair gene mutations in men with metastatic prostate cancer CC Pritchard, J Mateo, MF Walsh, N De Sarkar, W Abida, H Beltran, ... New England Journal of Medicine 375 (5), 443-453, 2016 | 1644 | 2016 |
The genomic complexity of primary human prostate cancer MF Berger, MS Lawrence, F Demichelis, Y Drier, K Cibulskis, ... Nature 470 (7333), 214-220, 2011 | 1451 | 2011 |
Punctuated evolution of prostate cancer genomes SC Baca, D Prandi, MS Lawrence, JM Mosquera, A Romanel, Y Drier, ... Cell 153 (3), 666-677, 2013 | 1443 | 2013 |
AACR Project GENIE: powering precision medicine through an international consortium AACR Project Genie Consortium, AACR Project GENIE Consortium, ... Cancer discovery 7 (8), 818-831, 2017 | 1352 | 2017 |
Molecular determinants of response to anti–programmed cell death (PD)-1 and anti–programmed death-ligand 1 (PD-L1) blockade in patients with non–small-cell lung cancer profiled … H Rizvi, F Sanchez-Vega, K La, W Chatila, P Jonsson, D Halpenny, ... Journal of clinical oncology 36 (7), 633, 2018 | 1268 | 2018 |
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer W Toy, Y Shen, H Won, B Green, RA Sakr, M Will, Z Li, K Gala, S Fanning, ... Nature genetics 45 (12), 1439-1445, 2013 | 1248 | 2013 |
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling N Wagle, C Emery, MF Berger, MJ Davis, A Sawyer, P Pochanard, ... Journal of clinical oncology 29 (22), 3085, 2011 | 1204 | 2011 |
Diversity and complexity in DNA recognition by transcription factors G Badis, MF Berger, AA Philippakis, S Talukder, AR Gehrke, SA Jaeger, ... Science 324 (5935), 1720-1723, 2009 | 1155 | 2009 |
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers I Landa, T Ibrahimpasic, L Boucai, R Sinha, JA Knauf, RH Shah, S Dogan, ... The Journal of clinical investigation 126 (3), 1052-1066, 2016 | 1105 | 2016 |
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy D Chowell, LGT Morris, CM Grigg, JK Weber, RM Samstein, V Makarov, ... Science 359 (6375), 582-587, 2018 | 1031 | 2018 |
Extracellular vesicle and particle biomarkers define multiple human cancers A Hoshino, HS Kim, L Bojmar, KE Gyan, M Cioffi, J Hernandez, ... Cell 182 (4), 1044-1061. e18, 2020 | 895 | 2020 |
Melanoma genome sequencing reveals frequent PREX2 mutations MF Berger, E Hodis, TP Heffernan, YL Deribe, MS Lawrence, ... Nature 485 (7399), 502-506, 2012 | 889 | 2012 |