The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models A Kotschy, Z Szlavik, J Murray, J Davidson, AL Maragno, ... Nature 538 (7626), 477-482, 2016 | 1040 | 2016 |
Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia P Blombery, MA Anderson, J Gong, R Thijssen, RW Birkinshaw, ... Cancer discovery 9 (3), 342-353, 2019 | 408 | 2019 |
AMG 176, a selective MCL1 inhibitor, is effective in hematologic cancer models alone and in combination with established therapies S Caenepeel, SP Brown, B Belmontes, G Moody, KS Keegan, D Chui, ... Cancer discovery 8 (12), 1582-1597, 2018 | 385 | 2018 |
MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia XS Wang, JN Gong, J Yu, F Wang, XH Zhang, XL Yin, ZQ Tan, ZM Luo, ... Blood, The Journal of the American Society of Hematology 119 (21), 4992-5004, 2012 | 216 | 2012 |
Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations RW Birkinshaw, J Gong, CS Luo, D Lio, CA White, MA Anderson, ... Nature communications 10 (1), 2385, 2019 | 184 | 2019 |
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer D Merino, JR Whittle, F Vaillant, A Serrano, JN Gong, G Giner, ... Science translational medicine 9 (401), eaam7049, 2017 | 183 | 2017 |
MiR-181 family: regulators of myeloid differentiation and acute myeloid leukemia as well as potential therapeutic targets R Su, HS Lin, XH Zhang, XL Yin, HM Ning, B Liu, PF Zhai, JN Gong, ... Oncogene 34 (25), 3226-3239, 2015 | 177 | 2015 |
Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1 JN Gong, T Khong, D Segal, Y Yao, CD Riffkin, JM Garnier, SL Khaw, ... Blood, The Journal of the American Society of Hematology 128 (14), 1834-1844, 2016 | 153 | 2016 |
Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax P Blombery, ER Thompson, T Nguyen, RW Birkinshaw, J Gong, X Chen, ... Blood, The Journal of the American Society of Hematology 135 (10), 773-777, 2020 | 141 | 2020 |
The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia JN Gong, J Yu, HS Lin, XH Zhang, XL Yin, Z Xiao, F Wang, XS Wang, ... Cell Death & Differentiation 21 (1), 100-112, 2014 | 126 | 2014 |
Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer J Gong, J Li, Y Wang, C Liu, H Jia, C Jiang, Y Wang, M Luo, H Zhao, ... Carcinogenesis 35 (2), 497-506, 2014 | 115 | 2014 |
miR-29a and miR-142-3p downregulation and diagnostic implication in human acute myeloid leukemia F Wang, XS Wang, GH Yang, PF Zhai, Z Xiao, LY Xia, LR Chen, Y Wang, ... Molecular biology reports 39, 2713-2722, 2012 | 110 | 2012 |
IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos PL Fedele, SN Willis, Y Liao, MS Low, J Rautela, DH Segal, JN Gong, ... Blood, The Journal of the American Society of Hematology 132 (20), 2166-2178, 2018 | 84 | 2018 |
Multiple myeloma with 1q21 amplification is highly sensitive to MCL-1 targeting A Slomp, LM Moesbergen, J Gong, M Cuenca, PA von dem Borne, ... Blood Advances 3 (24), 4202-4214, 2019 | 82 | 2019 |
Chemotherapy-induced miRNA-29c/catenin-δ signaling suppresses metastasis in gastric cancer Y Wang, C Liu, M Luo, Z Zhang, J Gong, J Li, L You, L Dong, R Su, H Lin, ... Cancer research 75 (7), 1332-1344, 2015 | 72 | 2015 |
KRAS-enhanced macropinocytosis and reduced FcRn-mediated recycling sensitize pancreatic cancer to albumin-conjugated drugs H Liu, M Sun, Z Liu, C Kong, W Kong, J Ye, J Gong, DCS Huang, F Qian Journal of Controlled Release 296, 40-53, 2019 | 54 | 2019 |
miR-199a-5p inhibits monocyte/macrophage differentiation by targeting the activin A type 1B receptor gene and finally reducing C/EBPα expression HS Lin, JN Gong, R Su, MT Chen, L Song, C Shen, F Wang, YN Ma, ... Journal of leukocyte biology 96 (6), 1023-1035, 2014 | 48 | 2014 |
Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma P Blombery, RW Birkinshaw, T Nguyen, J Gong, ER Thompson, Z Xu, ... Br J Haematol 186 (6), e188-e191, 2019 | 47 | 2019 |
MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1: NOXA complex TM Djajawi, L Liu, J Gong, AS Huang, M Luo, Z Xu, T Okamoto, MJ Call, ... Cell Death & Differentiation 27 (8), 2484-2499, 2020 | 44 | 2020 |
Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells CE Teh, JN Gong, D Segal, T Tan, CJ Vandenberg, PL Fedele, MSY Low, ... Cell Death & Differentiation 27 (7), 2217-2233, 2020 | 37 | 2020 |