Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug E Mastrangelo, M Pezzullo, T De Burghgraeve, S Kaptein, B Pastorino, ... Journal of Antimicrobial Chemotherapy 67 (8), 1884-1894, 2012 | 467 | 2012 |
Structure and functionality in flavivirus NS-proteins: perspectives for drug design M Bollati, K Alvarez, R Assenberg, C Baronti, B Canard, S Cook, ... Antiviral research 87 (2), 125-148, 2010 | 448 | 2010 |
Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme M Milani, A Pesce, Y Ouellet, P Ascenzi, M Guertin, M Bolognesi The EMBO journal, 2001 | 239 | 2001 |
Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication R Assenberg, E Mastrangelo, TS Walter, A Verma, M Milani, RJ Owens, ... Journal of virology 83 (24), 12895-12906, 2009 | 184 | 2009 |
Structural bases for heme binding and diatomic ligand recognition in truncated hemoglobins M Milani, A Pesce, M Nardini, H Ouellet, Y Ouellet, S Dewilde, A Bocedi, ... Journal of inorganic biochemistry 99 (1), 97-109, 2005 | 157 | 2005 |
Heme-ligand tunneling in group I truncated hemoglobins M Milani, A Pesce, Y Ouellet, S Dewilde, J Friedman, P Ascenzi, ... Journal of Biological Chemistry 279 (20), 21520-21525, 2004 | 142 | 2004 |
A TyrCD1/TrpG8 hydrogen bond network and a TyrB10—TyrCD1 covalent link shape the heme distal site of Mycobacterium tuberculosis hemoglobin O M Milani, PY Savard, H Ouellet, P Ascenzi, M Guertin, M Bolognesi Proceedings of the National Academy of Sciences 100 (10), 5766-5771, 2003 | 127 | 2003 |
Ligand‐induced dynamical regulation of NO conversion in Mycobacterium tuberculosis truncated hemoglobin‐N A Bidon‐Chanal, MA Martí, A Crespo, M Milani, M Orozco, M Bolognesi, ... Proteins: Structure, Function, and Bioinformatics 64 (2), 457-464, 2006 | 113 | 2006 |
Structure-based inhibition of Norovirus RNA-dependent RNA polymerases E Mastrangelo, M Pezzullo, D Tarantino, R Petazzi, F Germani, D Kramer, ... Journal of molecular biology 419 (3-4), 198-210, 2012 | 112 | 2012 |
Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein E Mastrangelo, M Milani, M Bollati, B Selisko, F Peyrane, V Pandini, ... Journal of molecular biology 372 (2), 444-455, 2007 | 101 | 2007 |
FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation M Milani, F Ciriello, S Baroni, V Pandini, G Canevari, M Bolognesi, ... Journal of molecular biology 411 (2), 463-473, 2011 | 99 | 2011 |
Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus M Bollati, M Milani, E Mastrangelo, S Ricagno, G Tedeschi, S Nonnis, ... Journal of molecular biology 385 (1), 140-152, 2009 | 93 | 2009 |
Targeting the BIR domains of inhibitor of apoptosis (IAP) proteins in cancer treatment F Cossu, M Milani, E Mastrangelo, D Lecis Computational and Structural Biotechnology Journal 17, 142-150, 2019 | 89 | 2019 |
Protein fold and structure in the truncated (2/2) globin family M Nardini, A Pesce, M Milani, M Bolognesi Gene 398 (1-2), 2-11, 2007 | 86 | 2007 |
Cyanide Binding to Truncated Hemoglobins: A Crystallographic and Kinetic Study, M Milani, Y Ouellet, H Ouellet, M Guertin, A Boffi, G Antonini, A Bocedi, ... Biochemistry 43 (18), 5213-5221, 2004 | 77 | 2004 |
Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition M Milani, E Mastrangelo, M Bollati, B Selisko, E Decroly, M Bouvet, ... Antiviral research 83 (1), 28-34, 2009 | 73 | 2009 |
Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2 F Cossu, E Mastrangelo, M Milani, G Sorrentino, D Lecis, D Delia, ... Biochemical and biophysical research communications 378 (2), 162-167, 2009 | 73 | 2009 |
Glycine amidinotransferase (GATM), renal Fanconi syndrome, and kidney failure M Reichold, ED Klootwijk, J Reinders, EA Otto, M Milani, C Broeker, ... Journal of the American Society of Nephrology 29 (7), 1849-1858, 2018 | 68 | 2018 |
Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds R Croci, M Pezzullo, D Tarantino, M Milani, SC Tsay, R Sureshbabu, ... PloS one 9 (3), e91765, 2014 | 63 | 2014 |
Mycobacterial truncated hemoglobins: from genes to functions P Ascenzi, M Bolognesi, M Milani, M Guertin, P Visca Gene 398 (1-2), 42-51, 2007 | 63 | 2007 |