Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities DC Porter, E Farmaki, S Altilia, GP Schools, DK West, M Chen, BD Chang, ... Proceedings of the National Academy of Sciences 109 (34), 13799-13804, 2012 | 217 | 2012 |
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB M Chen, J Liang, H Ji, Z Yang, S Altilia, B Hu, A Schronce, ... Proceedings of the National Academy of Sciences 114 (38), 10208-10213, 2017 | 132 | 2017 |
Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer MSJ McDermott, AA Chumanevich, C Lim, J Liang, M Chen, S Altilia, ... Oncotarget 8 (8), 12558, 2017 | 131 | 2017 |
Expression of CDK8 and CDK8-interacting genes as potential biomarkers in breast cancer E V Broude, B Gyorffy, A A Chumanevich, M Chen, M SJ McDermott, ... Current cancer drug targets 15 (8), 739-749, 2015 | 104 | 2015 |
CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases J Liang, M Chen, D Hughes, AA Chumanevich, S Altilia, V Kaza, CU Lim, ... Cancer research 78 (23), 6594-6606, 2018 | 93 | 2018 |
Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells M Chen, M Tanner, AC Levine, E Levina, P Ohouo, R Buttyan Cell cycle (Georgetown, Tex.) 8 (1), 149, 2009 | 86 | 2009 |
Editorial Comment on: Hedgehog Signalling in Androgen Independent Prostate Cancer M Chen, R Buttyan European Urology 54 (6), 1341-1343, 2008 | 80* | 2008 |
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance M Nouri, J Caradec, AA Lubik, N Li, BG Hollier, M Takhar, ... Oncotarget 8 (12), 18949, 2017 | 74 | 2017 |
Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells M Chen, MA Feuerstein, E Levina, PS Baghel, RD Carkner, MJ Tanner, ... Molecular cancer 9, 1-12, 2010 | 74 | 2010 |
The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells M Chen, LM Chen, CY Lin, KX Chai Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1783 (5), 896-903, 2008 | 74 | 2008 |
Effects of androgen receptor and androgen on gene expression in prostate stromal fibroblasts and paracrine signaling to prostate cancer cells MJ Tanner, RC Welliver, M Chen, M Shtutman, A Godoy, G Smith, ... PloS one 6 (1), e16027, 2011 | 68 | 2011 |
Gli2 expression and human bladder transitional carcinoma cell invasiveness CW Mechlin, MJ Tanner, M Chen, R Buttyan, RM Levin, BM Mian The Journal of urology 184 (1), 344-351, 2010 | 59 | 2010 |
The hedgehog/Gli signaling paradigm in prostate cancer M Chen, R Carkner, R Buttyan Expert review of endocrinology & metabolism 6 (3), 453, 2011 | 56 | 2011 |
Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor M Chen, LM Chen, CY Lin, KX Chai Molecular and cellular biochemistry 337 (1), 259-266, 2010 | 52 | 2010 |
The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor H Wang, M Jiang, H Cui, M Chen, R Buttyan, SW Hayward, T Hai, Z Wang, ... Molecular and cellular biology, 2012 | 49 | 2012 |
Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3 M Chen, YY Fu, CY Lin, LM Chen, KX Chai Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1773 (7), 1133-1140, 2007 | 43 | 2007 |
Systemic toxicity reported for CDK8/19 inhibitors CCT251921 and MSC2530818 is not due to target inhibition M Chen, J Li, J Liang, ZS Thompson, K Kathrein, EV Broude, IB Roninson Cells 8 (11), 1413, 2019 | 42 | 2019 |
Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen D Oliver, H Ji, P Liu, A Gasparian, E Gardiner, S Lee, A Zenteno, ... Scientific reports 7 (1), 43023, 2017 | 41 | 2017 |
Identifying cancers impacted by CDK8/19 IB Roninson, B Győrffy, ZT Mack, AA Shtil, MS Shtutman, M Chen, ... Cells 8 (8), 821, 2019 | 40 | 2019 |
Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation LM Chen, C Wang, M Chen, MR Marcello, J Chao, L Chao, KX Chai American Journal of Physiology-Renal Physiology 291 (3), F567-F577, 2006 | 40 | 2006 |