Kemp elimination catalysts by computational enzyme design D Röthlisberger, O Khersonsky, AM Wollacott, L Jiang, J DeChancie, ... Nature 453 (7192), 190-195, 2008 | 1549 | 2008 |
Man-made cell-like compartments for molecular evolution DS Tawfik, AD Griffiths Nature biotechnology 16 (7), 652-656, 1998 | 1526 | 1998 |
Enzyme promiscuity: a mechanistic and evolutionary perspective OKDS Tawfik Annual review of biochemistry 79 (1), 471-505, 2010 | 1475 | 2010 |
The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters A Bar-Even, E Noor, Y Savir, W Liebermeister, D Davidi, DS Tawfik, ... Biochemistry 50 (21), 4402-4410, 2011 | 1096 | 2011 |
The'evolvability'of promiscuous protein functions A Aharoni, L Gaidukov, O Khersonsky, SMQ Gould, C Roodveldt, ... Nature genetics 37 (1), 73-76, 2005 | 1009 | 2005 |
Protein dynamism and evolvability N Tokuriki, DS Tawfik Science 324 (5924), 203-207, 2009 | 979 | 2009 |
Stability effects of mutations and protein evolvability N Tokuriki, DS Tawfik Current opinion in structural biology 19 (5), 596-604, 2009 | 931 | 2009 |
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes M Harel, A Aharoni, L Gaidukov, B Brumshtein, O Khersonsky, R Meged, ... Nature structural & molecular biology 11 (5), 412-419, 2004 | 877 | 2004 |
Antibody multispecificity mediated by conformational diversity LC James, P Roversi, DS Tawfik Science 299 (5611), 1362-1367, 2003 | 829 | 2003 |
Enzyme promiscuity: evolutionary and mechanistic aspects O Khersonsky, C Roodveldt, DS Tawfik Current opinion in chemical biology 10 (5), 498-508, 2006 | 748 | 2006 |
Conformational diversity and protein evolution–a 60-year-old hypothesis revisited LC James, DS Tawfik Trends in biochemical sciences 28 (7), 361-368, 2003 | 687 | 2003 |
How protein stability and new functions trade off N Tokuriki, F Stricher, L Serrano, DS Tawfik PLoS computational biology 4 (2), e1000002, 2008 | 607 | 2008 |
Local fitness landscape of the green fluorescent protein KS Sarkisyan, DA Bolotin, MV Meer, DR Usmanova, AS Mishin, ... Nature 533 (7603), 397-401, 2016 | 594 | 2016 |
Amplification of complex gene libraries by emulsion PCR R Williams, SG Peisajovich, OJ Miller, S Magdassi, DS Tawfik, AD Griffiths Nature methods 3 (7), 545-550, 2006 | 561 | 2006 |
Miniaturising the laboratory in emulsion droplets AD Griffiths, DS Tawfik Trends in biotechnology 24 (9), 395-402, 2006 | 557 | 2006 |
Structure− reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase O Khersonsky, DS Tawfik Biochemistry 44 (16), 6371-6382, 2005 | 542 | 2005 |
In vitro sorting method A Griffiths, D Tawfik US Patent 7,638,276, 2009 | 539* | 2009 |
Automated structure-and sequence-based design of proteins for high bacterial expression and stability A Goldenzweig, M Goldsmith, SE Hill, O Gertman, P Laurino, Y Ashani, ... Molecular cell 63 (2), 337-346, 2016 | 502 | 2016 |
Robustness–epistasis link shapes the fitness landscape of a randomly drifting protein S Bershtein, M Segal, R Bekerman, N Tokuriki, DS Tawfik Nature 444 (7121), 929-932, 2006 | 470 | 2006 |
Mutational effects and the evolution of new protein functions M Soskine, DS Tawfik Nature Reviews Genetics 11 (8), 572-582, 2010 | 469 | 2010 |