Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions CP Guimaraes, MD Witte, CS Theile, G Bozkurt, L Kundrat, AEM Blom, ... Nature protocols 8 (9), 1787-1799, 2013 | 395 | 2013 |
Site-specific N-terminal labeling of proteins using sortase-mediated reactions CS Theile, MD Witte, AEM Blom, L Kundrat, HL Ploegh, CP Guimaraes Nature protocols 8 (9), 1800-1807, 2013 | 306 | 2013 |
Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes J Shi, L Kundrat, N Pishesha, A Bilate, C Theile, T Maruyama, SK Dougan, ... Proceedings of the National Academy of Sciences 111 (28), 10131-10136, 2014 | 232 | 2014 |
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates CR Brown, S Gupta, J Qin, T Racie, G He, S Lentini, R Malone, M Yu, ... Nucleic acids research 48 (21), 11827-11844, 2020 | 189 | 2020 |
5′‐(E)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates R Parmar, JLS Willoughby, J Liu, DJ Foster, B Brigham, CS Theile, ... ChemBioChem 17 (11), 985-989, 2016 | 137 | 2016 |
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates KM Brown, JK Nair, MM Janas, YI Anglero-Rodriguez, LTH Dang, H Peng, ... Nature biotechnology 40 (10), 1500-1508, 2022 | 135 | 2022 |
Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry MD Witte, CS Theile, T Wu, CP Guimaraes, AEM Blom, HL Ploegh Nature protocols 8 (9), 1808-1819, 2013 | 81 | 2013 |
siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2 E Elkayam, R Parmar, CR Brown, JL Willoughby, CS Theile, ... Nucleic acids research 45 (6), 3528-3536, 2017 | 80 | 2017 |
Site-specific protein modification using immobilized sortase in batch and continuous-flow systems MD Witte, T Wu, CP Guimaraes, CS Theile, AEM Blom, JR Ingram, Z Li, ... Nature Protocols 10 (3), 508-516, 2015 | 74 | 2015 |
Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells AM Avalos, AM Bilate, MD Witte, AK Tai, J He, MP Frushicheva, PD Thill, ... Journal of Experimental Medicine 211 (2), 365-379, 2014 | 63 | 2014 |
Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors I Wuethrich, JGC Peeters, AEM Blom, CS Theile, Z Li, E Spooner, ... PLoS One 9 (10), e109883, 2014 | 54 | 2014 |
Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling AS Jahan, M Lestra, LK Swee, Y Fan, MM Lamers, FG Tafesse, CS Theile, ... Proceedings of the National Academy of Sciences 113 (6), E705-E714, 2016 | 53 | 2016 |
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence … R McDougall, D Ramsden, S Agarwal, S Agarwal, K Aluri, M Arciprete, ... Drug Metabolism and Disposition 50 (6), 781-797, 2022 | 48 | 2022 |
Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates RG Parmar, CR Brown, S Matsuda, JLS Willoughby, CS Theile, ... Journal of medicinal chemistry 61 (3), 734-744, 2018 | 46 | 2018 |
A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short‐term plasticity and vesicle number BJ Walters, JJ Hallengren, CS Theile, HL Ploegh, SM Wilson, LE Dobrunz The Journal of physiology 592 (4), 571-586, 2014 | 44 | 2014 |
Centyrin ligands for extrahepatic delivery of siRNA D Klein, S Goldberg, CS Theile, R Dambra, K Haskell, E Kuhar, T Lin, ... Molecular Therapy 29 (6), 2053-2066, 2021 | 37 | 2021 |
Generation and validation of structurally defined antibody–siRNA conjugates AR Nanna, AV Kel’in, C Theile, JM Pierson, ZX Voo, A Garg, JK Nair, ... Nucleic Acids Research 48 (10), 5281-5293, 2020 | 36 | 2020 |
Fluorophore‐Conjugated Holliday Junctions for Generating Super‐Bright Antibodies and Antibody Fragments Z Li, CS Theile, GY Chen, AM Bilate, JN Duarte, AM Avalos, T Fang, ... Angewandte Chemie International Edition 54 (40), 11706-11710, 2015 | 32 | 2015 |
Graphene Oxide Nanosheets Modified with Single‐Domain Antibodies for Rapid and Efficient Capture of Cells GY Chen, Z Li, CS Theile, NM Bardhan, PV Kumar, JN Duarte, ... Chemistry–A European Journal 21 (48), 17178-17183, 2015 | 22 | 2015 |
The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man S Chong, S Agarwal, S Agarwal, KC Aluri, M Arciprete, C Brown, ... Drug Metabolism and Disposition, 2021 | 19 | 2021 |