Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion GW Irvine, TBJ Pinter, MJ Stillman Metallomics 8 (1), 71-81, 2016 | 55 | 2016 |
Unravelling the mechanistic details of metal binding to mammalian metallothioneins from stoichiometric, kinetic, and binding affinity data JS Scheller, GW Irvine, MJ Stillman Dalton transactions 47 (11), 3613-3637, 2018 | 48 | 2018 |
Stepwise copper(i) binding to metallothionein: a mixed cooperative and non-cooperative mechanism for all 20 copper ions JS Scheller, GW Irvine, DL Wong, A Hartwig, MJ Stillman Metallomics 9 (5), 447-462, 2017 | 46 | 2017 |
A simple metallothionein-based biosensor for enhanced detection of arsenic and mercury GW Irvine, SN Tan, MJ Stillman Biosensors 7 (1), 14, 2017 | 46 | 2017 |
Cysteine accessibility during As3+ metalation of the α-and β-domains of recombinant human MT1a GW Irvine, KL Summers, MJ Stillman Biochemical and Biophysical Research Communications 433 (4), 477-483, 2013 | 36 | 2013 |
Domain selection in metallothionein 1a: Affinity-controlled mechanisms of zinc binding and cadmium exchange TBJ Pinter, GW Irvine, MJ Stillman Biochemistry 54 (32), 5006-5016, 2015 | 28 | 2015 |
Metalation kinetics of the human α‐metallothionein 1a fragment is dependent on the fluxional structure of the apo‐protein GW Irvine, KER Duncan, M Gullons, MJ Stillman Chemistry–A European Journal 21 (3), 1269-1279, 2015 | 27 | 2015 |
Selective cysteine modification of metal‐free human metallothionein 1a and its isolated domain fragments: Solution structural properties revealed via ESI‐MS GW Irvine, M Santolini, MJ Stillman Protein Science 26 (5), 960-971, 2017 | 22 | 2017 |
Topographical analysis of As-induced folding of α-MT1a GW Irvine, MJ Stillman Biochemical and Biophysical Research Communications 441 (1), 208-213, 2013 | 18 | 2013 |
Residue modification and mass spectrometry for the investigation of structural and metalation properties of metallothionein and cysteine-rich proteins GW Irvine, MJ Stillman International journal of molecular sciences 18 (5), 913, 2017 | 15 | 2017 |
Cadmium binding mechanisms of isolated domains of human MT isoform 1a: Non-cooperative terminal sites and cooperative cluster sites GW Irvine, MJ Stillman Journal of Inorganic Biochemistry 158, 115-121, 2016 | 13 | 2016 |
Isolated domains of recombinant human apo-metallothionein 1A are folded at neutral pH: a denaturant and heat-induced unfolding study using ESI-MS GW Irvine, N Korkola, MJ Stillman Bioscience Reports 38 (4), BSR20180592, 2018 | 12 | 2018 |
Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion, Metallomics, 2016, 8 (1), 71–81 GW Irvine, TB Pinter, MJ Stillman | 9 | |
Formation of oxidative and non‐oxidative dimers in metallothioneins: Implications for charge‐state analysis for structural determination GW Irvine, L Heinlein, JB Renaud, MW Sumarah, MJ Stillman Rapid Communications in Mass Spectrometry 31 (24), 2118-2124, 2017 | 7 | 2017 |
Coordination promiscuity guarantees metal substrate selection in transmembrane primary-active Zn 2+ pumps MJ Gallenito, GW Irvine, L Zhang, G Meloni Chemical Communications 55 (73), 10844-10847, 2019 | 6 | 2019 |
An overview of the “-omics” fields at the forefront of next-generation personalized medicine and fundamental systems biology studies GW Irvine, S Nguyen Biomedical Genetics and Genomics 4 (2), 1-6, 2019 | 5 | 2019 |
Chromatographic separation of similar post-translationally modified metallothioneins reveals the changing conformations of apo-MT upon cysteine alkylation by high resolution LC … GW Irvine, MJ Stillman Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1866 (5-6), 589-601, 2018 | 3 | 2018 |
Plastic recognition and electrogenic uniport translocation of 1 st-, 2 nd-, and 3 rd-row transition and post-transition metals by primary-active transmembrane P 1B-2-type … SS Abeyrathna, NS Abeyrathna, P Basak, GW Irvine, L Zhang, G Meloni Chemical Science 14 (22), 6059-6078, 2023 | 2 | 2023 |
Metal Substrate Selectivity and Mechanism of Transport in a Transmembrane Zn‐pump Revealed by in‐vitro Real‐time Transport S Abeyrathna, N Abeyrathna, G Irvine, P Basak, G Meloni The FASEB Journal 35, 2021 | | 2021 |
Metalation and Structural Properties of apo-Metallothioneins GW Irvine The University of Western Ontario (Canada), 2017 | | 2017 |