Improved glucose homeostasis in obese mice treated with resveratrol is associated with alterations in the gut microbiome MM Sung, TT Kim, E Denou, CLM Soltys, SM Hamza, NJ Byrne, ... Diabetes 66 (2), 418-425, 2017 | 211 | 2017 |
Empagliflozin blunts worsening cardiac dysfunction associated with reduced NLRP3 (nucleotide-binding domain-like receptor protein 3) inflammasome activation in heart failure NJ Byrne, N Matsumura, ZH Maayah, M Ferdaoussi, S Takahara, ... Circulation: Heart Failure 13 (1), e006277, 2020 | 188 | 2020 |
Empagliflozin prevents worsening of cardiac function in an experimental model of pressure overload-induced heart failure NJ Byrne, N Parajuli, JL Levasseur, J Boisvenue, DL Beker, G Masson, ... Basic to Translational Science 2 (4), 347-354, 2017 | 179 | 2017 |
Cardiac late sodium channel current is a molecular target for the sodium/glucose cotransporter 2 inhibitor empagliflozin K Philippaert, S Kalyaanamoorthy, M Fatehi, W Long, S Soni, NJ Byrne, ... Circulation 143 (22), 2188-2204, 2021 | 152 | 2021 |
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy NJ Byrne, NS Rajasekaran, ED Abel, H Bugger Free Radical Biology and Medicine 169, 317-342, 2021 | 113 | 2021 |
Resveratrol treatment of mice with pressure-overload–induced heart failure improves diastolic function and cardiac energy metabolism MM Sung, SK Das, J Levasseur, NJ Byrne, D Fung, TT Kim, G Masson, ... Circulation: Heart Failure 8 (1), 128-137, 2015 | 105 | 2015 |
Resveratrol improves exercise performance and skeletal muscle oxidative capacity in heart failure MM Sung, NJ Byrne, IM Robertson, TT Kim, V Samokhvalov, J Levasseur, ... American Journal of Physiology-Heart and Circulatory Physiology 312 (4 …, 2017 | 88 | 2017 |
Chronically elevating circulating ketones can reduce cardiac inflammation and blunt the development of heart failure NJ Byrne, S Soni, S Takahara, M Ferdaoussi, R Al Batran, AM Darwesh, ... Circulation: Heart Failure 13 (6), e006573, 2020 | 80 | 2020 |
Cardiomyocyte-specific ablation of CD36 accelerates the progression from compensated cardiac hypertrophy to heart failure MM Sung, NJ Byrne, TT Kim, J Levasseur, G Masson, JJ Boisvenue, ... American Journal of Physiology-Heart and Circulatory Physiology 312 (3 …, 2017 | 55 | 2017 |
Pimozide alleviates hyperglycemia in diet-induced obesity by inhibiting skeletal muscle ketone oxidation R Al Batran, K Gopal, ME Capozzi, JJ Chahade, B Saleme, ... Cell Metabolism 31 (5), 909-919. e8, 2020 | 53 | 2020 |
Malonyl CoA decarboxylase inhibition improves cardiac function post-myocardial infarction W Wang, L Zhang, PK Battiprolu, A Fukushima, K Nguyen, K Milner, ... JACC: Basic to Translational Science 4 (3), 385-400, 2019 | 48 | 2019 |
Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites N Matsumura, S Takahara, ZH Maayah, N Parajuli, NJ Byrne, SM Shoieb, ... Journal of molecular and cellular cardiology 125, 162-173, 2018 | 41 | 2018 |
Normalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regression NJ Byrne, J Levasseur, MM Sung, G Masson, J Boisvenue, ME Young, ... Cardiovascular research 110 (2), 249-257, 2016 | 41 | 2016 |
Animal models of dysregulated cardiac metabolism H Bugger, NJ Byrne, ED Abel Circulation research 130 (12), 1965-1993, 2022 | 19 | 2022 |
TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure MA Lorenzana-Carrillo, K Gopal, NJ Byrne, S Tejay, B Saleme, SK Das, ... Science Translational Medicine 14 (669), eabm3565, 2022 | 11 | 2022 |
Effects of short term adiponectin receptor agonism on cardiac function and energetics in diabetic db/db mice A Tarkhnishvili, C Koentges, K Pfeil, J Gollmer, NJ Byrne, I Vosko, J Lueg, ... Journal of lipid and atherosclerosis 11 (2), 161, 2022 | 9 | 2022 |
The role of AMPK in the control of cardiac hypertrophy NJ Byrne, MM Sung, JRB Dyck Cardiac energy metabolism in health and disease, 199-220, 2014 | 4 | 2014 |
cell-specific regulation of the GATA-4/6 transcription factors by the metabolic enzyme PKM2 provides insight into a biologic function essential for cardiac health and survival MAL Carrillo, K Gopal, NJ Byrne, B Saleme, SK Das, S Tejay, Y Zhang, ... Circulation 144, 2021 | 1 | 2021 |
Cardiomyocyte‐Specific Ablation of the Long‐Chain Fatty Acid Transporter CD36 Accelerates the Progression of Pressure Overload‐Induced Heart Failure in Mice M Sung, N Byrne, J Levasseur, G Masson, M Febbraio, J Dyck The FASEB Journal 29, LB593, 2015 | 1 | 2015 |
Transient Inhibition of Translation Improves Cardiac Function After Ischemia/Reperfusion by Attenuating the Inflammatory Response C Hofmann, A Serafin, OM Schwerdt, J Fischer, F Sicklinger, FS Younesi, ... Circulation, 2024 | | 2024 |