Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. R Perona, S Montaner, L Saniger, I Sanchez-Perez, R Bravo, JC Lacal Genes & development 11 (4), 463-475, 1997 | 792 | 1997 |
Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers AR de Molina, A Rodrı́guez-González, R Gutiérrez, L Martı́nez-Piñeiro, ... Biochemical and biophysical research communications 296 (3), 580-583, 2002 | 425 | 2002 |
Rho signals to cell growth and apoptosis S Aznar, JC Lacal Cancer letters 165 (1), 1-10, 2001 | 404 | 2001 |
Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene JC Lacal, J Moscat, SA Aaronson Nature 330 (6145), 269-272, 1987 | 354 | 1987 |
Rho GTPase expression in tumourigenesis: evidence for a significant link TG Del Pulgar, SA Benitah, PF Valerón, C Espina, JC Lacal Bioessays 27 (6), 602-613, 2005 | 327 | 2005 |
Multiple signalling pathways lead to the activation of the nuclear factor κB by the Rho family of GTPases S Montaner, R Perona, L Saniger, JC Lacal Journal of Biological Chemistry 273 (21), 12779-12785, 1998 | 298 | 1998 |
Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy A Ramírez de Molina, R Gutiérrez, MA Ramos, JM Silva, J Silva, F Bonilla, ... Oncogene 21 (27), 4317-4322, 2002 | 295 | 2002 |
Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites MV Céspedes, C Espina, MA García-Cabezas, M Trias, A Boluda, ... The American journal of pathology 170 (3), 1077-1085, 2007 | 225 | 2007 |
Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. A Cuadrado, A Carnero, F Dolfi, B Jiménez, JC Lacal Oncogene 8 (11), 2959-2968, 1993 | 224 | 1993 |
Rho proteins induce metastatic properties in vivo L Peso, R Hernández-Alcoceba, N Embade, A Carnero, P Esteve, C Paje, ... Oncogene 15 (25), 3047-3057, 1997 | 218 | 1997 |
Choline kinase inhibitors as a novel approach for antiproliferative drug design R Hernández-Alcoceba, L Saniger, J Campos, MC Núñez, F Khaless, ... Oncogene 15 (19), 2289-2301, 1997 | 211 | 1997 |
Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation SA Benitah, PF Valerón, L Van Aelst, CJ Marshall, JC Lacal Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1705 (2), 121-132, 2004 | 200 | 2004 |
A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets. EG Lapetina, JC Lacal, BR Reep, L Molina y Vedia Proceedings of the National Academy of Sciences 86 (9), 3131-3134, 1989 | 191 | 1989 |
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study AR de Molina, J Sarmentero-Estrada, C Belda-Iniesta, M Tarón, ... The lancet oncology 8 (10), 889-897, 2007 | 183 | 2007 |
In Vivo Antitumor Activity of Choline Kinase Inhibitors: A Novel Target for Anticancer Drug Discovery R Hernández-Alcoceba, F Fernández, JC Lacal Cancer research 59 (13), 3112-3118, 1999 | 182 | 1999 |
Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models NMS Al-Saffar, H Troy, AR de Molina, LE Jackson, B Madhu, JR Griffiths, ... Cancer research 66 (1), 427-434, 2006 | 173 | 2006 |
Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression AR de Molina, M Bánez-Coronel, R Gutiérrez, A Rodríguez-González, ... Cancer research 64 (18), 6732-6739, 2004 | 171 | 2004 |
Choline uptake and metabolism modulate macrophage IL-1β and IL-18 production E Sanchez-Lopez, Z Zhong, A Stubelius, SR Sweeney, LM Booshehri, ... Cell metabolism 29 (6), 1350-1362. e7, 2019 | 169 | 2019 |
Rho GTPases: potential candidates for anticancer therapy S Aznar, P Fernández-Valerón, C Espina, JC Lacal Cancer letters 206 (2), 181-191, 2004 | 160 | 2004 |
Tumorigenic activity of rho genes from Aplysia californica. R Perona, P Esteve, B Jimenez, RP Ballestero, JC Lacal Oncogene 8 (5), 1285-1292, 1993 | 157 | 1993 |