| Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization WJ Thomsen, AJ Grottick, F Menzaghi, H Reyes-Saldana, S Espitia, ... Journal of Pharmacology and Experimental Therapeutics 325 (2), 577-587, 2008 | 490 | 2008 |
| Differential effects of the 5-HT2A receptor antagonist M100, 907 and the 5-HT2C receptor antagonist SB242, 084 on cocaine-induced locomotor activity, cocaine self … PJ Fletcher, AJ Grottick, GA Higgins Neuropsychopharmacology 27 (4), 576-586, 2002 | 304 | 2002 |
| Discovery and structure− activity relationship of (1 R)-8-chloro-2, 3, 4, 5-tetrahydro-1-methyl-1 H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist … BM Smith, JM Smith, JH Tsai, JA Schultz, CA Gilson, SA Estrada, ... Journal of medicinal chemistry 51 (2), 305-313, 2008 | 273 | 2008 |
| Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task AJ Grottick, GA Higgins Behavioural brain research 117 (1-2), 197-208, 2000 | 268 | 2000 |
| Studies to investigate the role of 5-HT2C receptors on cocaine-and food-maintained behavior AJ Grottick, PJ Fletcher, GA Higgins Journal of Pharmacology and Experimental therapeutics 295 (3), 1183-1191, 2000 | 257 | 2000 |
| Evidence that nicotinic α7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine AJ Grottick, G Trube, WA Corrigall, J Huwyler, P Malherbe, R Wyler, ... Journal of Pharmacology and Experimental Therapeutics 294 (3), 1112-1119, 2000 | 186 | 2000 |
| Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119 G Semple, B Fioravanti, G Pereira, I Calderon, J Uy, K Choi, Y Xiong, ... Journal of medicinal chemistry 51 (17), 5172-5175, 2008 | 161 | 2008 |
| Activation of 5-HT2C receptors reduces the locomotor and rewarding effects of nicotine A Grottick, W Corrigall, G Higgins Psychopharmacology 157, 292-298, 2001 | 145 | 2001 |
| Anxiolytic-and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists S Chaki, T Funakoshi, S Hirota-Okuno, M Nishiguchi, T Shimazaki, ... Journal of Pharmacology and Experimental Therapeutics 313 (2), 831-839, 2005 | 143 | 2005 |
| Spatial and associative learning deficits induced by neonatal excitotoxic hippocampal damage in rats: further evaluation of an animal model of schizophrenia G Le Pen, AJ Grottick, GA Higgins, JR Martin, F Jenck, JL Moreau Behavioural Pharmacology 11 (3 & 4), 257-268, 2000 | 118 | 2000 |
| A double dissociation between serial reaction time and radial maze performance in rats subjected to 192 IgG‐saporin lesions of the nucleus basalis and/or the septal region O Lehmann, AJ Grottick, JC Cassel, GA Higgins European Journal of Neuroscience 18 (3), 651-666, 2003 | 109 | 2003 |
| Effect of LSD on prepulse inhibition and spontaneous behavior in the rat: A pharmacological analysis and comparison between two rat strains AM Ouagazzal, AJ Grottick, JL Moreau, GA Higgins Neuropsychopharmacology 25 (4), 565-575, 2001 | 107 | 2001 |
| Phencyclidine exacerbates attentional deficits in a neurodevelopmental rat model of schizophrenia G Le Pen, AJ Grottick, GA Higgins, JL Moreau Neuropsychopharmacology 28 (10), 1799-1809, 2003 | 92 | 2003 |
| Assessing a vigilance decrement in aged rats: effects of pre-feeding, task manipulation, and psychostimulants AJ Grottick, GA Higgins Psychopharmacology 164, 33-41, 2002 | 92 | 2002 |
| A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory GA Higgins, JNC Kew, JG Richards, H Takeshima, F Jenck, G Adam, ... European Journal of Neuroscience 15 (5), 911-922, 2002 | 89 | 2002 |
| Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function GA Higgins, AJ Grottick, TM Ballard, JG Richards, J Messer, H Takeshima, ... Neuropharmacology 41 (1), 97-107, 2001 | 79 | 2001 |
| The potential use of selective 5-HT2C agonists in treating obesity BM Smith, WJ Thomsen, AJ Grottick Expert opinion on investigational drugs 15 (3), 257-266, 2006 | 77 | 2006 |
| Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control G Semple, A Ren, B Fioravanti, G Pereira, I Calderon, K Choi, Y Xiong, ... Bioorganic & medicinal chemistry letters 21 (10), 3134-3141, 2011 | 75 | 2011 |
| Reversal of a vigilance decrement in the aged rat by subtype-selective nicotinic ligands AJ Grottick, M Haman, R Wyler, GA Higgins Neuropsychopharmacology 28 (5), 880-887, 2003 | 72 | 2003 |
| Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile G Semple, J Lehmann, A Wong, A Ren, M Bruce, YJ Shin, CR Sage, ... Bioorganic & medicinal chemistry letters 22 (4), 1750-1755, 2012 | 59 | 2012 |
Bagnol DidierContineum TherapeuticsVerified email at contineum-tx.com