| TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities R Samarakoon, JM Overstreet, PJ Higgins Cellular signalling 25 (1), 264-268, 2013 | 399 | 2013 |
| PAI‐1: an integrator of cell signaling and migration RP Czekay, CE Wilkins-Port, SP Higgins, J Freytag, JM Overstreet, ... International journal of cell biology 2011 (1), 562481, 2011 | 227 | 2011 |
| TGF-β1→ SMAD/p53/USF2→ PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis R Samarakoon, JM Overstreet, SP Higgins, PJ Higgins Cell and tissue research 347, 117-128, 2012 | 180 | 2012 |
| Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species R Samarakoon, AD Dobberfuhl, C Cooley, JM Overstreet, S Patel, ... Cellular signalling 25 (11), 2198-2209, 2013 | 176 | 2013 |
| Integration of non-SMAD and SMAD signaling in TGF-β1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells R Samarakoon, PJ Higgins Thrombosis and haemostasis 100 (12), 976-983, 2008 | 157 | 2008 |
| TGF-β1/p53 signaling in renal fibrogenesis SP Higgins, Y Tang, CE Higgins, B Mian, W Zhang, RP Czekay, ... Cellular signalling 43, 1-10, 2018 | 143 | 2018 |
| TGF-β1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60c-src/EGFRY845 and Rho/ROCK signaling R Samarakoon, SP Higgins, CE Higgins, PJ Higgins Journal of molecular and cellular cardiology 44 (3), 527-538, 2008 | 129 | 2008 |
| Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity JM Overstreet, R Samarakoon, KK Meldrum, PJ Higgins Cellular signalling 26 (7), 1427-1436, 2014 | 102 | 2014 |
| TGF-β1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling SM Kutz, CE Higgins, R Samarakoon, SP Higgins, RR Allen, L Qi, ... Experimental cell research 312 (7), 1093-1105, 2006 | 88 | 2006 |
| Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype S Anorga, JM Overstreet, LL Falke, J Tang, RG Goldschmeding, ... The FASEB Journal 32 (5), 2644, 2018 | 83 | 2018 |
| Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression R Samarakoon, SS Chitnis, SP Higgins, CE Higgins, JC Krepinsky, ... PloS one 6 (7), e22896, 2011 | 80 | 2011 |
| SERPINE1 (PAI-1) is deposited into keratinocyte migration “trails” and required for optimal monolayer wound repair KM Providence, SP Higgins, A Mullen, A Battista, R Samarakoon, ... Archives of Dermatological Research 300, 303-310, 2008 | 78 | 2008 |
| Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities CC Gifford, J Tang, A Costello, NS Khakoo, TQ Nguyen, ... Clinical science 135 (2), 275-303, 2021 | 77 | 2021 |
| Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3‐and p53‐dependent fibrotic responses R Samarakoon, S Helo, AD Dobberfuhl, NS Khakoo, L Falke, ... The Journal of pathology 236 (4), 421-432, 2015 | 74 | 2015 |
| Plasminogen activator inhibitor type‐1 gene expression and induced migration in TGF‐β1‐stimulated smooth muscle cells is pp60c‐src/MEK‐dependent R Samarakoon, CE Higgins, SP Higgins, SM Kutz, PJ Higgins Journal of cellular physiology 204 (1), 236-246, 2005 | 68 | 2005 |
| The TGF-β1/p53/PAI-1 signaling axis in vascular senescence: Role of caveolin-1 R Samarakoon, SP Higgins, CE Higgins, PJ Higgins Biomolecules 9 (8), 341, 2019 | 67 | 2019 |
| Deregulation of negative controls on TGF-β1 signaling in tumor progression J Tang, CC Gifford, R Samarakoon, PJ Higgins Cancers 10 (6), 159, 2018 | 66 | 2018 |
| Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways S Patel, J Tang, JM Overstreet, S Anorga, F Lian, A Arnouk, ... The FASEB Journal 33 (9), 9797, 2019 | 64 | 2019 |
| Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption R Samarakoon, CE Higgins, SP Higgins, PJ Higgins Cellular Signalling 21 (6), 986-995, 2009 | 60 | 2009 |
| Cancer-associated fibroblasts: mechanisms of tumor progression and novel therapeutic targets RP Czekay, DJ Cheon, R Samarakoon, SM Kutz, PJ Higgins Cancers 14 (5), 1231, 2022 | 58 | 2022 |
Jessica OverstreetEli LillyVerified email at lilly.com
