A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression CA Zarate, JB Singh, PJ Carlson, NE Brutsche, R Ameli, DA Luckenbaugh, ... Archives of general psychiatry 63 (8), 856-864, 2006 | 4035 | 2006 |
The cellular neurobiology of depression HK Manji, WC Drevets, DS Charney Nature medicine 7 (5), 541-547, 2001 | 1581 | 2001 |
Discovering endophenotypes for major depression G Hasler, WC Drevets, HK Manji, DS Charney Neuropsychopharmacology 29 (10), 1765-1781, 2004 | 1456 | 2004 |
New insights into BDNF function in depression and anxiety K Martinowich, H Manji, B Lu Nature neuroscience 10 (9), 1089-1093, 2007 | 1447 | 2007 |
A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression N Diazgranados, L Ibrahim, NE Brutsche, A Newberg, P Kronstein, ... Archives of general psychiatry 67 (8), 793-802, 2010 | 1135 | 2010 |
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders G Sanacora, CA Zarate, JH Krystal, HK Manji Nature reviews Drug discovery 7 (5), 426-437, 2008 | 1083 | 2008 |
Enhancement of hippocampal neurogenesis by lithium G Chen, G Rajkowska, F Du, N Seraji‐Bozorgzad, HK Manji Journal of neurochemistry 75 (4), 1729-1734, 2000 | 774 | 2000 |
The American psychiatric publishing textbook of psychopharmacology AF Schatzberg, CB Nemeroff American Psychiatric Pub, 2009 | 709 | 2009 |
Preclinical models: status of basic research in depression EJ Nestler, E Gould, H Manji Biological psychiatry 52 (6), 503-528, 2002 | 703 | 2002 |
Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression: a randomized clinical trial EJ Daly, JB Singh, M Fedgchin, K Cooper, P Lim, RC Shelton, ME Thase, ... JAMA psychiatry 75 (2), 139-148, 2018 | 678 | 2018 |
Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression HK Manji, JA Quiroz, J Sporn, JL Payne, K Denicoff, NA Gray, ... Biological psychiatry 53 (8), 707-742, 2003 | 651 | 2003 |
The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS G Chen, WZ Zeng, PX Yuan, LD Huang, YM Jiang, ZH Zhao, HK Manji Journal of neurochemistry 72 (2), 879-882, 1999 | 628 | 1999 |
The mood‐stabilizing agent valproate inhibits the activity of glycogen synthase kinase‐3 G Chen, LD Huang, YM Jiang, HK Manji Journal of neurochemistry 72 (3), 1327-1330, 2000 | 621 | 2000 |
The role of the extracellular signal-regulated kinase signaling pathway in mood modulation H Einat, P Yuan, TD Gould, J Li, JH Du, L Zhang, HK Manji, G Chen Journal of Neuroscience 23 (19), 7311-7316, 2003 | 615 | 2003 |
Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment FJ McMahon, S Buervenich, D Charney, R Lipsky, AJ Rush, AF Wilson, ... The American Journal of Human Genetics 78 (5), 804-814, 2006 | 584 | 2006 |
Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention DS Charney, HK Manji Science's STKE 2004 (225), re5-re5, 2004 | 544 | 2004 |
Toward constructing an endophenotype strategy for bipolar disorders G Hasler, WC Drevets, TD Gould, II Gottesman, HK Manji Biological psychiatry 60 (2), 93-105, 2006 | 543 | 2006 |
A double-blind, randomized, placebo-controlled, dose-frequency study of intravenous ketamine in patients with treatment-resistant depression JB Singh, M Fedgchin, EJ Daly, P De Boer, K Cooper, P Lim, C Pinter, ... American Journal of Psychiatry 173 (8), 816-826, 2016 | 537 | 2016 |
Dynamic regulation of mitochondrial function by glucocorticoids J Du, Y Wang, R Hunter, Y Wei, R Blumenthal, C Falke, R Khairova, ... Proceedings of the National Academy of Sciences 106 (9), 3543-3548, 2009 | 529 | 2009 |
Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2’s neurotrophic effects? GJ Moore, JM Bebchuk, K Hasanat, G Chen, N Seraji-Bozorgzad, IB Wilds, ... Biological psychiatry 48 (1), 1-8, 2000 | 503 | 2000 |