| Hypoxia requires notch signaling to maintain the undifferentiated cell state MV Gustafsson, X Zheng, T Pereira, K Gradin, S Jin, J Lundkvist, JL Ruas, ... Developmental cell 9 (5), 617-628, 2005 | 1340 | 2005 |
| Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein K Tanimoto, Y Makino, T Pereira, L Poellinger The EMBO journal, 2000 | 1149 | 2000 |
| Stabilization of HIF-1α is critical to improve wound healing in diabetic mice IR Botusan, VG Sunkari, O Savu, AI Catrina, J Grünler, S Lindberg, ... Proceedings of the National Academy of Sciences 105 (49), 19426-19431, 2008 | 580 | 2008 |
| Hyperglycemia regulates hypoxia-inducible factor-1α protein stability and function SB Catrina, K Okamoto, T Pereira, K Brismar, L Poellinger Diabetes 53 (12), 3226-3232, 2004 | 485 | 2004 |
| Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways X Zheng, S Linke, JM Dias, X Zheng, K Gradin, TP Wallis, BR Hamilton, ... Proceedings of the National Academy of Sciences 105 (9), 3368-3373, 2008 | 308 | 2008 |
| Kynurenic acid and Gpr35 regulate adipose tissue energy homeostasis and inflammation LZ Agudelo, DMS Ferreira, I Cervenka, G Bryzgalova, S Dadvar, ... Cell metabolism 27 (2), 378-392. e5, 2018 | 237 | 2018 |
| Hypoxia inducible factor regulates the cardiac expression and secretion of apelin VP Ronkainen, JJ Ronkainen, SL Hänninen, H Leskinen, JL Ruas, ... The FASEB Journal 21 (8), 1821-1830, 2007 | 237 | 2007 |
| Functional analysis of hypoxia-inducible factor-1α-mediated transactivation: identification of amino acid residues critical for transcriptional activation and/or interaction … JL Ruas, L Poellinger, T Pereira Journal of Biological Chemistry 277 (41), 38723-38730, 2002 | 182 | 2002 |
| Role of CBP in regulating HIF-1-mediated activation of transcription JL Ruas, L Poellinger, T Pereira Journal of cell science 118 (2), 301-311, 2005 | 145 | 2005 |
| Stabilized HIF‐1α is superior to VEGF for angiogenesis in skeletal muscle via adeno‐associated virus gene transfer K Pajusola, J Künnapuu, S Vuorikoski, J Soronen, H André, T Pereira, ... The FASEB journal 19 (10), 1365-1367, 2005 | 144 | 2005 |
| Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP X Zheng, X Wang, Z Ma, V Gupta Sunkari, I Botusan, T Takeda, ... Cell death & disease 3 (6), e322-e322, 2012 | 117 | 2012 |
| Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia M Altun, B Zhao, K Velasco, H Liu, G Hassink, J Paschke, T Pereira, ... Journal of Biological Chemistry 287 (3), 1962-1969, 2012 | 104 | 2012 |
| Complex regulation of the transactivation function of hypoxia-inducible factor-1α by direct interaction with two distinct domains of the CREB-binding protein/p300 JL Ruas, U Berchner-Pfannschmidt, S Malik, K Gradin, J Fandrey, ... Journal of Biological Chemistry 285 (4), 2601-2609, 2010 | 96 | 2010 |
| Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response X Zheng, AX Zhou, P Rouhi, H Uramoto, J Borén, Y Cao, T Pereira, ... Proceedings of the National Academy of Sciences 111 (7), 2560-2565, 2014 | 84 | 2014 |
| Cell-type-specific regulation of degradation of hypoxia-inducible factor 1α: role of subcellular compartmentalization X Zheng, JL Ruas, R Cao, FA Salomons, Y Cao, L Poellinger, T Pereira Molecular and cellular biology, 2006 | 79 | 2006 |
| Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor … T Pereira, X Zheng, JL Ruas, K Tanimoto, L Poellinger Journal of Biological Chemistry 278 (9), 6816-6823, 2003 | 68 | 2003 |
| HIF‐1α and HIF‐2α induce angiogenesis and improve muscle energy recovery H Niemi, K Honkonen, P Korpisalo, J Huusko, E Kansanen, M Merentie, ... European Journal of Clinical Investigation 44 (10), 989-999, 2014 | 56 | 2014 |
| Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development MB Telhada, TM Pereira, MC Lechner Archives of biochemistry and biophysics 298 (2), 715-725, 1992 | 56 | 1992 |
| PI3K-C2α knockdown results in rerouting of insulin signaling and pancreatic beta cell proliferation B Leibiger, T Moede, M Paschen, NO Yunn, JH Lim, SH Ryu, T Pereira, ... Cell Reports 13 (1), 15-22, 2015 | 37 | 2015 |
| HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes POB E Ilegems, G Bryzgalova, J Correia, B Yesildag, E Berra, JL Ruas, TS Pereira Science Translational Medicine 14 (638), 2022 | 36 | 2022 |