G protein-coupled receptors: novel targets for drug discovery in cancer R Lappano, M Maggiolini Nature reviews Drug discovery 10 (1), 47-60, 2011 | 772 | 2011 |
The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17β-estradiol and phytoestrogens in breast cancer cells M Maggiolini, A Vivacqua, G Fasanella, AG Recchia, D Sisci, V Pezzi, ... Journal of Biological Chemistry 279 (26), 27008-27016, 2004 | 563 | 2004 |
G protein–coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17β-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells L Albanito, A Madeo, R Lappano, A Vivacqua, V Rago, A Carpino, ... Cancer research 67 (4), 1859-1866, 2007 | 523 | 2007 |
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17β-estradiol and hydroxytamoxifen in endometrial cancer cells A Vivacqua, D Bonofiglio, AG Recchia, AM Musti, D Picard, S Andò, ... Molecular endocrinology 20 (3), 631-646, 2006 | 460 | 2006 |
Mechanisms of estrogen signaling and gene expression via GPR30 ER Prossnitz, M Maggiolini Molecular and cellular endocrinology 308 (1-2), 32-38, 2009 | 456 | 2009 |
The unfolding stories of GPR30, a new membrane-bound estrogen receptor. M Maggiolini, D Picard The Journal of endocrinology 204 (2), 105-114, 2009 | 455 | 2009 |
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages D Bellizzi, G Rose, P Cavalcante, G Covello, S Dato, F De Rango, ... Genomics 85 (2), 258-263, 2005 | 435 | 2005 |
Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF DP Pandey, R Lappano, L Albanito, A Madeo, M Maggiolini, D Picard The EMBO journal 28 (5), 523-532, 2009 | 397 | 2009 |
17β-Estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the G protein-coupled receptor GPR30 A Vivacqua, D Bonofiglio, L Albanito, A Madeo, V Rago, A Carpino, ... Molecular pharmacology 70 (4), 1414-1423, 2006 | 386 | 2006 |
Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor α in MCF-7 cells S Catalano, L Mauro, S Marsico, C Giordano, P Rizza, V Rago, ... Journal of Biological Chemistry 279 (19), 19908-19915, 2004 | 332 | 2004 |
Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts M Pupo, A Pisano, R Lappano, MF Santolla, EM De Francesco, ... Environmental health perspectives 120 (8), 1177-1182, 2012 | 323 | 2012 |
Estrogen receptor α mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells M Maggiolini, D Bonofiglio, S Marsico, ML Panno, B Cenni, D Picard, ... Molecular pharmacology 60 (3), 595-602, 2001 | 288 | 2001 |
HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs) EM De Francesco, R Lappano, MF Santolla, S Marsico, A Caruso, ... Breast Cancer Research 15, 1-18, 2013 | 260 | 2013 |
Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives M Barton, EJ Filardo, SJ Lolait, P Thomas, M Maggiolini, ER Prossnitz The Journal of steroid biochemistry and molecular biology 176, 4-15, 2018 | 244 | 2018 |
A platform of synthetic lethal gene interaction networks reveals that the GNAQ uveal melanoma oncogene controls the hippo pathway through FAK X Feng, N Arang, DC Rigiracciolo, JS Lee, H Yeerna, Z Wang, S Lubrano, ... Cancer cell 35 (3), 457-472. e5, 2019 | 223 | 2019 |
Oleuropein and hydroxytyrosol inhibit MCF‐7 breast cancer cell proliferation interfering with ERK1/2 activation R Sirianni, A Chimento, A De Luca, I Casaburi, P Rizza, A Onofrio, ... Molecular nutrition & food research 54 (6), 833-840, 2010 | 208 | 2010 |
Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor α M Maggiolini, O Donzé, E Jeannin, S Andò, D Picard Cancer research 59 (19), 4864-4869, 1999 | 208 | 1999 |
Nuclear alternate estrogen receptor GPR30 mediates 17β-estradiol–induced gene expression and migration in breast cancer–associated fibroblasts A Madeo, M Maggiolini Cancer research 70 (14), 6036-6046, 2010 | 202 | 2010 |
The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17β-estradiol on mouse spermatogonial GC-1 cell line R Sirianni, A Chimento, C Ruggiero, A De Luca, R Lappano, S Andò, ... Endocrinology 149 (10), 5043-5051, 2008 | 195 | 2008 |
Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells M Maggiolini, G Statti, A Vivacqua, S Gabriele, V Rago, M Loizzo, ... The Journal of steroid biochemistry and molecular biology 82 (4-5), 315-322, 2002 | 192 | 2002 |