Achieving site-selectivity for C–H activation processes based on distance and geometry: a carpenter’s approach G Meng, NYS Lam, EL Lucas, TG Saint-Denis, P Verma, N Chekshin, ... Journal of the American Chemical Society 142 (24), 10571-10591, 2020 | 276 | 2020 |
Advancing the logic of chemical synthesis: C− H activation as strategic and tactical disconnections for C− C bond construction NYS Lam, K Wu, JQ Yu Angewandte Chemie 133 (29), 15901-15924, 2021 | 252 | 2021 |
A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation T Zhang, YX Luan, NYS Lam, JF Li, Y Li, M Ye, JQ Yu Nature chemistry 13 (12), 1207-1213, 2021 | 76 | 2021 |
Palladium-Catalyzed Enantioselective β-C(sp3)–H Activation Reactions of Aliphatic Acids: A Retrosynthetic Surrogate for Enolate Alkylation and Conjugate Addition EL Lucas, NYS Lam, Z Zhuang, HSS Chan, DA Strassfeld, JQ Yu Accounts of chemical research 55 (4), 537-550, 2022 | 70 | 2022 |
From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents NYS Lam, D Truong, H Burmeister, MV Babak, HU Holtkamp, ... Inorganic chemistry 57 (22), 14427-14434, 2018 | 70 | 2018 |
Molecular editing of aza-arene C–H bonds by distance, geometry and chirality Z Fan, X Chen, K Tanaka, HS Park, NYS Lam, JJ Wong, KN Houk, JQ Yu Nature 610 (7930), 87-93, 2022 | 51 | 2022 |
Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein–Ru (carbene) adduct MP Sullivan, MK Nieuwoudt, GA Bowmaker, NYS Lam, D Truong, ... Chemical communications 54 (48), 6120-6123, 2018 | 44* | 2018 |
Empirical guidelines for the development of remote directing templates through quantitative and experimental analyses NYS Lam, Z Fan, K Wu, HS Park, SY Shim, DA Strassfeld, JQ Yu Journal of the American Chemical Society 144 (6), 2793-2803, 2022 | 40 | 2022 |
Challenges and discoveries in the total synthesis of complex polyketide natural products I Paterson, NYS Lam The Journal of Antibiotics 71 (2), 215-233, 2018 | 39 | 2018 |
An enantioselective Suzuki–Miyaura coupling to form axially chiral biphenols R Pearce-Higgins, LN Hogenhout, PJ Docherty, DM Whalley, ... Journal of the American Chemical Society 144 (33), 15026-15032, 2022 | 28 | 2022 |
A synthesis-enabled relative stereochemical assignment of the C1–C28 region of hemicalide BY Han, NYS Lam, CI MacGregor, JM Goodman, I Paterson Chemical Communications 54 (26), 3247-3250, 2018 | 28 | 2018 |
Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A IE Ndukwe, X Wang, NYS Lam, K Ermanis, KL Alexander, MJ Bertin, ... Chemical Communications 56 (55), 7565-7568, 2020 | 25 | 2020 |
The stereocontrolled total synthesis of polyketide natural products: a thirty-year journey TP Stockdale, NYS Lam, MJ Anketell, I Paterson Bulletin of the Chemical Society of Japan 94 (2), 713-731, 2021 | 23 | 2021 |
A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A NYS Lam, G Muir, VR Challa, R Britton, I Paterson Chemical Communications 55 (65), 9717-9720, 2019 | 23 | 2019 |
Analysis of ruthenium anticancer agents by MEEKC‐UV and MEEKC–ICP‐MS: Impact of structural motifs on lipophilicity and biological activity K Giringer, HU Holtkamp, S Movassaghi, WDJ Tremlett, NYS Lam, ... Electrophoresis 39 (9-10), 1201-1207, 2018 | 18 | 2018 |
Mechanistic Study of Enantioselective Pd-Catalyzed C(sp3)–H Activation of Thioethers Involving Two Distinct Stereomodels TG Saint-Denis, NYS Lam, N Chekshin, PF Richardson, JS Chen, ... ACS catalysis 11 (15), 9738-9753, 2021 | 17 | 2021 |
Quinoline-para-quinones and metals: coordination-assisted formation of quinoline-ortho-quinones M Kubanik, NYS Lam, HU Holtkamp, T Söhnel, RF Anderson, ... Chemical Communications, 2018 | 17 | 2018 |
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents TR Pettigrew, RJ Porter, SJ Walsh, MP Housden, NYS Lam, JS Carroll, ... Chemical Communications 56 (10), 1529-1532, 2020 | 13 | 2020 |
Conquering peaks and illuminating depths: developing stereocontrolled organic reactions to unlock nature's macrolide treasure trove NYS Lam, TP Stockdale, MJ Anketell, I Paterson Chemical Communications 57 (26), 3171-3189, 2021 | 12 | 2021 |
Stereocontrolled synthesis as an enabling tool for the configurational assignment of marine polyketide natural products NYS Lam, I Paterson European Journal of Organic Chemistry 2020 (16), 2310-2320, 2020 | 11 | 2020 |