Articles with public access mandates - Tom Owen-HughesLearn more
Available somewhere: 45
How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?
NJ Schurch, P Schofield, M Gierliński, C Cole, A Sherstnev, V Singh, ...
Rna 22 (6), 839-851, 2016
Mandates: UK Biotechnology and Biological Sciences Research Council, UK Medical …
Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes
GJ Narlikar, R Sundaramoorthy, T Owen-Hughes
Cell 154 (3), 490-503, 2013
Mandates: UK Medical Research Council, Wellcome Trust
Poly (ADP-ribose)–dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1
D Ahel, Z Hořejší, N Wiechens, SE Polo, E Garcia-Wilson, I Ahel, H Flynn, ...
science 325 (5945), 1240-1243, 2009
Mandates: Cancer Research UK
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
W Farnaby, M Koegl, MJ Roy, C Whitworth, E Diers, N Trainor, D Zollman, ...
Nature chemical biology 15 (7), 672-680, 2019
Mandates: Wellcome Trust, European Commission
High-resolution nucleosome mapping reveals transcription-dependent promoter packaging
A Weiner, A Hughes, M Yassour, OJ Rando, N Friedman
Genome research 20 (1), 90-100, 2010
Mandates: US National Institutes of Health
A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization
T Gkikopoulos, P Schofield, V Singh, M Pinskaya, J Mellor, M Smolle, ...
Science 333 (6050), 1758-1760, 2011
Mandates: US National Institutes of Health
Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates
MH Hauer, A Seeber, V Singh, R Thierry, R Sack, A Amitai, ...
Nature structural & molecular biology 24 (2), 99-107, 2017
Mandates: Swiss National Science Foundation, Wellcome Trust, Human Frontier Science …
DNA repair factor APLF is a histone chaperone
PV Mehrotra, D Ahel, DP Ryan, R Weston, N Wiechens, R Kraehenbuehl, ...
Molecular cell 41 (1), 46-55, 2011
Mandates: Cancer Research UK
Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures
H Dürr, A Flaus, T Owen-Hughes, KP Hopfner
Nucleic acids research 34 (15), 4160-4167, 2006
Mandates: German Research Foundation
Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription
V Di Cerbo, F Mohn, DP Ryan, E Montellier, S Kacem, P Tropberger, ...
elife 3, e01632, 2014
Mandates: National Health and Medical Research Council, Australia, German Research …
Mechanisms for ATP‐dependent chromatin remodelling: the means to the end
A Flaus, T Owen‐Hughes
The FEBS journal 278 (19), 3579-3595, 2011
Mandates: Science Foundation Ireland
Phosphorylation of Histone H3 Thr-45 Is Linked to Apoptosis*♦
PJ Hurd, AJ Bannister, K Halls, MA Dawson, M Vermeulen, JV Olsen, ...
Journal of Biological Chemistry 284 (24), 16575-16583, 2009
Mandates: Cancer Research UK
Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment
M Gierliński, C Cole, P Schofield, NJ Schurch, A Sherstnev, V Singh, ...
Bioinformatics 31 (22), 3625-3630, 2015
Mandates: UK Biotechnology and Biological Sciences Research Council, UK Medical …
The chromatin remodelling enzymes SNF2H and SNF2L position nucleosomes adjacent to CTCF and other transcription factors
N Wiechens, V Singh, T Gkikopoulos, P Schofield, S Rocha, ...
PLoS genetics 12 (3), e1005940, 2016
Mandates: UK Biotechnology and Biological Sciences Research Council, Cancer Research …
PICH: a DNA translocase specially adapted for processing anaphase bridge DNA
A Biebricher, S Hirano, JH Enzlin, N Wiechens, WW Streicher, D Huttner, ...
Molecular cell 51 (5), 691-701, 2013
Mandates: Cancer Research UK, Wellcome Trust
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4
AA Watson, P Mahajan, HDT Mertens, MJ Deery, W Zhang, P Pham, X Du, ...
Journal of molecular biology 422 (1), 3-17, 2012
Mandates: Canadian Institutes of Health Research, Genome Canada
Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome
R Sundaramoorthy, AL Hughes, H El-Mkami, DG Norman, H Ferreira, ...
elife 7, e35720, 2018
Mandates: European Molecular Biology Laboratory, Wellcome Trust
MacroH2A allows ATP-dependent chromatin remodeling by SWI/SNF and ACF complexes but specifically reduces recruitment of SWI/SNF
EY Chang, H Ferreira, J Somers, DA Nusinow, T Owen-Hughes, ...
Biochemistry 47 (51), 13726-13732, 2008
Mandates: Swiss National Science Foundation, US National Institutes of Health
CENP-A confers a reduction in height on octameric nucleosomes
MDD Miell, CJ Fuller, A Guse, HM Barysz, A Downes, T Owen-Hughes, ...
Nature structural & molecular biology 20 (6), 763-765, 2013
Mandates: US National Institutes of Health, German Research Foundation, Wellcome Trust
The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4
T Gkikopoulos, V Singh, K Tsui, S Awad, MJ Renshaw, P Scholfield, ...
The EMBO journal 30 (10), 1919-1927, 2011
Mandates: Swiss National Science Foundation, Canadian Institutes of Health Research
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