| Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development U Marx, T Akabane, TB Andersson, E Baker, M Beilmann, S Beken, ... Altex 37 (3), 365, 2020 | 238 | 2020 |
| A lung/liver-on-a-chip platform for acute and chronic toxicity studies D Bovard, A Sandoz, K Luettich, S Frentzel, A Iskandar, D Marescotti, ... Lab on a Chip 18 (24), 3814-3829, 2018 | 155 | 2018 |
| Transcription factor YY1 expression in human gastrointestinal cancer cells D Chinnappan, D Xiao, A Ratnasari, C Andry, TC King, HC Weber International journal of oncology 34 (5), 1417-1423, 2009 | 120 | 2009 |
| A framework for in vitro systems toxicology assessment of e-liquids AR Iskandar, I Gonzalez-Suarez, S Majeed, D Marescotti, A Sewer, ... Toxicology Mechanisms and Methods 26 (6), 392-416, 2016 | 93 | 2016 |
| Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity AJ Clippinger, D Allen, H Behrsing, KA BéruBé, MB Bolger, W Casey, ... Toxicology in Vitro 52, 131-145, 2018 | 82 | 2018 |
| Case study: the role of mechanistic network models in systems toxicology J Hoeng, M Talikka, F Martin, A Sewer, X Yang, A Iskandar, WK Schlage, ... Drug Discovery Today 19 (2), 183-192, 2014 | 78 | 2014 |
| β-Cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice AR Iskandar, C Liu, DE Smith, KQ Hu, SW Choi, LM Ausman, XD Wang Cancer Prevention Research 6 (4), 309-320, 2013 | 71 | 2013 |
| 3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product AR Iskandar, C Mathis, F Martin, P Leroy, A Sewer, S Majeed, D Kuehn, ... ALTEX-Alternatives to animal experimentation 34 (1), 23-48, 2017 | 69 | 2017 |
| A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human … AR Iskandar, C Mathis, WK Schlage, S Frentzel, P Leroy, Y Xiang, ... Toxicology in vitro 39, 29-51, 2017 | 65 | 2017 |
| Impact assessment of cigarette smoke exposure on organotypic bronchial epithelial tissue cultures: a comparison of mono-culture and coculture model containing fibroblasts AR Iskandar, Y Xiang, S Frentzel, M Talikka, P Leroy, D Kuehn, E Guedj, ... Toxicological Sciences 147 (1), 207-221, 2015 | 62 | 2015 |
| Systems toxicology assessment of the biological impact of a candidate modified risk tobacco product on human organotypic oral epithelial cultures F Zanetti, A Sewer, C Mathis, AR Iskandar, R Kostadinova, WK Schlage, ... Chemical research in toxicology 29 (8), 1252-1269, 2016 | 61 | 2016 |
| In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue … WK Schlage, AR Iskandar, R Kostadinova, Y Xiang, A Sewer, S Majeed, ... Toxicology mechanisms and methods 24 (7), 470-487, 2014 | 61 | 2014 |
| Systems approaches evaluating the perturbation of xenobiotic metabolism in response to cigarette smoke exposure in nasal and bronchial tissues AR Iskandar, F Martin, M Talikka, WK Schlage, R Kostadinova, C Mathis, ... BioMed research international 2013 (1), 512086, 2013 | 61 | 2013 |
| β-Cryptoxanthin reduced lung tumor multiplicity and inhibited lung cancer cell motility by downregulating nicotinic acetylcholine receptor α7 signaling AR Iskandar, B Miao, X Li, KQ Hu, C Liu, XD Wang Cancer Prevention Research 9 (11), 875-886, 2016 | 52 | 2016 |
| Organs-on-a-chip: A new paradigm for toxicological assessment and preclinical drug development D Bovard, A Iskandar, K Luettich, J Hoeng, MC Peitsch Toxicology Research and Application 1, 2397847317726351, 2017 | 51 | 2017 |
| Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology B Phillips, M Esposito, J Verbeeck, S Boué, A Iskandar, G Vuillaume, ... Inhalation toxicology 27 (9), 405-431, 2015 | 46 | 2015 |
| Impact assessment of repeated exposure of organotypic 3D bronchial and nasal tissue culture models to whole cigarette smoke D Kuehn, S Majeed, E Guedj, R Dulize, K Baumer, A Iskandar, S Boue, ... JoVE (Journal of Visualized Experiments), e52325, 2015 | 46 | 2015 |
| Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette … AR Iskandar, B Titz, A Sewer, P Leroy, T Schneider, F Zanetti, C Mathis, ... Toxicology Research 6 (5), 631-653, 2017 | 36 | 2017 |
| Construction of biological networks from unstructured information based on a semi-automated curation workflow J Szostak, S Ansari, S Madan, J Fluck, M Talikka, A Iskandar, H De Leon, ... Database 2015, bav057, 2015 | 35 | 2015 |
| Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e … AR Iskandar, F Zanetti, D Marescotti, B Titz, A Sewer, A Kondylis, P Leroy, ... Archives of Toxicology 93 (11), 3229-3247, 2019 | 34 | 2019 |