| Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’ AM Levin, DL Bates, AM Ring, C Krieg, JT Lin, L Su, I Moraga, ME Raeber, ... Nature 484 (7395), 529-533, 2012 | 562 | 2012 |
| Structural linkage between ligand discrimination and receptor activation by type I interferons C Thomas, I Moraga, D Levin, PO Krutzik, Y Podoplelova, A Trejo, C Lee, ... Cell 146 (4), 621-632, 2011 | 391 | 2011 |
| Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15 AM Ring, JX Lin, D Feng, S Mitra, M Rickert, GR Bowman, VS Pande, P Li, ... Nature immunology 13 (12), 1187-1195, 2012 | 292 | 2012 |
| Insights into cytokine–receptor interactions from cytokine engineering JB Spangler, I Moraga, JL Mendoza, KC Garcia Annual review of immunology 33 (1), 139-167, 2015 | 273 | 2015 |
| Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands I Moraga, G Wernig, S Wilmes, V Gryshkova, CP Richter, WJ Hong, ... Cell 160 (6), 1196-1208, 2015 | 165 | 2015 |
| Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations S Wilmes, M Hafer, J Vuorio, JA Tucker, H Winkelmann, S Löchte, ... Science 367 (6478), 643-652, 2020 | 143 | 2020 |
| Receptor density is key to the alpha2/beta interferon differential activities I Moraga, D Harari, G Schreiber, G Uzé, S Pellegrini Molecular and cellular biology 29 (17), 4778-4787, 2009 | 121 | 2009 |
| Functional selectivity in cytokine signaling revealed through a pathogenic EPO mutation AR Kim, JC Ulirsch, S Wilmes, E Unal, I Moraga, M Karakukcu, D Yuan, ... Cell 168 (6), 1053-1064. e15, 2017 | 118 | 2017 |
| The IFN-λ-IFN-λR1-IL-10Rβ complex reveals structural features underlying type III IFN functional plasticity JL Mendoza, WM Schneider, HH Hoffmann, K Vercauteren, KM Jude, ... Immunity 46 (3), 379-392, 2017 | 110 | 2017 |
| Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines IS Junttila, RJ Creusot, I Moraga, DL Bates, MT Wong, MN Alonso, ... Nature chemical biology 8 (12), 990-998, 2012 | 87 | 2012 |
| Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers I Moraga, JB Spangler, JL Mendoza, M Gakovic, TS Wehrman, P Krutzik, ... Elife 6, e22882, 2017 | 78 | 2017 |
| The role of RPGR in cilia formation and actin stability M Gakovic, X Shu, I Kasioulis, S Carpanini, I Moraga, AF Wright Human molecular genetics 20 (24), 4840-4850, 2011 | 73 | 2011 |
| Multifarious determinants of cytokine receptor signaling specificity I Moraga, J Spangler, JL Mendoza, KC Garcia Advances in immunology 121, 1-39, 2014 | 72 | 2014 |
| Decoupling the functional pleiotropy of stem cell factor by tuning c-Kit signaling CCM Ho, A Chhabra, P Starkl, PJ Schnorr, S Wilmes, I Moraga, HS Kwon, ... Cell 168 (6), 1041-1052. e18, 2017 | 71 | 2017 |
| Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency I Moraga, D Richter, S Wilmes, H Winkelmann, K Jude, C Thomas, ... Science signaling 8 (402), ra114-ra114, 2015 | 59 | 2015 |
| Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses C Gorby, J Sotolongo Bellón, S Wilmes, W Warda, E Pohler, PK Fyfe, ... Science signaling 13 (649), eabc0653, 2020 | 58 | 2020 |
| Role of the diacylglycerol kinase α-conserved domains in membrane targeting in intact T cells E Merino, MA Sanjuán, I Moraga, A Ciprés, I Mérida Journal of Biological Chemistry 282 (48), 35396-35404, 2007 | 43 | 2007 |
| Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments D Richter, I Moraga, H Winkelmann, O Birkholz, S Wilmes, M Schulte, ... Nature communications 8 (1), 15976, 2017 | 39 | 2017 |
| IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein S Gaggero, J Martinez-Fabregas, A Cozzani, PK Fyfe, M Leprohon, ... Science immunology 7 (78), eade5686, 2022 | 38 | 2022 |
| Kinetics of cytokine receptor trafficking determine signaling and functional selectivity J Martinez-Fabregas, S Wilmes, L Wang, M Hafer, E Pohler, J Lokau, ... Elife 8, e49314, 2019 | 36 | 2019 |
