Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase A Rak, O Pylypenko, T Durek, A Watzke, S Kushnir, L Brunsveld, ... Science 302 (5645), 646-650, 2003 | 258 | 2003 |
Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase KS Harris, T Durek, Q Kaas, AG Poth, EK Gilding, BF Conlan, I Saska, ... Nature communications 6 (1), 10199, 2015 | 246 | 2015 |
Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme T Durek, VY Torbeev, SBH Kent Proceedings of the National Academy of Sciences 104 (12), 4846-4851, 2007 | 181 | 2007 |
Structure of doubly prenylated Ypt1: GDI complex and the mechanism of GDI‐mediated Rab recycling O Pylypenko, A Rak, T Durek, S Kushnir, BE Dursina, NH Thomae, ... The EMBO journal 25 (1), 13-23, 2006 | 149 | 2006 |
Disulfide-rich macrocyclic peptides as templates in drug design SE Northfield, CK Wang, CI Schroeder, T Durek, MW Kan, JE Swedberg, ... European Journal of Medicinal Chemistry 77, 248-257, 2014 | 144 | 2014 |
Fmoc-based synthesis of disulfide-rich cyclic peptides O Cheneval, CI Schroeder, T Durek, P Walsh, YH Huang, S Liras, ... The Journal of organic chemistry 79 (12), 5538-5544, 2014 | 132 | 2014 |
Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases MA Jackson, EK Gilding, T Shafee, KS Harris, Q Kaas, S Poon, K Yap, ... Nature Communications 9 (1), 2411, 2018 | 129 | 2018 |
Preformed selenoesters enable rapid native chemical ligation at intractable sites T Durek, PF Alewood Angewandte Chemie International Edition 50 (50), 12042-12045, 2011 | 127 | 2011 |
Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain JR Deuis, JS Wingerd, Z Winter, T Durek, Z Dekan, SR Sousa, ... Toxins 8 (3), 78, 2016 | 115 | 2016 |
Protein semi-synthesis: new proteins for functional and structural studies T Durek, CFW Becker Biomolecular engineering 22 (5-6), 153-172, 2005 | 84 | 2005 |
Site-specific sequential protein labeling catalyzed by a single recombinant ligase FBH Rehm, TJ Harmand, K Yap, T Durek, DJ Craik, HL Ploegh Journal of the American Chemical Society 141 (43), 17388-17393, 2019 | 80 | 2019 |
Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin‐2 CI Schroeder, LD Rash, X Vila‐Farrés, KJ Rosengren, M Mobli, GF King, ... Angewandte Chemie International Edition 53 (4), 1017-1020, 2014 | 80 | 2014 |
Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells I Vetter, CA Mozar, T Durek, JS Wingerd, PF Alewood, MJ Christie, ... Biochemical pharmacology 83 (11), 1562-1571, 2012 | 80 | 2012 |
Synthesis of fluorescently labeled mono-and diprenylated Rab7 GTPase T Durek, K Alexandrov, RS Goody, A Hildebrand, I Heinemann, ... Journal of the American Chemical Society 126 (50), 16368-16378, 2004 | 78 | 2004 |
Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro K Alexandrov, I Heinemann, T Durek, V Sidorovitch, RS Goody, ... Journal of the American Chemical Society 124 (20), 5648-5649, 2002 | 78 | 2002 |
A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors J Du, K Yap, LY Chan, FBH Rehm, FY Looi, AG Poth, EK Gilding, Q Kaas, ... Nature Communications 11 (1), 1575, 2020 | 73 | 2020 |
Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization AC Conibear, S Chaousis, T Durek, K Johan Rosengren, DJ Craik, ... Peptide Science 106 (1), 89-100, 2016 | 64 | 2016 |
Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization FBH Rehm, MA Jackson, E De Geyter, K Yap, EK Gilding, T Durek, ... Proceedings of the National Academy of Sciences 116 (16), 7831-7836, 2019 | 59 | 2019 |
Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1 T Durek, I Vetter, CIA Wang, L Motin, O Knapp, DJ Adams, RJ Lewis, ... ACS chemical biology 8 (6), 1215-1222, 2013 | 59 | 2013 |
A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein KS Harris, RF Guarino, RS Dissanayake, P Quimbar, OC McCorkelle, ... Scientific reports 9 (1), 10820, 2019 | 57 | 2019 |