| Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications D Nathan, K Ingvarsdottir, DE Sterner, GR Bylebyl, M Dokmanovic, ... Genes & development 20 (8), 966-976, 2006 | 482 | 2006 |
| H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex A Wyce, T Xiao, KA Whelan, C Kosman, W Walter, D Eick, TR Hughes, ... Molecular cell 27 (2), 275-288, 2007 | 254 | 2007 |
| Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma M Natsuizaka, KA Whelan, S Kagawa, K Tanaka, V Giroux, ... Nature communications 8 (1), 1758, 2017 | 197 | 2017 |
| Clinical and translational advances in esophageal squamous cell carcinoma ZW Reichenbach, MG Murray, R Saxena, D Farkas, EG Karassik, ... Advances in cancer research 144, 95-135, 2019 | 156 | 2019 |
| In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation MK Tallent, N Varghis, Y Skorobogatko, L Hernandez-Cuebas, K Whelan, ... Journal of Biological Chemistry 284 (1), 174-181, 2009 | 152 | 2009 |
| Three-dimensional organoids reveal therapy resistance of esophageal and oropharyngeal squamous cell carcinoma cells T Kijima, H Nakagawa, M Shimonosono, PM Chandramouleeswaran, ... Cellular and molecular gastroenterology and hepatology 7 (1), 73-91, 2019 | 138 | 2019 |
| Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1 J Huang, JR Kent, B Placek, KA Whelan, CM Hollow, PY Zeng, NW Fraser, ... Journal of virology 80 (12), 5740-5746, 2006 | 134 | 2006 |
| ErbB2 requires integrin α5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells KK Haenssen, SA Caldwell, KS Shahriari, SRE Jackson, KA Whelan, ... Journal of cell science 123 (8), 1373-1382, 2010 | 126 | 2010 |
| The esophageal organoid system reveals functional interplay between notch and cytokines in reactive epithelial changes Y Kasagi, PM Chandramouleeswaran, KA Whelan, K Tanaka, V Giroux, ... Cellular and molecular gastroenterology and hepatology 5 (3), 333-352, 2018 | 108 | 2018 |
| Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration V Giroux, AA Lento, M Islam, JR Pitarresi, A Kharbanda, KE Hamilton, ... The Journal of clinical investigation 127 (6), 2378-2391, 2017 | 106 | 2017 |
| Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming S Srinivasan, M Guha, DW Dong, KA Whelan, G Ruthel, Y Uchikado, ... Oncogene 35 (12), 1585-1595, 2016 | 101 | 2016 |
| IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment M Natsuizaka, H Kinugasa, S Kagawa, KA Whelan, S Naganuma, ... American journal of cancer research 4 (1), 29, 2014 | 91 | 2014 |
| Fibroblast growth factor-2–mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma O Maehara, G Suda, M Natsuizaka, S Ohnishi, Y Komatsu, F Sato, ... Carcinogenesis 38 (11), 1073-1083, 2017 | 87 | 2017 |
| Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance KA Whelan, PM Chandramouleeswaran, K Tanaka, M Natsuizaka, ... Oncogene 36 (34), 4843-4858, 2017 | 87 | 2017 |
| Mitochondrial SOD2 regulates epithelial–mesenchymal transition and cell populations defined by differential CD44 expression H Kinugasa, KA Whelan, K Tanaka, M Natsuizaka, A Long, A Guo, ... Oncogene 34 (41), 5229-5239, 2015 | 86 | 2015 |
| The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance KA Whelan, LP Schwab, SV Karakashev, L Franchetti, GJ Johannes, ... Journal of Biological Chemistry 288 (22), 15865-15877, 2013 | 84 | 2013 |
| Generation and characterization of patient‐derived head and neck, oral, and esophageal cancer organoids TA Karakasheva, T Kijima, M Shimonosono, H Maekawa, V Sahu, ... Current Protocols in Stem Cell Biology 53 (1), e109, 2020 | 79 | 2020 |
| Hypoxia suppression of Bim and Bmf blocks anoikis and luminal clearing during mammary morphogenesis KA Whelan, SA Caldwell, KS Shahriari, SRE Jackson, LD Franchetti, ... Molecular biology of the cell 21 (22), 3829-3837, 2010 | 78 | 2010 |
| WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma A Long, V Giroux, KA Whelan, KE Hamilton, MP Tétreault, K Tanaka, ... Carcinogenesis 36 (5), 598-606, 2015 | 75 | 2015 |
| Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities S Kagawa, M Natsuizaka, KA Whelan, N Facompre, S Naganuma, ... Oncogene 34 (18), 2347-2359, 2015 | 72 | 2015 |