Circular ecDNA promotes accessible chromatin and high oncogene expression S Wu, KM Turner, N Nguyen, R Raviram, M Erb, J Santini, J Luebeck, ... Nature 575 (7784), 699-703, 2019 | 434 | 2019 |
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers H Kim, NP Nguyen, K Turner, S Wu, AD Gujar, J Luebeck, J Liu, ... Nature genetics 52 (9), 891-897, 2020 | 343 | 2020 |
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling S Chowdhry, C Zanca, U Rajkumar, T Koga, Y Diao, R Raviram, F Liu, ... Nature 569 (7757), 570-575, 2019 | 196 | 2019 |
ecDNA hubs drive cooperative intermolecular oncogene expression KL Hung, KE Yost, L Xie, Q Shi, K Helmsauer, J Luebeck, R Schöpflin, ... Nature 600 (7890), 731-736, 2021 | 182 | 2021 |
The evolutionary dynamics of extrachromosomal DNA in human cancers JT Lange, JC Rose, CY Chen, Y Pichugin, L Xie, J Tang, KL Hung, ... Nature genetics 54 (10), 1527-1533, 2022 | 79 | 2022 |
AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications J Luebeck, C Coruh, SR Dehkordi, JT Lange, KM Turner, V Deshpande, ... Nature communications 11 (1), 4374, 2020 | 72 | 2020 |
EcSeg: semantic segmentation of metaphase images containing extrachromosomal DNA U Rajkumar, K Turner, J Luebeck, V Deshpande, M Chandraker, ... Iscience 21, 428-435, 2019 | 39 | 2019 |
Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers JT Lange, CY Chen, Y Pichugin, L Xie, J Tang, KL Hung, KE Yost, Q Shi, ... BioRxiv, 2021.06. 11.447968, 2021 | 17 | 2021 |
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma OS Chapman, J Luebeck, S Sridhar, ITL Wong, D Dixit, S Wang, G Prasad, ... Nature genetics 55 (12), 2189-2199, 2023 | 7 | 2023 |
DeepViFi: detecting oncoviral infections in cancer genomes using transformers U Rajkumar, S Javadzadeh, M Bafna, D Wu, R Yu, J Shang, V Bafna Proceedings of the 13th ACM International Conference on Bioinformatics …, 2022 | 5 | 2022 |
Fastvifi: fast and accurate detection of (hybrid) viral DNA and RNA S Javadzadeh, U Rajkumar, N Nguyen, S Sarmashghi, J Luebeck, ... NAR Genomics and Bioinformatics 4 (2), lqac032, 2022 | 3 | 2022 |
A CNN-based cell tracking method for multi-slice intravital imaging data K Fujimoto, T Mizugaki, U Rajkumar, H Shigeta, S Seno, Y Uchida, M Ishii, ... Proceedings of the 12th ACM Conference on Bioinformatics, Computational …, 2021 | 2 | 2021 |
Permutations resilient to deletions N Alon, S Butler, R Graham, UC Rajkumar Annals of Combinatorics 22, 673-680, 2018 | 2 | 2018 |
Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change SR Dehkordi, ITL Wong, J Ni, J Luebeck, K Zhu, G Prasad, ... bioRxiv, 2023 | | 2023 |
Deep Learning in Cancer Biology U Rajkumar University of California, San Diego, 2022 | | 2022 |
Methods of treating extrachromosomal dna expressing cancers P Mischel, V Bafna, J Ko, W Zhang, U Rajkumar | | 2019 |